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Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei243ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLOT266835:G1G20-519-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Ordered Locus Names:mlr0628
OrganismiMesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001196311 – 474Glutamate--tRNA ligase 1Add BLAST474

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi266835.mlr0628

Structurei

3D structure databases

ProteinModelPortaliQ98MD0
SMRiQ98MD0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 21"HIGH" regionUniRule annotationAdd BLAST11
Motifi240 – 244"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q98MD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKVVTRFA PSPTGYLHIG GARTALFNWL YAKHTGGTML LRIEDTDRER
60 70 80 90 100
STAAATAAIL DGLSWLGLGW DGDAVSQFER APRHREVAEE LVRMGKAYYS
110 120 130 140 150
YETPAELEAM REAARAKGLP PRYNGQWRDR TPSEAPAGVK GAIRIKAPTE
160 170 180 190 200
GETIVHDRVQ GEVRFPNKDL DDFIILRSDG NPTYMHAVVV DDHDMGVTHI
210 220 230 240 250
IRGDDHLTNA ARQTVIYNAM GWDVPSMSHI PLIHGADGAK LSKRHGALGV
260 270 280 290 300
EAYRAMGYLP EALLNYLARL GWSHGDDEIM SIKDMISWFD IGDVNKGAAR
310 320 330 340 350
FDFAKLEAIN GAHMRRMADA QLLDIFIATL PYLEGGPAMA ARLNEHNKAQ
360 370 380 390 400
LLAALPGLKE RAKTLVELVD GAAFLFATRP LPVDEKAALL LNDGARKILR
410 420 430 440 450
GAHEALNALS GDWTAAAAEA AVRDYALAGG HKLGAVAQPL RAALTGKSTS
460 470
PGVFDVLAVL GREESLARIA DQID
Length:474
Mass (Da):51,492
Last modified:October 1, 2001 - v1
Checksum:i7A2F5D16AFF4DAFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB48183.1
RefSeqiWP_010909538.1, NC_002678.2

Genome annotation databases

EnsemblBacteriaiBAB48183; BAB48183; BAB48183
KEGGimlo:mlr0628
PATRICifig|266835.9.peg.505

Similar proteinsi

Entry informationi

Entry nameiSYE1_RHILO
AccessioniPrimary (citable) accession number: Q98MD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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