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Protein

Glycerol kinase

Gene

glpK

Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.UniRule annotation

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotation

Enzyme regulationi

Inhibited by fructose 1,6-bisphosphate (FBP).UniRule annotation

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Glycerol kinase (glpK)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol, the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei12SubstrateUniRule annotation1
Binding sitei16ATPUniRule annotation1
Binding sitei134SubstrateUniRule annotation1
Binding sitei265ATPUniRule annotation1
Binding sitei308ATP; via carbonyl oxygenUniRule annotation1
Binding sitei312ATP; via amide nitrogenUniRule annotation1
Binding sitei327ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 14ATPUniRule annotation3
Nucleotide bindingi411 – 415ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycerol metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLOT266835:G1G20-578-MONOMER
UniPathwayiUPA00618; UER00672

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinaseUniRule annotation (EC:2.7.1.30UniRule annotation)
Alternative name(s):
ATP:glycerol 3-phosphotransferaseUniRule annotation
GlycerokinaseUniRule annotation
Short name:
GKUniRule annotation
Gene namesi
Name:glpKUniRule annotation
Ordered Locus Names:mll0700
OrganismiMesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000594821 – 496Glycerol kinaseAdd BLAST496

Interactioni

Protein-protein interaction databases

STRINGi266835.mll0700

Structurei

3D structure databases

ProteinModelPortaliQ98M73
SMRiQ98M73
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni82 – 83Substrate bindingUniRule annotation2
Regioni243 – 244Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the FGGY kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QVN Bacteria
COG0554 LUCA
HOGENOMiHOG000222134
KOiK00864
OMAiWQDTRTQ
OrthoDBiPOG091H02FA

Family and domain databases

HAMAPiMF_00186 Glycerol_kin, 1 hit
InterProiView protein in InterPro
IPR000577 Carb_kinase_FGGY
IPR018485 Carb_kinase_FGGY_C
IPR018483 Carb_kinase_FGGY_CS
IPR018484 Carb_kinase_FGGY_N
IPR005999 Glycerol_kin
PfamiView protein in Pfam
PF02782 FGGY_C, 1 hit
PF00370 FGGY_N, 1 hit
PIRSFiPIRSF000538 GlpK, 1 hit
TIGRFAMsiTIGR01311 glycerol_kin, 1 hit
PROSITEiView protein in PROSITE
PS00445 FGGY_KINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q98M73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGFVLAIDQ GTTSTRAILF DGQMKVAGSG QKEFAQHYPA SGWVEHDPEE
60 70 80 90 100
IWASVVTTVK AALKNAGKAA SDVAAIGITN QRETVVVWDR ATGKPIHNAI
110 120 130 140 150
VWQDRRTAPL CQKLKKQGLE KKFTRKTGLL LDPYFSGTKI AWILDKVKGG
160 170 180 190 200
RKRAEKGELL AGTIDSFLIW RLTGGKVHAT DATNASRTLV YNIAENAWDD
210 220 230 240 250
ELLAILNIPA KLLPQVKDCA DDYGVTERDL FGAEIRILGV AGDQHAATIG
260 270 280 290 300
QACFEPGMMK STYGTGCFAL LNTGSDLVRS KNRLLTTIAY RLNGKTTYAL
310 320 330 340 350
EGSIFIAGAA VQWLRDGIKV IGKAEQSGKL ADEADPTQNV YLVPAFVGLG
360 370 380 390 400
APHWDAEARG AIFGLTRNSG PAEFARAALE AVAYQTRDLL DAMRKDWKGT
410 420 430 440 450
SAKTVLRVDG GMVASDWTMQ RLADILDAPV DRPTILETTA LGAAWLAGSK
460 470 480 490
AGVWPKAKEF AKSWALERRF KPEMDIATRS AKLAGWRDAV RRTLSA
Length:496
Mass (Da):53,804
Last modified:October 1, 2001 - v1
Checksum:i2A360DECD38EE8A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB48240.1
RefSeqiWP_010909595.1, NC_002678.2

Genome annotation databases

EnsemblBacteriaiBAB48240; BAB48240; BAB48240
KEGGimlo:mll0700
PATRICifig|266835.9.peg.564

Similar proteinsi

Entry informationi

Entry nameiGLPK_RHILO
AccessioniPrimary (citable) accession number: Q98M73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health