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Protein

Glutamate--tRNA ligase 2

Gene

gltX2

Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei253ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLOT266835:G1G20-661-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 2UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 2UniRule annotation
Short name:
GluRS 2UniRule annotation
Gene namesi
Name:gltX2UniRule annotation
Ordered Locus Names:mll0813
OrganismiMesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001196321 – 457Glutamate--tRNA ligase 2Add BLAST457

Proteomic databases

PRIDEiQ98LZ1

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi266835.mll0813

Structurei

3D structure databases

ProteinModelPortaliQ98LZ1
SMRiQ98LZ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi9 – 19"HIGH" regionUniRule annotationAdd BLAST11
Motifi250 – 254"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252721
KOiK01885
OMAiLYPCYET
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q98LZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVTVRFAPS PTGRIHIGNA RTALFNWLFA LNNKGRFIQR FDDTDIGRSK
60 70 80 90 100
QEFADAILYD LHWLGIFPDA TEYQSRRFEV YDAAVERLKA AGVLYACYET
110 120 130 140 150
PEELDLRRKV RRTRGLPPVY GREALALTHE QVAEYQADGR RPHWRFLLPN
160 170 180 190 200
FTGDPLQPER TEVHWKDLVR GEETVDLASL SDPVLVREDG TYLYTLPSVV
210 220 230 240 250
DDIEMGVSHV IRGDDHVTNT GVQIALFKAL GTEPPVFGHH NLLTTVSGEG
260 270 280 290 300
LSKRTGALSI ESLREDGIEP MAVASLAVLV GTSENVAAAH DLTELAGHFD
310 320 330 340 350
PAATSKSSAK FDPDELFVLN RVLMHHMPFD EARDRLMVLG ISGEQAEPFW
360 370 380 390 400
LAVRGNLDRL ADAVGWWRIL REGPQDRPEF SDDDRDFLGQ AFEVLPEEPW
410 420 430 440 450
NGTVWKDWTG KIREATGRKG KGLFMPLRLA LTGLPSGPEL ADLLPLMGRE

GTLARRP
Length:457
Mass (Da):51,184
Last modified:October 1, 2001 - v1
Checksum:iE5769DEBD8748BF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB48322.1
RefSeqiWP_010909677.1, NC_002678.2

Genome annotation databases

EnsemblBacteriaiBAB48322; BAB48322; BAB48322
KEGGimlo:mll0813
PATRICifig|266835.9.peg.647

Similar proteinsi

Entry informationi

Entry nameiSYE2_RHILO
AccessioniPrimary (citable) accession number: Q98LZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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