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Q98LT6 (GCSP_RHILO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:mlr0885
OrganismRhizobium loti (strain MAFF303099) (Mesorhizobium loti) [Complete proteome] [HAMAP]
Taxonomic identifier266835 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium

Protein attributes

Sequence length937 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 937937Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000166931

Amino acid modifications

Modified residue6861N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q98LT6 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: D135C7B4C9DD0471

FASTA93799,386
        10         20         30         40         50         60 
MMTTALTPFS ARHIGPGVND VRAMLAVIGV PSVETLISQA VPQSIRLDLP LTLPAPASEA 

        70         80         90        100        110        120 
EALAELSAIM AKNTVLKSFI GAGYHGVHVP PVIQRNLFEN PAWYTAYTPY QAEISQGRLE 

       130        140        150        160        170        180 
MLFNFQTLVT ELTGLPVASA SLLDEATAVA EAVGIALRHH RDKRTKVAFA GTPHPQTLDV 

       190        200        210        220        230        240 
VRTRAEPLGI EIDGETIDDN TAALLVSWPD TLGVYGDHKA AIDKARAAGA LVVFIADPLG 

       250        260        270        280        290        300 
LTLTDAPAKL GADIAVGPMQ RFGVPMGFGG PHAAYCAVSD RLTRLMPGRL VGQSTDSKGR 

       310        320        330        340        350        360 
PGYRLALQTR EQHIRRDKAT SNICTAQALL ANMATAYAIW HGPAGLQAIA GRIHALANRL 

       370        380        390        400        410        420 
ASGLKAAGVS VLGASRFDTV TVEAKGKAAE IAEAAEKTGR LLRVLDADHV GIAFDETSTD 

       430        440        450        460        470        480 
ADLDAIASLF GAKAAPSADS TVPGKPRGKE FLTQPVFNEN KSETDMMRLL RRLADKDLAL 

       490        500        510        520        530        540 
DRSMIPLGSC TMKLNAAAEM MPVSWPSIAD LHPFAPASHS AGYRAMIGEL EGWLSEITGF 

       550        560        570        580        590        600 
DAVSLQPNAG SQGEYAGLLA IRAYHRSRGE GHRTVCLIPS SAHGTNPASA AMAGMSVVVV 

       610        620        630        640        650        660 
RCLEDGNIDM DDMRAKANEH SKNLAALMFT YPSTHGVYEE GARHLCALIH EHGGQVYFDG 

       670        680        690        700        710        720 
ANLNALVALA RPADIGADVC HMNLHKTFCI PHGGGGPGVG PIGVKAHLKP YLPGHVTEGS 

       730        740        750        760        770        780 
AHAVSAAPFG SASILPITWM YIRMMGAAGL KQATETAIIS ANYVATRLAP HFPLLYKGRH 

       790        800        810        820        830        840 
DRIAHECILD TRVLKESAGI SVDDIAKRLI DYGFHAPTMS FPVAGTLMVE PTESEPKREL 

       850        860        870        880        890        900 
DRFCEAMIAI AGEAAKVARG DWPLADNPLV NAPHTAAETL AGQWTHPYSR LEAAYPAGDA 

       910        920        930 
DTAAKYWPPV SRIDNVAGDR NLVCSCPPLS DYLGAAE 

« Hide

References

[1]"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti."
Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. expand/collapse author list , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S.
DNA Res. 7:331-338(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MAFF303099.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000012 Genomic DNA. Translation: BAB48377.1.
RefSeqNP_102591.1. NC_002678.2.

3D structure databases

ProteinModelPortalQ98LT6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266835.mlr0885.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB48377; BAB48377; BAB48377.
GeneID1225254.
KEGGmlo:mlr0885.
PATRIC22475570. VBIMesLot2464_0704.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAIRVQVII.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycMLOT266835:GJ9L-704-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_RHILO
AccessionPrimary (citable) accession number: Q98LT6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: October 1, 2001
Last modified: February 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families