Q98LT6 (GCSP_RHILO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycine dehydrogenase [decarboxylating]
EC=1.4.4.2

Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase

Gene names

Name:	gcvP
Ordered Locus Names:	mlr0885

Organism

Rhizobium loti (strain MAFF303099) (Mesorhizobium loti) [Complete proteome] [HAMAP]

Taxonomic identifier

266835 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Mesorhizobium

Protein attributes

Sequence length	937 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP MF_00711
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP MF_00711
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_00711
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvP family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 937	937	Glycine dehydrogenase [decarboxylating] HAMAP MF_00711		PRO_0000166931
Amino acid modifications
	Modified residue	686	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q98LT6 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: D135C7B4C9DD0471	FASTA	937	99,386
	10 20 30 40 50 60 MMTTALTPFS ARHIGPGVND VRAMLAVIGV PSVETLISQA VPQSIRLDLP LTLPAPASEA 70 80 90 100 110 120 EALAELSAIM AKNTVLKSFI GAGYHGVHVP PVIQRNLFEN PAWYTAYTPY QAEISQGRLE 130 140 150 160 170 180 MLFNFQTLVT ELTGLPVASA SLLDEATAVA EAVGIALRHH RDKRTKVAFA GTPHPQTLDV 190 200 210 220 230 240 VRTRAEPLGI EIDGETIDDN TAALLVSWPD TLGVYGDHKA AIDKARAAGA LVVFIADPLG 250 260 270 280 290 300 LTLTDAPAKL GADIAVGPMQ RFGVPMGFGG PHAAYCAVSD RLTRLMPGRL VGQSTDSKGR 310 320 330 340 350 360 PGYRLALQTR EQHIRRDKAT SNICTAQALL ANMATAYAIW HGPAGLQAIA GRIHALANRL 370 380 390 400 410 420 ASGLKAAGVS VLGASRFDTV TVEAKGKAAE IAEAAEKTGR LLRVLDADHV GIAFDETSTD 430 440 450 460 470 480 ADLDAIASLF GAKAAPSADS TVPGKPRGKE FLTQPVFNEN KSETDMMRLL RRLADKDLAL 490 500 510 520 530 540 DRSMIPLGSC TMKLNAAAEM MPVSWPSIAD LHPFAPASHS AGYRAMIGEL EGWLSEITGF 550 560 570 580 590 600 DAVSLQPNAG SQGEYAGLLA IRAYHRSRGE GHRTVCLIPS SAHGTNPASA AMAGMSVVVV 610 620 630 640 650 660 RCLEDGNIDM DDMRAKANEH SKNLAALMFT YPSTHGVYEE GARHLCALIH EHGGQVYFDG 670 680 690 700 710 720 ANLNALVALA RPADIGADVC HMNLHKTFCI PHGGGGPGVG PIGVKAHLKP YLPGHVTEGS 730 740 750 760 770 780 AHAVSAAPFG SASILPITWM YIRMMGAAGL KQATETAIIS ANYVATRLAP HFPLLYKGRH 790 800 810 820 830 840 DRIAHECILD TRVLKESAGI SVDDIAKRLI DYGFHAPTMS FPVAGTLMVE PTESEPKREL 850 860 870 880 890 900 DRFCEAMIAI AGEAAKVARG DWPLADNPLV NAPHTAAETL AGQWTHPYSR LEAAYPAGDA 910 920 930 DTAAKYWPPV SRIDNVAGDR NLVCSCPPLS DYLGAAE

References

[1]

"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti." Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S. DNA Res. 7:331-338(2000) [PubMed: 11214968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MAFF303099.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000012 Genomic DNA. Translation: BAB48377.1.
RefSeq	NP_102591.1. NC_002678.2.
3D structure databases
ProteinModelPortal	Q98LT6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1225254.
GenomeReviews	Gene locus mlr0885 in contig BA000012_GR.
KEGG	mlo:mlr0885.
NMPDR	fig|266835.1.peg.696.
PATRIC	22475570. VBIMesLot2464_0704.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG286723.
OMA	CALIHEH.
ProtClustDB	PRK05367.
Family and domain databases
HAMAP	MF_00711. GcvP. [Tree]
InterPro	IPR020580. GDC-P_N. IPR020581. GDC_P. IPR003437. GDC_P_homo. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 2 hits.
KO	K00281.
PANTHER	PTHR11773. GDC-P. 1 hit.
Pfam	PF02347. GDC-P. 2 hits. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 2 hits.
TIGRFAMs	TIGR00461. GcvP. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCSP_RHILO

Accession

Primary (citable) accession number: Q98LT6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
Last sequence update:	October 1, 2001
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program