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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:mlr0885
OrganismiMesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001669311 – 937Glycine dehydrogenase (decarboxylating)Add BLAST937

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei686N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi266835.mlr0885

Structurei

3D structure databases

ProteinModelPortaliQ98LT6
SMRiQ98LT6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG0403 LUCA
COG1003 LUCA
HOGENOMiHOG000239369
KOiK00281
OMAiQTMVCDL
OrthoDBiPOG091H03O6

Family and domain databases

CDDicd00613 GDC-P, 2 hits
Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

Q98LT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTTALTPFS ARHIGPGVND VRAMLAVIGV PSVETLISQA VPQSIRLDLP
60 70 80 90 100
LTLPAPASEA EALAELSAIM AKNTVLKSFI GAGYHGVHVP PVIQRNLFEN
110 120 130 140 150
PAWYTAYTPY QAEISQGRLE MLFNFQTLVT ELTGLPVASA SLLDEATAVA
160 170 180 190 200
EAVGIALRHH RDKRTKVAFA GTPHPQTLDV VRTRAEPLGI EIDGETIDDN
210 220 230 240 250
TAALLVSWPD TLGVYGDHKA AIDKARAAGA LVVFIADPLG LTLTDAPAKL
260 270 280 290 300
GADIAVGPMQ RFGVPMGFGG PHAAYCAVSD RLTRLMPGRL VGQSTDSKGR
310 320 330 340 350
PGYRLALQTR EQHIRRDKAT SNICTAQALL ANMATAYAIW HGPAGLQAIA
360 370 380 390 400
GRIHALANRL ASGLKAAGVS VLGASRFDTV TVEAKGKAAE IAEAAEKTGR
410 420 430 440 450
LLRVLDADHV GIAFDETSTD ADLDAIASLF GAKAAPSADS TVPGKPRGKE
460 470 480 490 500
FLTQPVFNEN KSETDMMRLL RRLADKDLAL DRSMIPLGSC TMKLNAAAEM
510 520 530 540 550
MPVSWPSIAD LHPFAPASHS AGYRAMIGEL EGWLSEITGF DAVSLQPNAG
560 570 580 590 600
SQGEYAGLLA IRAYHRSRGE GHRTVCLIPS SAHGTNPASA AMAGMSVVVV
610 620 630 640 650
RCLEDGNIDM DDMRAKANEH SKNLAALMFT YPSTHGVYEE GARHLCALIH
660 670 680 690 700
EHGGQVYFDG ANLNALVALA RPADIGADVC HMNLHKTFCI PHGGGGPGVG
710 720 730 740 750
PIGVKAHLKP YLPGHVTEGS AHAVSAAPFG SASILPITWM YIRMMGAAGL
760 770 780 790 800
KQATETAIIS ANYVATRLAP HFPLLYKGRH DRIAHECILD TRVLKESAGI
810 820 830 840 850
SVDDIAKRLI DYGFHAPTMS FPVAGTLMVE PTESEPKREL DRFCEAMIAI
860 870 880 890 900
AGEAAKVARG DWPLADNPLV NAPHTAAETL AGQWTHPYSR LEAAYPAGDA
910 920 930
DTAAKYWPPV SRIDNVAGDR NLVCSCPPLS DYLGAAE
Length:937
Mass (Da):99,386
Last modified:October 1, 2001 - v1
Checksum:iD135C7B4C9DD0471
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB48377.1

Genome annotation databases

EnsemblBacteriaiBAB48377; BAB48377; BAB48377
KEGGimlo:mlr0885
PATRICifig|266835.9.peg.704

Similar proteinsi

Entry informationi

Entry nameiGCSP_RHILO
AccessioniPrimary (citable) accession number: Q98LT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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