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Q98LT6

- GCSP_RHILO

UniProt

Q98LT6 - GCSP_RHILO

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, mlr0885
Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMLOT266835:GJ9L-704-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:mlr0885
OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
ProteomesiUP000000552: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 937937Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_0000166931Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei686 – 6861N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi266835.mlr0885.

Structurei

3D structure databases

ProteinModelPortaliQ98LT6.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiGTXELVA.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q98LT6-1 [UniParc]FASTAAdd to Basket

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MMTTALTPFS ARHIGPGVND VRAMLAVIGV PSVETLISQA VPQSIRLDLP    50
LTLPAPASEA EALAELSAIM AKNTVLKSFI GAGYHGVHVP PVIQRNLFEN 100
PAWYTAYTPY QAEISQGRLE MLFNFQTLVT ELTGLPVASA SLLDEATAVA 150
EAVGIALRHH RDKRTKVAFA GTPHPQTLDV VRTRAEPLGI EIDGETIDDN 200
TAALLVSWPD TLGVYGDHKA AIDKARAAGA LVVFIADPLG LTLTDAPAKL 250
GADIAVGPMQ RFGVPMGFGG PHAAYCAVSD RLTRLMPGRL VGQSTDSKGR 300
PGYRLALQTR EQHIRRDKAT SNICTAQALL ANMATAYAIW HGPAGLQAIA 350
GRIHALANRL ASGLKAAGVS VLGASRFDTV TVEAKGKAAE IAEAAEKTGR 400
LLRVLDADHV GIAFDETSTD ADLDAIASLF GAKAAPSADS TVPGKPRGKE 450
FLTQPVFNEN KSETDMMRLL RRLADKDLAL DRSMIPLGSC TMKLNAAAEM 500
MPVSWPSIAD LHPFAPASHS AGYRAMIGEL EGWLSEITGF DAVSLQPNAG 550
SQGEYAGLLA IRAYHRSRGE GHRTVCLIPS SAHGTNPASA AMAGMSVVVV 600
RCLEDGNIDM DDMRAKANEH SKNLAALMFT YPSTHGVYEE GARHLCALIH 650
EHGGQVYFDG ANLNALVALA RPADIGADVC HMNLHKTFCI PHGGGGPGVG 700
PIGVKAHLKP YLPGHVTEGS AHAVSAAPFG SASILPITWM YIRMMGAAGL 750
KQATETAIIS ANYVATRLAP HFPLLYKGRH DRIAHECILD TRVLKESAGI 800
SVDDIAKRLI DYGFHAPTMS FPVAGTLMVE PTESEPKREL DRFCEAMIAI 850
AGEAAKVARG DWPLADNPLV NAPHTAAETL AGQWTHPYSR LEAAYPAGDA 900
DTAAKYWPPV SRIDNVAGDR NLVCSCPPLS DYLGAAE 937
Length:937
Mass (Da):99,386
Last modified:October 1, 2001 - v1
Checksum:iD135C7B4C9DD0471
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000012 Genomic DNA. Translation: BAB48377.1.
RefSeqiNP_102591.1. NC_002678.2.

Genome annotation databases

EnsemblBacteriaiBAB48377; BAB48377; BAB48377.
GeneIDi1225254.
KEGGimlo:mlr0885.
PATRICi22475570. VBIMesLot2464_0704.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000012 Genomic DNA. Translation: BAB48377.1 .
RefSeqi NP_102591.1. NC_002678.2.

3D structure databases

ProteinModelPortali Q98LT6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266835.mlr0885.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB48377 ; BAB48377 ; BAB48377 .
GeneIDi 1225254.
KEGGi mlo:mlr0885.
PATRICi 22475570. VBIMesLot2464_0704.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi GTXELVA.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci MLOT266835:GJ9L-704-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MAFF303099.

Entry informationi

Entry nameiGCSP_RHILO
AccessioniPrimary (citable) accession number: Q98LT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: October 1, 2001
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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