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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMLOT266835:GJ9L-704-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:mlr0885
OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
ProteomesiUP000000552 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 937937Glycine dehydrogenase (decarboxylating)PRO_0000166931Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei686 – 6861N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi266835.mlr0885.

Structurei

3D structure databases

ProteinModelPortaliQ98LT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiPHYKTLY.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q98LT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTTALTPFS ARHIGPGVND VRAMLAVIGV PSVETLISQA VPQSIRLDLP
60 70 80 90 100
LTLPAPASEA EALAELSAIM AKNTVLKSFI GAGYHGVHVP PVIQRNLFEN
110 120 130 140 150
PAWYTAYTPY QAEISQGRLE MLFNFQTLVT ELTGLPVASA SLLDEATAVA
160 170 180 190 200
EAVGIALRHH RDKRTKVAFA GTPHPQTLDV VRTRAEPLGI EIDGETIDDN
210 220 230 240 250
TAALLVSWPD TLGVYGDHKA AIDKARAAGA LVVFIADPLG LTLTDAPAKL
260 270 280 290 300
GADIAVGPMQ RFGVPMGFGG PHAAYCAVSD RLTRLMPGRL VGQSTDSKGR
310 320 330 340 350
PGYRLALQTR EQHIRRDKAT SNICTAQALL ANMATAYAIW HGPAGLQAIA
360 370 380 390 400
GRIHALANRL ASGLKAAGVS VLGASRFDTV TVEAKGKAAE IAEAAEKTGR
410 420 430 440 450
LLRVLDADHV GIAFDETSTD ADLDAIASLF GAKAAPSADS TVPGKPRGKE
460 470 480 490 500
FLTQPVFNEN KSETDMMRLL RRLADKDLAL DRSMIPLGSC TMKLNAAAEM
510 520 530 540 550
MPVSWPSIAD LHPFAPASHS AGYRAMIGEL EGWLSEITGF DAVSLQPNAG
560 570 580 590 600
SQGEYAGLLA IRAYHRSRGE GHRTVCLIPS SAHGTNPASA AMAGMSVVVV
610 620 630 640 650
RCLEDGNIDM DDMRAKANEH SKNLAALMFT YPSTHGVYEE GARHLCALIH
660 670 680 690 700
EHGGQVYFDG ANLNALVALA RPADIGADVC HMNLHKTFCI PHGGGGPGVG
710 720 730 740 750
PIGVKAHLKP YLPGHVTEGS AHAVSAAPFG SASILPITWM YIRMMGAAGL
760 770 780 790 800
KQATETAIIS ANYVATRLAP HFPLLYKGRH DRIAHECILD TRVLKESAGI
810 820 830 840 850
SVDDIAKRLI DYGFHAPTMS FPVAGTLMVE PTESEPKREL DRFCEAMIAI
860 870 880 890 900
AGEAAKVARG DWPLADNPLV NAPHTAAETL AGQWTHPYSR LEAAYPAGDA
910 920 930
DTAAKYWPPV SRIDNVAGDR NLVCSCPPLS DYLGAAE
Length:937
Mass (Da):99,386
Last modified:October 1, 2001 - v1
Checksum:iD135C7B4C9DD0471
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB48377.1.
RefSeqiNP_102591.1. NC_002678.2.

Genome annotation databases

EnsemblBacteriaiBAB48377; BAB48377; BAB48377.
KEGGimlo:mlr0885.
PATRICi22475570. VBIMesLot2464_0704.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB48377.1.
RefSeqiNP_102591.1. NC_002678.2.

3D structure databases

ProteinModelPortaliQ98LT6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266835.mlr0885.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB48377; BAB48377; BAB48377.
KEGGimlo:mlr0885.
PATRICi22475570. VBIMesLot2464_0704.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiPHYKTLY.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciMLOT266835:GJ9L-704-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MAFF303099.

Entry informationi

Entry nameiGCSP_RHILO
AccessioniPrimary (citable) accession number: Q98LT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: October 1, 2001
Last modified: April 29, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.