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Q98LT6

- GCSP_RHILO

UniProt

Q98LT6 - GCSP_RHILO

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciMLOT266835:GJ9L-704-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:mlr0885
    OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
    Taxonomic identifieri266835 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
    ProteomesiUP000000552: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 937937Glycine dehydrogenase (decarboxylating)PRO_0000166931Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei686 – 6861N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi266835.mlr0885.

    Structurei

    3D structure databases

    ProteinModelPortaliQ98LT6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiGTXELVA.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q98LT6-1 [UniParc]FASTAAdd to Basket

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    MMTTALTPFS ARHIGPGVND VRAMLAVIGV PSVETLISQA VPQSIRLDLP    50
    LTLPAPASEA EALAELSAIM AKNTVLKSFI GAGYHGVHVP PVIQRNLFEN 100
    PAWYTAYTPY QAEISQGRLE MLFNFQTLVT ELTGLPVASA SLLDEATAVA 150
    EAVGIALRHH RDKRTKVAFA GTPHPQTLDV VRTRAEPLGI EIDGETIDDN 200
    TAALLVSWPD TLGVYGDHKA AIDKARAAGA LVVFIADPLG LTLTDAPAKL 250
    GADIAVGPMQ RFGVPMGFGG PHAAYCAVSD RLTRLMPGRL VGQSTDSKGR 300
    PGYRLALQTR EQHIRRDKAT SNICTAQALL ANMATAYAIW HGPAGLQAIA 350
    GRIHALANRL ASGLKAAGVS VLGASRFDTV TVEAKGKAAE IAEAAEKTGR 400
    LLRVLDADHV GIAFDETSTD ADLDAIASLF GAKAAPSADS TVPGKPRGKE 450
    FLTQPVFNEN KSETDMMRLL RRLADKDLAL DRSMIPLGSC TMKLNAAAEM 500
    MPVSWPSIAD LHPFAPASHS AGYRAMIGEL EGWLSEITGF DAVSLQPNAG 550
    SQGEYAGLLA IRAYHRSRGE GHRTVCLIPS SAHGTNPASA AMAGMSVVVV 600
    RCLEDGNIDM DDMRAKANEH SKNLAALMFT YPSTHGVYEE GARHLCALIH 650
    EHGGQVYFDG ANLNALVALA RPADIGADVC HMNLHKTFCI PHGGGGPGVG 700
    PIGVKAHLKP YLPGHVTEGS AHAVSAAPFG SASILPITWM YIRMMGAAGL 750
    KQATETAIIS ANYVATRLAP HFPLLYKGRH DRIAHECILD TRVLKESAGI 800
    SVDDIAKRLI DYGFHAPTMS FPVAGTLMVE PTESEPKREL DRFCEAMIAI 850
    AGEAAKVARG DWPLADNPLV NAPHTAAETL AGQWTHPYSR LEAAYPAGDA 900
    DTAAKYWPPV SRIDNVAGDR NLVCSCPPLS DYLGAAE 937
    Length:937
    Mass (Da):99,386
    Last modified:October 1, 2001 - v1
    Checksum:iD135C7B4C9DD0471
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB48377.1.
    RefSeqiNP_102591.1. NC_002678.2.

    Genome annotation databases

    EnsemblBacteriaiBAB48377; BAB48377; BAB48377.
    GeneIDi1225254.
    KEGGimlo:mlr0885.
    PATRICi22475570. VBIMesLot2464_0704.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB48377.1 .
    RefSeqi NP_102591.1. NC_002678.2.

    3D structure databases

    ProteinModelPortali Q98LT6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266835.mlr0885.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB48377 ; BAB48377 ; BAB48377 .
    GeneIDi 1225254.
    KEGGi mlo:mlr0885.
    PATRICi 22475570. VBIMesLot2464_0704.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi GTXELVA.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci MLOT266835:GJ9L-704-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MAFF303099.

    Entry informationi

    Entry nameiGCSP_RHILO
    AccessioniPrimary (citable) accession number: Q98LT6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3