Q98KQ8 (NUOD_RHILO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADH-quinone oxidoreductase subunit D
EC=1.6.99.5

Alternative name(s):
NADH dehydrogenase I subunit D
NDH-1 subunit D

Gene names

Name:	nuoD
Ordered Locus Names:	mll1367

Organism

Rhizobium loti (strain MAFF303099) (Mesorhizobium loti) [Complete proteome] [HAMAP]

Taxonomic identifier

266835 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Mesorhizobium

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP MF_01358
Catalytic activity	NADH + quinone = NAD+ + quinol. HAMAP MF_01358
Subunit structure	NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity HAMAP MF_01358.
Sequence similarities	Belongs to the complex I 49 kDa subunit family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	NAD Ubiquinone
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro NADH dehydrogenase (quinone) activity Inferred from electronic annotation. Source: EC quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 396	396	NADH-quinone oxidoreductase subunit D HAMAP MF_01358		PRO_0000357897

Sequences

	Sequence		Length	Mass (Da)
	Q98KQ8 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 9D11DDF11BE655AA	FASTA	396	44,506
	10 20 30 40 50 60 MAETSVRNFN INFGPQHPAA HGVLRLVLEL DGEVVDRVDP HIGLLHRGTE KLIEAKTYLQ 70 80 90 100 110 120 AVPYLDRLDY CAPMNQEHAF ALAAERLLGI EVPKRGQLIR VLYCEIGRIM SHILNVTTQA 130 140 150 160 170 180 MDVGALTPPL WGFVEREKLM VFYERASGSR MHAAYFRPGG VHQDLPRQLV EDIGKWIDPF 190 200 210 220 230 240 LKSIDDLDRL LTGNRIFKQR NVDIGIVSLA DAWAWGFSGV MVRGSGAAWD LRKSQPYECY 250 260 270 280 290 300 SEMDFDIPIG KNGDCYDRYL VRMEEMRQSA RIMRQCVDLL LGKESTGPVS NLDGKVVPPK 310 320 330 340 350 360 RAAMKRSMEA LIHHFKLYTE GYRVPAGEVY AAVEAPKGEF GVYLVSDGTN KPYRCKLRAP 370 380 390 GFAHLQAMDF LCRGHLLADV TAVLGSLDIV FGEVDR

References

[1]

"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti." Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S. DNA Res. 7:331-338(2000) [PubMed: 11214968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MAFF303099.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000012 Genomic DNA. Translation: BAB48756.1.
RefSeq	NP_102970.1. NC_002678.2.
3D structure databases
HSSP	HSSP built from PDB template 2FUG based on UniProtKB Q56220.
ProteinModelPortal	Q98KQ8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1225633.
GenomeReviews	Gene locus mll1367 in contig BA000012_GR.
KEGG	mlo:mll1367.
NMPDR	fig|266835.1.peg.1075.
PATRIC	22476380. VBIMesLot2464_1101.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG459705.
OMA	MADVITI.
ProtClustDB	PRK06075.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-16397.
Family and domain databases
HAMAP	MF_01358. NDH1_NuoD. [Tree]
InterPro	IPR010219. NADH_DH_1_suD. IPR001135. NADH_Q_OxRdtase_suD. IPR014029. NADH_UbQ_OxRdtase_49kDa_CS. IPR022885. NDH1_su_D/H. [Graphical view]
KO	K00333.
Pfam	PF00346. Complex1_49kDa. 1 hit. [Graphical view]
TIGRFAMs	TIGR01962. NuoD. 1 hit.
PROSITE	PS00535. COMPLEX1_49K. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUOD_RHILO

Accession

Primary (citable) accession number: Q98KQ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 16, 2008
Last sequence update:	October 1, 2001
Last modified:	January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program