Reviewed, UniProtKB/Swiss-Prot Q98KK0 (BODG_RHILO)

Names and origin

Protein names

Recommended name:
    Probable gamma-butyrobetaine dioxygenase
    EC=1.14.11.1
Alternative name(s):
    Gamma-butyrobetaine,2-oxoglutarate dioxygenase
    Gamma-butyrobetaine hydroxylase
      Short name=Gamma-BBH

Gene names

Ordered Locus Names:

mll1440

Organism

Rhizobium loti (Mesorhizobium loti) [Complete proteome] [HAMAP]

Taxonomic identifier

381 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Mesorhizobium

Protein attributes

Sequence length	383 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the formation of L-carnitine from gamma-butyrobetaine By similarity.
Catalytic activity	4-trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2.
Cofactor	Iron By similarity. Ascorbate By similarity.
Pathway	Amine and polyamine biosynthesis; carnitine biosynthesis.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the gamma-BBH/TMLD family.

Ontologies

Keywords
Biological process	Carnitine biosynthesis
Cellular component	Cytoplasm
Ligand	Iron
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carnitine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro gamma-butyrobetaine dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 383	383	Probable gamma-butyrobetaine dioxygenase		PRO_0000207090

Sequences

	Sequence		Length	Mass (Da)
	Q98KK0-1 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 866A57727B377860	FASTA	383	42,394
	10 20 30 40 50 60 MLTHALIGDE GRTIELGWQG GRRTRFHAMW LRDNALDDKT RSAGNGQRLI TILDIPAETR 70 80 90 100 110 120 IGAAEIKGGA LEVSFVPEGK TVSFPAQWLS ANAYDRDELR EPGWTGDVIQ RWTKATMQNS 130 140 150 160 170 180 VPRASYKAAF HGRSVLREWL SAVRTYGFAV MDGLPAESGA LCKVSDLFGY IRETNYGRWF 190 200 210 220 230 240 EVRAEVNPNN LAYTNLGLQA HTDNPYRDPV PTLQILACVE NTVEGGESSV IDGFAVAAAL 250 260 270 280 290 300 QAENPEGFRL LSSCPARFEY AGSSGVRLQA KRPMIELGPD GELICIRFNN RSLAPVVDVP 310 320 330 340 350 360 FADMDAYYAA YRRFAELIED PDFEVTFKLQ PGQAFIVDNT RVMHARKAFS GTGKRWLQGC 370 380 YADKDGLLST LAAIEHSFKE AAE

References

[1]

"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti." Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S. DNA Res. 7:331-338(2000) [PubMed: 11214968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MAFF303099.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000012 Genomic DNA. Translation: BAB48814.1.
RefSeq	NP_103028.1.
3D structure databases
HSSP	HSSP built from PDB template 1DRY based on UniProtKB Q05581.
ModBase	Search...
Genome annotation databases
GeneID	1225691.
GenomeReviews	Gene locus mll1440 in contig BA000012_GR.
KEGG	mlo:mll1440.
NMPDR	fig|266835.1.peg.1133.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q98KK0.
OMA	Q98KK0. HTDNPYR.
Enzyme and pathway databases
BRENDA	1.14.11.1. 3315.
Family and domain databases
InterPro	IPR012775. 2-oxoglut_dOase. IPR003819. Taurine_dOase. [Graphical view]
Pfam	PF02668. TauD. 1 hit. [Graphical view]
TIGRFAMs	TIGR02409. carnitine_bodg. 1 hit.
ProtoNet	Search...

Entry information

Entry name

BODG_RHILO

Accession

Primary (citable) accession number: Q98KK0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2002
Last sequence update:	October 1, 2001
Last modified:	June 16, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)