Reviewed, UniProtKB/Swiss-Prot Q98JV5 (MSRA1_RHILO)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrA 1
      Short name=Protein-methionine-S-oxide reductase 1
    EC=1.8.4.11
Alternative name(s):
    Peptide-methionine (S)-S-oxide reductase 1
      Short name=Peptide Met(O) reductase 1

Gene names

Name:	msrA1
Ordered Locus Names:	mll1760

Organism

Rhizobium loti (Mesorhizobium loti) [Complete proteome] [HAMAP]

Taxonomic identifier

381 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Mesorhizobium

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity.
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the msrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 172	172	Peptide methionine sulfoxide reductase msrA 1 HAMAP MF_01401		PRO_0000138571
Sites
	Active site	14	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q98JV5-1 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 0B2C31E29596AA40	FASTA	172	19,280
	10 20 30 40 50 60 MATSTERAVL AGGCFWGMQD LIRRYPGVIS TRVGYSGGDV ANATYRNHGT HAEAIEINFD 70 80 90 100 110 120 PAVISYRTLL ERFFQIHDPT TRNRQGNDVG MSYRSAIYYT SDEQKRVAED TIADVDASGL 130 140 150 160 170 WPGKVVTEVA PAGAFWEAEP EHQDYLEKYP NGYTCHFVRP GWKLPVREKA VS

References

[1]

"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti." Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S. DNA Res. 7:331-338(2000) [PubMed: 11214968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MAFF303099.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000012 Genomic DNA. Translation: BAB49060.1.
RefSeq	NP_103274.1.
3D structure databases
HSSP	HSSP built from PDB template 1NWA based on UniProtKB P96814.
SMR	Q98JV5. Positions 3-167.
ModBase	Search...
Genome annotation databases
GeneID	1225935.
GenomeReviews	Gene locus mll1760 in contig BA000012_GR.
KEGG	mlo:mll1760.
NMPDR	fig|266835.1.peg.1378.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q98JV5.
OMA	Q98JV5. VPNATYR.
Enzyme and pathway databases
BRENDA	1.8.4.11. 3315.
Family and domain databases
HAMAP	MF_01401. [Tree]
InterPro	IPR002569. MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
ProDom	PD003489. PMSR. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00401. msrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA1_RHILO

Accession

Primary (citable) accession number: Q98JV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	October 1, 2001
Last modified:	June 16, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)