Q98I23 (PUR72_RHILO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative phosphoribosylaminoimidazole-succinocarboxamide synthase 2
EC=6.3.2.6

Alternative name(s):
SAICAR synthetase 2

Gene names

Name:	purC2
Ordered Locus Names:	mll2603

Organism

Rhizobium loti (strain MAFF303099) (Mesorhizobium loti) [Complete proteome] [HAMAP]

Taxonomic identifier

266835 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Mesorhizobium

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family.
Sequence caution	The sequence BAB49693.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Putative phosphoribosylaminoimidazole-succinocarboxamide synthase 2 HAMAP MF_00137		PRO_0000100860

Sequences

	Sequence		Length	Mass (Da)
	Q98I23 [UniParc]. Last modified December 15, 2003. Version 2. Checksum: D1FB00CB54256D2E	FASTA	313	35,091
	10 20 30 40 50 60 MRTLSDAFIP ELPGYYKGKV RENYDLADGR RIIIATDRLS AFDIILTSIP FKGEILTQTA 70 80 90 100 110 120 RYWFEETADI CPNHVLEYPD PNVVVGTRLD ILPVEIVVRG YLAGTTSTSI LTRYRRGERE 130 140 150 160 170 180 MYGMRLPDGL RDNEKLAAPV ITPTSKAADG GHDEPLSRAE ILAQGLLTQA QWDTVSDYAL 190 200 210 220 230 240 KLFARGQARA AERGLILADT KYEFGTDKNG TIILADEIHT PDSSRYWIAA SYEQALASGT 250 260 270 280 290 300 RPDSFDKDFI RSWVAARCDP YKDPIPRIPD EIVEQASRIY AQAYEAITGK AFVPDLSGDT 310 VLDRIRSNLV RFF

References

[1]

"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti." Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S. DNA Res. 7:331-338(2000) [PubMed: 11214968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MAFF303099.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000012 Genomic DNA. Translation: BAB49693.1. Different initiation.
RefSeq	NP_103907.1. NC_002678.2.
3D structure databases
ProteinModelPortal	Q98I23.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1226568.
GenomeReviews	Gene locus mll2603 in contig BA000012_GR.
KEGG	mlo:mll2603.
NMPDR	fig|266835.1.peg.2011.
PATRIC	22478365. VBIMesLot2464_2089.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG555040.
ProtClustDB	PRK12607.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synth. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KO	K01923.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. PS01058. SAICAR_SYNTHETASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR72_RHILO

Accession

Primary (citable) accession number: Q98I23

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	December 15, 2003
Last modified:	January 25, 2012
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program