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Protein

Putative phosphoribosylaminoimidazole-succinocarboxamide synthase 2

Gene

purC2

Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Putative phosphoribosylaminoimidazole-succinocarboxamide synthase 2 (purC2), Phosphoribosylaminoimidazole-succinocarboxamide synthase 1 (purC1)
  2. Adenylosuccinate lyase (mll0079)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLOT266835:G1G20-2083-MONOMER
UniPathwayiUPA00074; UER00131

Names & Taxonomyi

Protein namesi
Recommended name:
Putative phosphoribosylaminoimidazole-succinocarboxamide synthase 2 (EC:6.3.2.6)
Alternative name(s):
SAICAR synthetase 2
Gene namesi
Name:purC2
Ordered Locus Names:mll2603
OrganismiMesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001008601 – 313Putative phosphoribosylaminoimidazole-succinocarboxamide synthase 2Add BLAST313

Interactioni

Protein-protein interaction databases

STRINGi266835.mll2603

Structurei

3D structure databases

ProteinModelPortaliQ98I23
SMRiQ98I23
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAICAR synthetase family.Curated

Phylogenomic databases

eggNOGiENOG4105C8V Bacteria
COG0152 LUCA
HOGENOMiHOG000230360
KOiK01923
OrthoDBiPOG091H01GT

Family and domain databases

HAMAPiMF_00137 SAICAR_synth, 1 hit
InterProiView protein in InterPro
IPR028923 SAICAR_synt/ADE2_N
IPR018236 SAICAR_synthetase_CS
PfamiView protein in Pfam
PF01259 SAICAR_synt, 1 hit
PROSITEiView protein in PROSITE
PS01057 SAICAR_SYNTHETASE_1, 1 hit
PS01058 SAICAR_SYNTHETASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q98I23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLSDAFIP ELPGYYKGKV RENYDLADGR RIIIATDRLS AFDIILTSIP
60 70 80 90 100
FKGEILTQTA RYWFEETADI CPNHVLEYPD PNVVVGTRLD ILPVEIVVRG
110 120 130 140 150
YLAGTTSTSI LTRYRRGERE MYGMRLPDGL RDNEKLAAPV ITPTSKAADG
160 170 180 190 200
GHDEPLSRAE ILAQGLLTQA QWDTVSDYAL KLFARGQARA AERGLILADT
210 220 230 240 250
KYEFGTDKNG TIILADEIHT PDSSRYWIAA SYEQALASGT RPDSFDKDFI
260 270 280 290 300
RSWVAARCDP YKDPIPRIPD EIVEQASRIY AQAYEAITGK AFVPDLSGDT
310
VLDRIRSNLV RFF
Length:313
Mass (Da):35,091
Last modified:December 15, 2003 - v2
Checksum:iD1FB00CB54256D2E
GO

Sequence cautioni

The sequence BAB49693 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB49693.1 Different initiation.
RefSeqiWP_044548260.1, NC_002678.2

Genome annotation databases

EnsemblBacteriaiBAB49693; BAB49693; BAB49693
KEGGimlo:mll2603
PATRICifig|266835.9.peg.2089

Similar proteinsi

Entry informationi

Entry nameiPUR72_RHILO
AccessioniPrimary (citable) accession number: Q98I23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: May 23, 2018
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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