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Q98HW3 (KPRS_RHILO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribose-phosphate pyrophosphokinase
Short name=RPPK
EC=2.7.6.1
Alternative name(s):
Phosphoribosyl pyrophosphate synthase
Short name=P-Rib-PP synthase
Short name=PRPP synthase
Gene names
Name:prs
Ordered Locus Names:mlr2685
OrganismRhizobium loti (strain MAFF303099) (Mesorhizobium loti) [Complete proteome] [HAMAP]
Taxonomic identifier266835 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Mesorhizobium ›

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00583

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_00583

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP-Rule MF_00583

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00583.

Sequence similarities

Belongs to the ribose-phosphate pyrophosphokinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Ribose-phosphate pyrophosphokinase HAMAP-Rule MF_00583
PRO_0000141180

Regions

Region210 – 22314Binding of phosphoribosylpyrophosphate Potential

Sites

Metal binding1251Magnesium Potential
Metal binding1271Magnesium Potential
Metal binding1361Magnesium Potential
Metal binding1401Magnesium Potential

Sequences

Sequence LengthMass (Da)Tools
Q98HW3 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 7DE35FB790E512F7

FASTA31133,519
        10         20         30         40         50         60 
MKLFAGNSNR VLAEAVARYL NIPLGKATVR RFADQEIFVE IQENVRGEDV FILQSTSFPT 

        70         80         90        100        110        120 
NDHLMELLIM IDAFMRSSAK RITAVIPYFG YARQDRRASG RTPISAKLVA NMITRAGVDR 

       130        140        150        160        170        180 
VLTLDLHAGQ IQGFFDIPTD NLFSVPVMAR DVKAKYKQLG NVVVVSPDIG GVVRARALAK 

       190        200        210        220        230        240 
RFDAQLAIVD KRRERPGESE VMNIIGAVAG KDCLLIDDIV DSGGTLCNAA DALLANGATS 

       250        260        270        280        290        300 
VTAYITHGVL SGGAVARISG SKLQELVITD SIQPTQGVLD APNIRVISIA DLMGEAISRT 

       310 
ATEESVSSLF D

« Hide

References

[1]"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti."
Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. expand/collapse author list , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S.
DNA Res. 7:331-338(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MAFF303099.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000012 Genomic DNA. Translation: BAB49753.1.
RefSeqNP_103967.1. NC_002678.2.

3D structure databases

ProteinModelPortalQ98HW3.
SMRQ98HW3. Positions 1-309.
ModBaseSearch...

Protein-protein interaction databases

STRING266835.mlr2685.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB49753; BAB49753; BAB49753.
GeneID1226628.
KEGGmlo:mlr2685.
PATRIC22478489. VBIMesLot2464_2151.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0462.
HOGENOMHOG000210449.
KOK00948.
OMATRISPTE.
ProtClustDBPRK01259.

Enzyme and pathway databases

BioCycMLOT266835:GJ9L-2091-MONOMER.
UniPathwayUPA00087; UER00172.

Family and domain databases

HAMAPMF_00583_B. RibP_PPkinase_B.
InterProIPR000842. PRib_PP_synth_CS.
IPR000836. PRibTrfase_dom.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR01251. ribP_PPkin. 1 hit.
PROSITEPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPRS_RHILO
AccessionPrimary (citable) accession number: Q98HW3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 1, 2001
Last modified: May 1, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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