SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q98HQ4

- FTHS_RHILO

UniProt

Q98HQ4 - FTHS_RHILO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Formate--tetrahydrofolate ligase

Gene
fhs, mlr2763
Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 758ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLOT266835:GJ9L-2150-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:mlr2763
OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
ProteomesiUP000000552: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Formate--tetrahydrofolate ligaseUniRule annotationPRO_0000199371Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266835.mlr2763.

Structurei

3D structure databases

ProteinModelPortaliQ98HQ4.
SMRiQ98HQ4. Positions 7-557.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiNTIVQRI.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q98HQ4-1 [UniParc]FASTAAdd to Basket

« Hide

MAEVKSDIEI ARAAKKKQIQ EIGQKIGIPT EHLLPYGHDK AKISAEFIKS    50
VKGNKDGKLI LVTAINPTPA GEGKTTTTVG LGDGLNRIGK KAIVCIREAS 100
LGPNFGVKGG AAGGGYAQVV PMEDMNLHFT GDFHAITTAH NLLSALIDNH 150
IYWGNELGID TRRVVWRRVM DMNDRALREM ICSLGGVANG FPREGGFDIT 200
VASEVMAILC LSTDLKDLEK RLGDIIVAYR RDKSPVYARD LKADGAMAVL 250
LKDAMQPNLV QTLENNPAFV HGGPFANIAH GCNSVVATTT ALKLADYVVT 300
EAGFGADLGA EKFFDIKCRK AGLKPAAAVI VATVRAMKMN GGVKKEDLGK 350
ENIEAVKKGC ANLGRHIENI RQFGVPAVVA INHFYSDTDA EIQAMKDYVA 400
SMGEEAVLCK HWAKGSAGIE ELANKVVALA ESGASQFAPL YPDAMPLFEK 450
INTIVQRIYR GSEAIADKSV RDQLHAWEQA GYGNLPVCMA KTQYSFSTDP 500
NLRGAPTGHT VPVREVRLSA GAGFVVIICG EVMTMPGLPK APSSEKIFLN 550
EAGQIEGLF 559
Length:559
Mass (Da):59,971
Last modified:October 1, 2001 - v1
Checksum:i28FD5270D2672978
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000012 Genomic DNA. Translation: BAB49812.1.
RefSeqiNP_104026.1. NC_002678.2.

Genome annotation databases

EnsemblBacteriaiBAB49812; BAB49812; BAB49812.
GeneIDi1226687.
KEGGimlo:mlr2763.
PATRICi22478611. VBIMesLot2464_2212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000012 Genomic DNA. Translation: BAB49812.1 .
RefSeqi NP_104026.1. NC_002678.2.

3D structure databases

ProteinModelPortali Q98HQ4.
SMRi Q98HQ4. Positions 7-557.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266835.mlr2763.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB49812 ; BAB49812 ; BAB49812 .
GeneIDi 1226687.
KEGGi mlo:mlr2763.
PATRICi 22478611. VBIMesLot2464_2212.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi NTIVQRI.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci MLOT266835:GJ9L-2150-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MAFF303099.

Entry informationi

Entry nameiFTHS_RHILO
AccessioniPrimary (citable) accession number: Q98HQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 1, 2001
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi