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Q98HQ4

- FTHS_RHILO

UniProt

Q98HQ4 - FTHS_RHILO

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi68 – 758ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMLOT266835:GJ9L-2150-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:mlr2763
    OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
    Taxonomic identifieri266835 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
    ProteomesiUP000000552: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_0000199371Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266835.mlr2763.

    Structurei

    3D structure databases

    ProteinModelPortaliQ98HQ4.
    SMRiQ98HQ4. Positions 7-557.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiNTIVQRI.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q98HQ4-1 [UniParc]FASTAAdd to Basket

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    MAEVKSDIEI ARAAKKKQIQ EIGQKIGIPT EHLLPYGHDK AKISAEFIKS    50
    VKGNKDGKLI LVTAINPTPA GEGKTTTTVG LGDGLNRIGK KAIVCIREAS 100
    LGPNFGVKGG AAGGGYAQVV PMEDMNLHFT GDFHAITTAH NLLSALIDNH 150
    IYWGNELGID TRRVVWRRVM DMNDRALREM ICSLGGVANG FPREGGFDIT 200
    VASEVMAILC LSTDLKDLEK RLGDIIVAYR RDKSPVYARD LKADGAMAVL 250
    LKDAMQPNLV QTLENNPAFV HGGPFANIAH GCNSVVATTT ALKLADYVVT 300
    EAGFGADLGA EKFFDIKCRK AGLKPAAAVI VATVRAMKMN GGVKKEDLGK 350
    ENIEAVKKGC ANLGRHIENI RQFGVPAVVA INHFYSDTDA EIQAMKDYVA 400
    SMGEEAVLCK HWAKGSAGIE ELANKVVALA ESGASQFAPL YPDAMPLFEK 450
    INTIVQRIYR GSEAIADKSV RDQLHAWEQA GYGNLPVCMA KTQYSFSTDP 500
    NLRGAPTGHT VPVREVRLSA GAGFVVIICG EVMTMPGLPK APSSEKIFLN 550
    EAGQIEGLF 559
    Length:559
    Mass (Da):59,971
    Last modified:October 1, 2001 - v1
    Checksum:i28FD5270D2672978
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB49812.1.
    RefSeqiNP_104026.1. NC_002678.2.

    Genome annotation databases

    EnsemblBacteriaiBAB49812; BAB49812; BAB49812.
    GeneIDi1226687.
    KEGGimlo:mlr2763.
    PATRICi22478611. VBIMesLot2464_2212.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB49812.1 .
    RefSeqi NP_104026.1. NC_002678.2.

    3D structure databases

    ProteinModelPortali Q98HQ4.
    SMRi Q98HQ4. Positions 7-557.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266835.mlr2763.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB49812 ; BAB49812 ; BAB49812 .
    GeneIDi 1226687.
    KEGGi mlo:mlr2763.
    PATRICi 22478611. VBIMesLot2464_2212.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi NTIVQRI.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci MLOT266835:GJ9L-2150-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MAFF303099.

    Entry informationi

    Entry nameiFTHS_RHILO
    AccessioniPrimary (citable) accession number: Q98HQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3