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Q98H61 (HEMH_RHILO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:mlr3019
OrganismRhizobium loti (strain MAFF303099) (Mesorhizobium loti) [Complete proteome] [HAMAP]
Taxonomic identifier266835 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Mesorhizobium

Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 353353Ferrochelatase HAMAP MF_00323
PRO_0000175188

Sites

Metal binding2231Iron By similarity
Metal binding3041Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q98H61 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 79CF1F153DAC4737

FASTA35339,201
        10         20         30         40         50         60 
MTSAIAVDPK AAKPVGVTAG HAPAGAGKVG VLLVNLGTPD GTEFKPMWRY LREFLSDPRV 

        70         80         90        100        110        120 
IELNKAIWYP ILYGLVLTTR PKKSGANYAR IWNQERNESP LRTYTRAQSE KLAEALGDLP 

       130        140        150        160        170        180 
DVTVDWAMRY GNPSTASVAE RLVAQGCDRI LSFPLYPQYS ATTTATANDQ LFRALMKLRR 

       190        200        210        220        230        240 
APAIRSVPPY YAEPVYIEAL ASSIERHLAT LDFEPEVVIT SYHGIPKPYS DKGDPYQAHC 

       250        260        270        280        290        300 
LETTRLLREK LGWDEKKLIT TFQSRFGAQE WLQPYTDKTV EKLGKDGVKS IAIVNPGFSV 

       310        320        330        340        350 
DCIETLDEIG REAAETFHHA GGKNFAHIPC LNDSAEGMTV IEAMVRRELS GWV

« Hide

References

[1]"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti."
Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. expand/collapse author list , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S.
DNA Res. 7:331-338(2000) [PubMed: 11214968] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MAFF303099.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000012 Genomic DNA. Translation: BAB50005.1.
RefSeqNP_104219.1. NC_002678.2.

3D structure databases

ProteinModelPortalQ98H61.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1226880.
GenomeReviewsGene locus mlr3019 in contig BA000012_GR.
KEGGmlo:mlr3019.
NMPDRfig|266835.1.peg.2323.
PATRIC22479007. VBIMesLot2464_2409.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMAIRPAKSA.
ProtClustDBPRK00035.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_RHILO
AccessionPrimary (citable) accession number: Q98H61
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: October 1, 2001
Last modified: January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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