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Q98GV5

- TYPH_RHILO

UniProt

Q98GV5 - TYPH_RHILO

Protein

Thymidine phosphorylase

Gene

deoA

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.UniRule annotation

    Catalytic activityi

    Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. phosphorylase activity Source: InterPro
    2. pyrimidine-nucleoside phosphorylase activity Source: InterPro
    3. thymidine phosphorylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pyrimidine nucleobase metabolic process Source: InterPro
    2. pyrimidine nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciMLOT266835:GJ9L-2452-MONOMER.
    UniPathwayiUPA00578; UER00638.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine phosphorylaseUniRule annotation (EC:2.4.2.4UniRule annotation)
    Alternative name(s):
    TdRPaseUniRule annotation
    Gene namesi
    Name:deoAUniRule annotation
    Ordered Locus Names:mlr3160
    OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
    Taxonomic identifieri266835 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
    ProteomesiUP000000552: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 439439Thymidine phosphorylasePRO_0000059059Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi266835.mlr3160.

    Structurei

    3D structure databases

    ProteinModelPortaliQ98GV5.
    SMRiQ98GV5. Positions 1-436.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0213.
    HOGENOMiHOG000047313.
    KOiK00758.
    OMAiHYRITED.
    OrthoDBiEOG61ZTGG.

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPiMF_01628. Thymid_phosp.
    InterProiIPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR018090. Pyrmidine_PPas_bac/euk.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR013465. Thymidine_Pase.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000478. TP_PyNP. 1 hit.
    SMARTiSM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsiTIGR02643. T_phosphoryl. 1 hit.
    TIGR02644. Y_phosphoryl. 1 hit.
    PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q98GV5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPQEIIRHK RDGHRLSAGE IAAFIGGVTS GAVTDGQAAA FAMAVFFNGM    50
    NRDEAVALTL AMRDSGDVLD WSDLPGPVTD KHSTGGVGDN VSLMLAPIVA 100
    ACGAYVPMIS GRGLGHTGGT LDKMDAIPGY ISQPDIALFR QAVLETGCAI 150
    IGQTADLAPA DRRLYAIRDV TGTVESVPLI TASILSKKLA AGLGSLVLDV 200
    KVGNGAFMER SRDATALANS LVEVASGAGL KVSALITGMN EPLASAAGNA 250
    VEVHNAVDFL TGRLRDRRLE DVTLALAAEM LQSTGLVSSN QDGLRRATET 300
    LTSGRAAATF ARMVAVLGGP ADFIEKPEKY LAVAPTEFAV RATTDGFVTG 350
    IATRDIGLAV VGLGGGRTRP DDKIDPSVGI TRLLPIGAEV HAGDALALVH 400
    ARSPADAEAA AATVVSAYAI GASKPAADKT VMRRILPRG 439
    Length:439
    Mass (Da):45,095
    Last modified:October 1, 2001 - v1
    Checksum:i6317FDC479B81F94
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB50111.1.
    RefSeqiNP_104325.1. NC_002678.2.

    Genome annotation databases

    EnsemblBacteriaiBAB50111; BAB50111; BAB50111.
    GeneIDi1226986.
    KEGGimlo:mlr3160.
    PATRICi22479227. VBIMesLot2464_2517.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB50111.1 .
    RefSeqi NP_104325.1. NC_002678.2.

    3D structure databases

    ProteinModelPortali Q98GV5.
    SMRi Q98GV5. Positions 1-436.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266835.mlr3160.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB50111 ; BAB50111 ; BAB50111 .
    GeneIDi 1226986.
    KEGGi mlo:mlr3160.
    PATRICi 22479227. VBIMesLot2464_2517.

    Phylogenomic databases

    eggNOGi COG0213.
    HOGENOMi HOG000047313.
    KOi K00758.
    OMAi HYRITED.
    OrthoDBi EOG61ZTGG.

    Enzyme and pathway databases

    UniPathwayi UPA00578 ; UER00638 .
    BioCyci MLOT266835:GJ9L-2452-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPi MF_01628. Thymid_phosp.
    InterProi IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR018090. Pyrmidine_PPas_bac/euk.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR013465. Thymidine_Pase.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000478. TP_PyNP. 1 hit.
    SMARTi SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsi TIGR02643. T_phosphoryl. 1 hit.
    TIGR02644. Y_phosphoryl. 1 hit.
    PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MAFF303099.

    Entry informationi

    Entry nameiTYPH_RHILO
    AccessioniPrimary (citable) accession number: Q98GV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3