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Q98GV5 (TYPH_RHILO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine phosphorylase

EC=2.4.2.4
Alternative name(s):
TdRPase
Gene names
Name:deoA
Ordered Locus Names:mlr3160
OrganismRhizobium loti (strain MAFF303099) (Mesorhizobium loti) [Complete proteome] [HAMAP]
Taxonomic identifier266835 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium

Protein attributes

Sequence length439 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis By similarity. HAMAP-Rule MF_01628

Catalytic activity

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_01628

Pathway

Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2. HAMAP-Rule MF_01628

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01628

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 439439Thymidine phosphorylase HAMAP-Rule MF_01628
PRO_0000059059

Sequences

Sequence LengthMass (Da)Tools
Q98GV5 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 6317FDC479B81F94

FASTA43945,095
        10         20         30         40         50         60 
MLPQEIIRHK RDGHRLSAGE IAAFIGGVTS GAVTDGQAAA FAMAVFFNGM NRDEAVALTL 

        70         80         90        100        110        120 
AMRDSGDVLD WSDLPGPVTD KHSTGGVGDN VSLMLAPIVA ACGAYVPMIS GRGLGHTGGT 

       130        140        150        160        170        180 
LDKMDAIPGY ISQPDIALFR QAVLETGCAI IGQTADLAPA DRRLYAIRDV TGTVESVPLI 

       190        200        210        220        230        240 
TASILSKKLA AGLGSLVLDV KVGNGAFMER SRDATALANS LVEVASGAGL KVSALITGMN 

       250        260        270        280        290        300 
EPLASAAGNA VEVHNAVDFL TGRLRDRRLE DVTLALAAEM LQSTGLVSSN QDGLRRATET 

       310        320        330        340        350        360 
LTSGRAAATF ARMVAVLGGP ADFIEKPEKY LAVAPTEFAV RATTDGFVTG IATRDIGLAV 

       370        380        390        400        410        420 
VGLGGGRTRP DDKIDPSVGI TRLLPIGAEV HAGDALALVH ARSPADAEAA AATVVSAYAI 

       430 
GASKPAADKT VMRRILPRG 

« Hide

References

[1]"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti."
Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. expand/collapse author list , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S.
DNA Res. 7:331-338(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MAFF303099.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000012 Genomic DNA. Translation: BAB50111.1.
RefSeqNP_104325.1. NC_002678.2.

3D structure databases

ProteinModelPortalQ98GV5.
SMRQ98GV5. Positions 1-436.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266835.mlr3160.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB50111; BAB50111; BAB50111.
GeneID1226986.
KEGGmlo:mlr3160.
PATRIC22479227. VBIMesLot2464_2517.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0213.
HOGENOMHOG000047313.
KOK00758.
OMACGLAVPM.
OrthoDBEOG61ZTGG.
ProtClustDBPRK05820.

Enzyme and pathway databases

BioCycMLOT266835:GJ9L-2452-MONOMER.
UniPathwayUPA00578; UER00638.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPMF_01628. Thymid_phosp.
InterProIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013465. Thymidine_Pase.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFPIRSF000478. TP_PyNP. 1 hit.
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsTIGR02643. T_phosphoryl. 1 hit.
TIGR02644. Y_phosphoryl. 1 hit.
PROSITEPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYPH_RHILO
AccessionPrimary (citable) accession number: Q98GV5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2001
Last modified: February 19, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways