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Protein

Adenine deaminase

Gene

mll3163

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.UniRule annotation

Catalytic activityi

Adenine + H2O = hypoxanthine + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81Zinc; catalyticUniRule annotation
Metal bindingi10 – 101Zinc; catalyticUniRule annotation
Metal bindingi186 – 1861Zinc; catalyticUniRule annotation
Active sitei189 – 1891Proton donorUniRule annotation
Sitei210 – 2101Important for catalytic activityUniRule annotation
Metal bindingi267 – 2671Zinc; catalyticUniRule annotation
Binding sitei268 – 2681SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMLOT266835:GJ9L-2455-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine deaminaseUniRule annotation (EC:3.5.4.2UniRule annotation)
Short name:
ADEUniRule annotation
Alternative name(s):
Adenine aminohydrolaseUniRule annotation
Short name:
AAHUniRule annotation
Gene namesi
Ordered Locus Names:mll3163
OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Adenine deaminasePRO_0000194381Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266835.mll3163.

Structurei

3D structure databases

ProteinModelPortaliQ98GV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EKD. Bacteria.
COG1816. LUCA.
HOGENOMiHOG000218814.
KOiK01488.
OMAiSPDFCGG.
OrthoDBiPOG091H02QG.

Family and domain databases

HAMAPiMF_01962. Adenine_deaminase. 1 hit.
InterProiIPR001365. A/AMP_deaminase_dom.
IPR028892. ADE.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01430. aden_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q98GV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLKAELHCH IEGAAAPELV IRQAQKYGKD TAPYIQNGSF VWHDFTSFLA
60 70 80 90 100
AYDFSAELFR TEEDYARLAD HYLTSLARDG AIYSEVFTSP DHATKAGLSP
110 120 130 140 150
KAYTDALGEG MLRAKAKTGI EGRMIVTGVR HVGVESIERA ARFAARCGNP
160 170 180 190 200
LVTGFGVAGD ERVGEMEDYV RAFEIAREAG LGITIHAGEL TGWETVQAAL
210 220 230 240 250
DHIRPSRIGH GVRAIENPDL VRRIADEGIV LECCPGSNIA LKVFDSFADH
260 270 280 290 300
PLPALQAAGC KVTLNSDDPP YFWTSLKREY DIAAEHFAMN EKALAAVTRT
310 320
AIEAAFVDRK TKAALLARLN GAAR
Length:324
Mass (Da):35,247
Last modified:October 1, 2001 - v1
Checksum:i2411959E4E4F90EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB50114.1.
RefSeqiWP_010911461.1. NC_002678.2.

Genome annotation databases

EnsemblBacteriaiBAB50114; BAB50114; BAB50114.
GeneIDi1226989.
KEGGimlo:mll3163.
PATRICi22479233. VBIMesLot2464_2520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB50114.1.
RefSeqiWP_010911461.1. NC_002678.2.

3D structure databases

ProteinModelPortaliQ98GV2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266835.mll3163.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB50114; BAB50114; BAB50114.
GeneIDi1226989.
KEGGimlo:mll3163.
PATRICi22479233. VBIMesLot2464_2520.

Phylogenomic databases

eggNOGiENOG4105EKD. Bacteria.
COG1816. LUCA.
HOGENOMiHOG000218814.
KOiK01488.
OMAiSPDFCGG.
OrthoDBiPOG091H02QG.

Enzyme and pathway databases

BioCyciMLOT266835:GJ9L-2455-MONOMER.

Family and domain databases

HAMAPiMF_01962. Adenine_deaminase. 1 hit.
InterProiIPR001365. A/AMP_deaminase_dom.
IPR028892. ADE.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01430. aden_deam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADE_RHILO
AccessioniPrimary (citable) accession number: Q98GV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: October 1, 2001
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.