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Protein

Cyclic nucleotide-gated potassium channel mll3241

Gene

mll3241

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cyclic nucleotide-regulated potassium channel activated by cAMP.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei348cAMP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi297 – 298cAMP2
Nucleotide bindingi307 – 308cAMP2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Potassium channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

cAMP, cAMP-binding, Nucleotide-binding, Potassium

Protein family/group databases

TCDBi1.A.1.25.1. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic nucleotide-gated potassium channel mll3241
Alternative name(s):
MlotiK1 channel
Gene namesi
Ordered Locus Names:mll3241
OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicAdd BLAST12
Transmembranei13 – 30Helical; Name=Segment S1Add BLAST18
Topological domaini31 – 38Periplasmic8
Transmembranei39 – 61Helical; Name=Segment S2Add BLAST23
Topological domaini62 – 74CytoplasmicAdd BLAST13
Transmembranei75 – 94Helical; Name=Segment S3Add BLAST20
Transmembranei95 – 112Helical; Name=Segment S4Add BLAST18
Topological domaini113 – 129CytoplasmicAdd BLAST17
Transmembranei130 – 150Helical; Name=Segment S5Add BLAST21
Topological domaini151 – 161PeriplasmicAdd BLAST11
Intramembranei162 – 180Pore-formingAdd BLAST19
Topological domaini181 – 185Periplasmic5
Transmembranei186 – 210Helical; Name=Segment S6Add BLAST25
Topological domaini211 – 355CytoplasmicAdd BLAST145

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi203F → A: Increased channel conductance. 1 Publication1
Mutagenesisi215Y → A: Increased channel conductance. 1 Publication1
Mutagenesisi227W → A: Loss of channel activity. 1 Publication1
Mutagenesisi348R → A: Loss of cAMP binding. Loss of channel activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003515011 – 355Cyclic nucleotide-gated potassium channel mll3241Add BLAST355

Interactioni

Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

DIPiDIP-29507N.
STRINGi266835.mll3241.

Structurei

Secondary structure

1355
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 12Combined sources4
Helixi13 – 28Combined sources16
Beta strandi30 – 32Combined sources3
Helixi35 – 61Combined sources27
Helixi72 – 90Combined sources19
Helixi95 – 105Combined sources11
Helixi107 – 110Combined sources4
Helixi115 – 124Combined sources10
Helixi126 – 151Combined sources26
Turni152 – 154Combined sources3
Helixi156 – 159Combined sources4
Helixi162 – 173Combined sources12
Beta strandi179 – 181Combined sources3
Helixi216 – 223Combined sources8
Helixi226 – 230Combined sources5
Helixi234 – 238Combined sources5
Helixi241 – 250Combined sources10
Beta strandi252 – 256Combined sources5
Beta strandi261 – 263Combined sources3
Beta strandi271 – 278Combined sources8
Beta strandi280 – 286Combined sources7
Beta strandi288 – 290Combined sources3
Beta strandi295 – 297Combined sources3
Helixi298 – 303Combined sources6
Beta strandi308 – 323Combined sources16
Helixi324 – 333Combined sources10
Helixi335 – 352Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U12X-ray2.70A/B218-355[»]
1VP6X-ray1.70A/C218-355[»]
2K0GNMR-A216-355[»]
2KXLNMR-A216-355[»]
2ZD9X-ray4.00A/B/C/D1-355[»]
3BEHX-ray3.10A/B/C/D1-355[»]
3CL1X-ray2.40A/B216-355[»]
3CLPX-ray2.00A/C216-355[»]
3CO2X-ray2.90A/B/C/D216-355[»]
4CHVelectron microscopy7.00A/B/C/D1-355[»]
4CHWelectron microscopy7.00A/B/C/D1-355[»]
4MUVX-ray1.25A/B216-355[»]
ProteinModelPortaliQ98GN8.
SMRiQ98GN8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ98GN8.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi175 – 180Selectivity filterCurated6

Sequence similaritiesi

Belongs to the potassium channel family.Curated
Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EYW. Bacteria.
COG0664. LUCA.
COG1226. LUCA.
HOGENOMiHOG000271293.
KOiK10716.
OMAiMMSGIGI.
OrthoDBiPOG091H04JJ.

Family and domain databases

Gene3Di1.20.120.540. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR013099. K_chnl_dom.
IPR027378. Nucleotide_channel_N.
IPR014710. RmlC-like_jellyroll.
IPR028325. VG_K_chnl.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF07885. Ion_trans_2. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q98GN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVLPFLRIY APLNAVLAAP GLLAVAALTI PDMSGRSRLA LAALLAVIWG
60 70 80 90 100
AYLLQLAATL LKRRAGVVRD RTPKIAIDVL AVLVPLAAFL LDGSPDWSLY
110 120 130 140 150
CAVWLLKPLR DSTFFPVLGR VLANEARNLI GVTTLFGVVL FAVALAAYVI
160 170 180 190 200
ERDIQPEKFG SIPQAMWWAV VTLSTTGYGD TIPQSFAGRV LAGAVMMSGI
210 220 230 240 250
GIFGLWAGIL ATGFYQEVRR GDFVRNWQLV AAVPLFQKLG PAVLVEIVRA
260 270 280 290 300
LRARTVPAGA VICRIGEPGD RMFFVVEGSV SVATPNPVEL GPGAFFGEMA
310 320 330 340 350
LISGEPRSAT VSAATTVSLL SLHSADFQML CSSSPEIAEI FRKTALERRG

AAASA
Length:355
Mass (Da):37,735
Last modified:October 1, 2001 - v1
Checksum:i35EE06373D563933
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB50178.1.
RefSeqiWP_010911524.1. NC_002678.2.

Genome annotation databases

EnsemblBacteriaiBAB50178; BAB50178; BAB50178.
GeneIDi1227053.
KEGGimlo:mll3241.
PATRICi22479361. VBIMesLot2464_2584.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB50178.1.
RefSeqiWP_010911524.1. NC_002678.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U12X-ray2.70A/B218-355[»]
1VP6X-ray1.70A/C218-355[»]
2K0GNMR-A216-355[»]
2KXLNMR-A216-355[»]
2ZD9X-ray4.00A/B/C/D1-355[»]
3BEHX-ray3.10A/B/C/D1-355[»]
3CL1X-ray2.40A/B216-355[»]
3CLPX-ray2.00A/C216-355[»]
3CO2X-ray2.90A/B/C/D216-355[»]
4CHVelectron microscopy7.00A/B/C/D1-355[»]
4CHWelectron microscopy7.00A/B/C/D1-355[»]
4MUVX-ray1.25A/B216-355[»]
ProteinModelPortaliQ98GN8.
SMRiQ98GN8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29507N.
STRINGi266835.mll3241.

Protein family/group databases

TCDBi1.A.1.25.1. the voltage-gated ion channel (vic) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB50178; BAB50178; BAB50178.
GeneIDi1227053.
KEGGimlo:mll3241.
PATRICi22479361. VBIMesLot2464_2584.

Phylogenomic databases

eggNOGiENOG4105EYW. Bacteria.
COG0664. LUCA.
COG1226. LUCA.
HOGENOMiHOG000271293.
KOiK10716.
OMAiMMSGIGI.
OrthoDBiPOG091H04JJ.

Miscellaneous databases

EvolutionaryTraceiQ98GN8.

Family and domain databases

Gene3Di1.20.120.540. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR013099. K_chnl_dom.
IPR027378. Nucleotide_channel_N.
IPR014710. RmlC-like_jellyroll.
IPR028325. VG_K_chnl.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF07885. Ion_trans_2. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNGK1_RHILO
AccessioniPrimary (citable) accession number: Q98GN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: October 1, 2001
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.