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Protein

Fosfomycin resistance protein FosX

Gene

fosX

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the hydration of fosfomycin.1 Publication

Cofactori

Mn2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7Manganese1
Active sitei44Proton acceptorCurated1
Metal bindingi69Manganese1
Metal bindingi118Manganese1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fosfomycin resistance protein FosX
Gene namesi
Name:fosX
Ordered Locus Names:mlr3345
OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi44E → G: Decrease in activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001640471 – 139Fosfomycin resistance protein FosXAdd BLAST139

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi266835.mlr3345.

Structurei

Secondary structure

1139
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 13Combined sources12
Helixi15 – 26Combined sources12
Beta strandi29 – 33Combined sources5
Helixi34 – 36Combined sources3
Beta strandi44 – 49Combined sources6
Beta strandi52 – 58Combined sources7
Beta strandi69 – 73Combined sources5
Helixi76 – 78Combined sources3
Helixi79 – 89Combined sources11
Beta strandi106 – 110Combined sources5
Beta strandi116 – 120Combined sources5
Helixi124 – 129Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R9CX-ray1.83A/B1-139[»]
ProteinModelPortaliQ98GG1.
SMRiQ98GG1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ98GG1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG41081YN. Bacteria.
ENOG4111SM5. LUCA.
HOGENOMiHOG000232023.
OMAiNHIAFRI.
OrthoDBiPOG091H050Z.

Family and domain databases

Gene3Di3.10.180.10. 1 hit.
InterProiIPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR004360. Glyas_Fos-R_dOase_dom.
[Graphical view]
PfamiPF00903. Glyoxalase. 1 hit.
[Graphical view]
SUPFAMiSSF54593. SSF54593. 1 hit.

Sequencei

Sequence statusi: Complete.

Q98GG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEGLSHMTF IVRDLERMTR ILEGVFDARE VYASDTEQFS LSREKFFLIG
60 70 80 90 100
DIWVAIMQGE KLAERSYNHI AFKIDDADFD RYAERVGKLG LDMRPPRPRV
110 120 130
EGEGRSIYFY DDDNHMFELH TGTLTERLAR KAKGLEAAQ
Length:139
Mass (Da):16,181
Last modified:October 1, 2001 - v1
Checksum:i8F9138A570B900F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB50255.1.
RefSeqiWP_010911601.1. NC_002678.2.

Genome annotation databases

EnsemblBacteriaiBAB50255; BAB50255; BAB50255.
GeneIDi1227130.
KEGGimlo:mlr3345.
PATRICi22479521. VBIMesLot2464_2664.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB50255.1.
RefSeqiWP_010911601.1. NC_002678.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R9CX-ray1.83A/B1-139[»]
ProteinModelPortaliQ98GG1.
SMRiQ98GG1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266835.mlr3345.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB50255; BAB50255; BAB50255.
GeneIDi1227130.
KEGGimlo:mlr3345.
PATRICi22479521. VBIMesLot2464_2664.

Phylogenomic databases

eggNOGiENOG41081YN. Bacteria.
ENOG4111SM5. LUCA.
HOGENOMiHOG000232023.
OMAiNHIAFRI.
OrthoDBiPOG091H050Z.

Miscellaneous databases

EvolutionaryTraceiQ98GG1.

Family and domain databases

Gene3Di3.10.180.10. 1 hit.
InterProiIPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR004360. Glyas_Fos-R_dOase_dom.
[Graphical view]
PfamiPF00903. Glyoxalase. 1 hit.
[Graphical view]
SUPFAMiSSF54593. SSF54593. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFOSX_RHILO
AccessioniPrimary (citable) accession number: Q98GG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2001
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.