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Protein

Fosfomycin resistance protein FosX

Gene

fosX

Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the hydration of fosfomycin.1 Publication

Cofactori

Mn2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7Manganese1
Active sitei44Proton acceptorCurated1
Metal bindingi69Manganese1
Metal bindingi118Manganese1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAntibiotic resistance
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciMLOT266835:G1G20-2651-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Fosfomycin resistance protein FosX
Gene namesi
Name:fosX
Ordered Locus Names:mlr3345
OrganismiMesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi44E → G: Decrease in activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001640471 – 139Fosfomycin resistance protein FosXAdd BLAST139

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi266835.mlr3345

Structurei

Secondary structure

1139
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 13Combined sources12
Helixi15 – 26Combined sources12
Beta strandi29 – 33Combined sources5
Helixi34 – 36Combined sources3
Beta strandi44 – 49Combined sources6
Beta strandi52 – 58Combined sources7
Beta strandi69 – 73Combined sources5
Helixi76 – 78Combined sources3
Helixi79 – 89Combined sources11
Beta strandi106 – 110Combined sources5
Beta strandi116 – 120Combined sources5
Helixi124 – 129Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R9CX-ray1.83A/B1-139[»]
ProteinModelPortaliQ98GG1
SMRiQ98GG1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ98GG1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 122VOCPROSITE-ProRule annotationAdd BLAST119

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG41081YN Bacteria
ENOG4111SM5 LUCA
HOGENOMiHOG000232023
OMAiIPRNDIQ
OrthoDBiPOG091H050Z

Family and domain databases

CDDicd08364 FosX, 1 hit
Gene3Di3.10.180.10, 1 hit
InterProiView protein in InterPro
IPR037434 FosX
IPR029068 Glyas_Bleomycin-R_OHBP_Dase
IPR004360 Glyas_Fos-R_dOase_dom
IPR037523 VOC
PfamiView protein in Pfam
PF00903 Glyoxalase, 1 hit
SUPFAMiSSF54593 SSF54593, 1 hit
PROSITEiView protein in PROSITE
PS51819 VOC, 1 hit

Sequencei

Sequence statusi: Complete.

Q98GG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEGLSHMTF IVRDLERMTR ILEGVFDARE VYASDTEQFS LSREKFFLIG
60 70 80 90 100
DIWVAIMQGE KLAERSYNHI AFKIDDADFD RYAERVGKLG LDMRPPRPRV
110 120 130
EGEGRSIYFY DDDNHMFELH TGTLTERLAR KAKGLEAAQ
Length:139
Mass (Da):16,181
Last modified:October 1, 2001 - v1
Checksum:i8F9138A570B900F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB50255.1
RefSeqiWP_010911601.1, NC_002678.2

Genome annotation databases

EnsemblBacteriaiBAB50255; BAB50255; BAB50255
KEGGimlo:mlr3345
PATRICifig|266835.9.peg.2664

Similar proteinsi

Entry informationi

Entry nameiFOSX_RHILO
AccessioniPrimary (citable) accession number: Q98GG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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