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Protein

Homoserine O-acetyltransferase

Gene

metXA

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.UniRule annotation

Catalytic activityi

Acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine.UniRule annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Homoserine O-acetyltransferase (metXA)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei161NucleophileUniRule annotation1
Binding sitei231SubstrateUniRule annotation1
Active sitei327UniRule annotation1
Active sitei360UniRule annotation1
Binding sitei361SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAmino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00051; UER00074

Protein family/group databases

ESTHERimeslo-MLR3538 Homoserine_transacetylase

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine O-acetyltransferaseUniRule annotation (EC:2.3.1.31UniRule annotation)
Short name:
HATUniRule annotation
Alternative name(s):
Homoserine transacetylaseUniRule annotation
Short name:
HTAUniRule annotation
Gene namesi
Name:metXAUniRule annotation
Ordered Locus Names:mlr3538
OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001557411 – 389Homoserine O-acetyltransferaseAdd BLAST389

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi266835.mlr3538

Structurei

3D structure databases

ProteinModelPortaliQ98G09
SMRiQ98G09
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 366AB hydrolase-1UniRule annotationAdd BLAST311

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. MetX family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWV Bacteria
COG2021 LUCA
HOGENOMiHOG000246301
KOiK00641
OMAiCQGTTGP
OrthoDBiPOG091H08NY

Family and domain databases

Gene3Di3.40.50.18202 hits
HAMAPiMF_00296 MetX_acyltransf, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR008220 HAT_MetX-like
PANTHERiPTHR32268 PTHR32268, 1 hit
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PIRSFiPIRSF000443 Homoser_Ac_trans, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
TIGRFAMsiTIGR01392 homoserO_Ac_trn, 1 hit

Sequencei

Sequence statusi: Complete.

Q98G09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALRAGKTN NEADQPSSPV LRFGADKPLK LDAGTLLSPF QIAYQTYGTL
60 70 80 90 100
NDARSNAILV CHALTGDQHV ANTNPVTGKP GWWEVLIGPG RIIDTNRFFV
110 120 130 140 150
ICSNVIGGCL GSTGPASTNP ATGKPYGLDL PVITIRDMVR AQQMLIDHFG
160 170 180 190 200
IEKLFCVLGG SMGGMQVLEW ASSYPERVFS ALPIATGARH SSQNIAFHEV
210 220 230 240 250
GRQAVMADPD WHGGKYFENG KRPEKGLAVA RMAAHITYLS EAALHRKFGR
260 270 280 290 300
NLQDREALTF GFDADFQIES YLRHQGMTFV DRFDANSYLY MTRSMDYFDL
310 320 330 340 350
AADHGGRLAD AFAGTKTRFC LVSFTSDWLF PTEESRSIVH ALNAAGASVS
360 370 380
FVEIETDRGH DAFLLDEPEL FAAINGFIGS AARARGLSA
Length:389
Mass (Da):42,364
Last modified:October 1, 2001 - v1
Checksum:i0679C21C79C92CA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB50407.1
RefSeqiWP_010911753.1, NC_002678.2

Genome annotation databases

EnsemblBacteriaiBAB50407; BAB50407; BAB50407
KEGGimlo:mlr3538

Similar proteinsi

Entry informationi

Entry nameiMETXA_RHILO
AccessioniPrimary (citable) accession number: Q98G09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 1, 2001
Last modified: February 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome