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Protein

Shikimate kinase

Gene

aroK

Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.UniRule annotation

Catalytic activityi

ATP + shikimate = ADP + shikimate 3-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase (mll4988)
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroQ)
  4. Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK), Shikimate kinase (aroK), Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi36MagnesiumUniRule annotation1
Binding sitei54SubstrateUniRule annotation1
Binding sitei78SubstrateUniRule annotation1
Binding sitei100Substrate; via amide nitrogenUniRule annotation1
Binding sitei138ATPUniRule annotation1
Binding sitei157SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 37ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLOT266835:G1G20-2845-MONOMER
UniPathwayiUPA00053; UER00088

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate kinaseUniRule annotation (EC:2.7.1.71UniRule annotation)
Short name:
SKUniRule annotation
Gene namesi
Name:aroKUniRule annotation
Ordered Locus Names:mll3573
OrganismiMesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002379191 – 203Shikimate kinaseAdd BLAST203

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi266835.mll3573

Structurei

3D structure databases

ProteinModelPortaliQ98FY0
SMRiQ98FY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the shikimate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105KHV Bacteria
COG0703 LUCA
HOGENOMiHOG000032568
KOiK00891
OMAiHGEPHFR
OrthoDBiPOG091H02J5

Family and domain databases

CDDicd00464 SK, 1 hit
HAMAPiMF_00109 Shikimate_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR031322 Shikimate/glucono_kinase
IPR000623 Shikimate_kinase/TSH1
IPR023000 Shikimate_kinase_CS
PfamiView protein in Pfam
PF01202 SKI, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS01128 SHIKIMATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q98FY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAHQANPPG ESLAALLGRL GSRSIVFVGL MGAGKTAIGR KVATMLSLPF
60 70 80 90 100
IDSDQEIESV SRMTVPELFE RYGEAEFRAL EQRVILRVLE NGPQVLSTGG
110 120 130 140 150
GAFMNAQTRE AIAGHGVSVW LKAELDLLMD RVSKKQNRPL LKSADPRAVL
160 170 180 190 200
ERLMSERYPV YATSDVTVPT RDDRKEVIAA EVLNALCRHF GIDEIAATGE

IES
Length:203
Mass (Da):22,161
Last modified:October 1, 2001 - v1
Checksum:iBB875627EB2C464E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB50436.1
RefSeqiWP_010911782.1, NC_002678.2

Genome annotation databases

EnsemblBacteriaiBAB50436; BAB50436; BAB50436
KEGGimlo:mll3573
PATRICifig|266835.9.peg.2847

Similar proteinsi

Entry informationi

Entry nameiAROK_RHILO
AccessioniPrimary (citable) accession number: Q98FY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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