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Protein

Crossover junction endodeoxyribonuclease RuvC

Gene

ruvC

Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi11MagnesiumUniRule annotation1
Metal bindingi71MagnesiumUniRule annotation1
Metal bindingi143MagnesiumUniRule annotation1
Metal bindingi146MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Nuclease
Biological processDNA damage, DNA recombination, DNA repair
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciMLOT266835:G1G20-3107-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RuvCUniRule annotation (EC:3.1.22.4UniRule annotation)
Alternative name(s):
Holliday junction nuclease RuvCUniRule annotation
Holliday junction resolvase RuvCUniRule annotation
Gene namesi
Name:ruvCUniRule annotation
Ordered Locus Names:mll3901
OrganismiMesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001831251 – 169Crossover junction endodeoxyribonuclease RuvCAdd BLAST169

Interactioni

Protein-protein interaction databases

STRINGi266835.mll3901

Structurei

3D structure databases

ProteinModelPortaliQ98F72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105NHU Bacteria
COG0817 LUCA
HOGENOMiHOG000012181
KOiK01159
OMAiGLTRCGI
OrthoDBiPOG091H0202

Family and domain databases

Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00034 RuvC, 1 hit
InterProiView protein in InterPro
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR002176 X-over_junc_endoDNase_RuvC
PANTHERiPTHR30194 PTHR30194, 1 hit
PfamiView protein in Pfam
PF02075 RuvC, 1 hit
PRINTSiPR00696 RSOLVASERUVC
SUPFAMiSSF53098 SSF53098, 1 hit
TIGRFAMsiTIGR00228 ruvC, 1 hit

Sequencei

Sequence statusi: Complete.

Q98F72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDAIRIIGI DPGLRRTGWG IVESLGNSLR FVASGTVRSE DKAALATRLC
60 70 80 90 100
QLHDGLAEVL HAAMPHEAAV EQTFVNKDAV ATLKLGQARG IAMLVPARAG
110 120 130 140 150
LVVAEYAPNA VKKAVIGVGH GDKKQIHMMV KVLLPKATFD TEHAADALAI
160
AICHAHHRQS AAYRMALAG
Length:169
Mass (Da):17,840
Last modified:October 1, 2001 - v1
Checksum:i4C8D36002C8F1518
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB50695.1
RefSeqiWP_010912038.1, NC_002678.2

Genome annotation databases

EnsemblBacteriaiBAB50695; BAB50695; BAB50695
GeneIDi31697281
KEGGimlo:mll3901
PATRICifig|266835.9.peg.3105

Similar proteinsi

Entry informationi

Entry nameiRUVC_RHILO
AccessioniPrimary (citable) accession number: Q98F72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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