Q98F05 (ALR2_RHILO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alanine racemase, catabolic
EC=5.1.1.1

Gene names

Name:	dadB
Ordered Locus Names:	mll3997

Organism

Rhizobium loti (strain MAFF303099) (Mesorhizobium loti) [Complete proteome] [HAMAP]

Taxonomic identifier

266835 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Mesorhizobium

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Isomerizes L-alanine to D-alanine which is then oxidized to pyruvate by DadA By similarity. HAMAP MF_01201
Catalytic activity	L-alanine = D-alanine. HAMAP MF_01201
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01201
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP MF_01201
Induction	By alanine. HAMAP MF_01201
Sequence similarities	Belongs to the alanine racemase family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	alanine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	alanine racemase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 381	381	Alanine racemase, catabolic HAMAP MF_01201		PRO_0000114552
Sites
	Active site	55	1	Proton acceptor; specific for D-alanine By similarity
	Active site	276	1	Proton acceptor; specific for L-alanine By similarity
Amino acid modifications
	Modified residue	55	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q98F05 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 22B0C7837380066F	FASTA	381	39,784
	10 20 30 40 50 60 MNDAVNPTAA KTVTGWPVSE AAAGAILTID LGAIRENYRR LKALLGGVHC AGVVKANGYG 70 80 90 100 110 120 LGAAKVAAAL TREGCDIFFV ALLAEGIALR KAVGTGPDIY VLNGLPPGSE PEAVAAGLCA 130 140 150 160 170 180 VINSGAQLKA WRAAVHDAGR RLPAAIQVDS GMSRLGMAPA EVEALAGDSS AFDGIDIKYV 190 200 210 220 230 240 MSHLACADEP RHPANEQQRL AFERLRAMLP RAPASLANSS GIFLGPSYHH DLARPGAALY 250 260 270 280 290 300 GINPTPGEPN PMLPVVWLQA KVAQTRRIEK GAGIGYGHSY HADGPLSLAT ISFGYADGWL 310 320 330 340 350 360 RRSASAAWFE GVRLPFLGRV SMDSIILDIS ALPPGRLREG DLVELLGPSQ SVDDAAGHAG 370 380 TIGYEILASL GPRFHRHYVG G

References

[1]

"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti." Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S. DNA Res. 7:331-338(2000) [PubMed: 11214968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MAFF303099.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000012 Genomic DNA. Translation: BAB50762.1.
RefSeq	NP_104976.1. NC_002678.2.
3D structure databases
ProteinModelPortal	Q98F05.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1227637.
GenomeReviews	Gene locus mll3997 in contig BA000012_GR.
KEGG	mlo:mll3997.
NMPDR	fig|266835.1.peg.3080.
PATRIC	22480569. VBIMesLot2464_3173.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG712172.
OMA	ILFIMSH.
Family and domain databases
HAMAP	MF_01201. Ala_racemase. [Tree]
InterPro	IPR000821. Ala_racemase. IPR009006. Ala_racemase/Decarboxylase_C. IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR020622. Ala_racemase_pyridoxalP-BS. [Graphical view]
Gene3D	G3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 1 hit.
KO	K01775.
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
SMART	SM01005. Ala_racemase_C. 1 hit. [Graphical view]
SUPFAM	SSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMs	TIGR00492. Alr. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALR2_RHILO

Accession

Primary (citable) accession number: Q98F05

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	October 1, 2001
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program