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Q98EU7

- SYL_RHILO

UniProt

Q98EU7 - SYL_RHILO

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei634 – 6341ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMLOT266835:GJ9L-3177-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:mll4077
    OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
    Taxonomic identifieri266835 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
    ProteomesiUP000000552: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 875875Leucine--tRNA ligasePRO_0000152070Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266835.mll4077.

    Structurei

    3D structure databases

    ProteinModelPortaliQ98EU7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5311"HIGH" regionAdd
    BLAST
    Motifi631 – 6355"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHELEVYT.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q98EU7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATERYNPRA SEPKWQKAWA EKKLFEARND DPKPKYYVLE MFPYPSGRIH    50
    IGHTRNYTMG DVVARYKRAK GFNVLHPMGW DAFGMPAENA AMQNKVHPKE 100
    WTYQNIATMR EQLKVMGLSL DWAREFATCD VDYYHRQQML FLDFVEKGLV 150
    TRKSSKVNWD PEDMTVLANE QVIDGRGWRS GALVEQRELT QWFFKITDFA 200
    QDLLDSLEGL DEWPEKVKLM QQNWIGRSEG LLIRWPLASD VAGEHELEVY 250
    TTRPDTIFGA SFMAVAADHP LAKKAAETNP ALAKFIDEVR HMGTSVAALE 300
    TAEKKGFDTG IRVVHPFDDS WTLPVYVANF VLMEYGTGAI FGCPSGDQRD 350
    LDFANKYGLP VIPVVMPEGG DAKSFQITEE AYVDDGVMIN SRFLDGMKPD 400
    RAFDEVAKLL EQKTIGNRPM AERKVNFRLR DWGISRQRYW GCPIPMIHCE 450
    DCGVVPVPKA DLPVKLPDDV DFDRPGNPLD RHPTWRHVKC PQCGRDARRE 500
    TDTMDTFVDS SWYFARFTAP WAYEPTDPRA ANEWLPVDQY IGGIEHAILH 550
    LLYSRFFTRA MRATGHVDLA EPFKGLFTQG MVVHETYRVG GASNNGRWLS 600
    PAEVRIEDAE GKRRAIEIAT GEEAAIGSLE KMSKSKKNTV SPEDITDGYG 650
    ADTARWLMLS DSPPEGDVEW TDDGAAGAHR FMQRIWRLVS TAAETLAGVK 700
    PAAADSGEAG AVRKATHKIL KAVGEDIEKL GFNRAIARIY ELANVLTTPL 750
    NQVAEGKADP ALQGACREAV EILVHLIAPV MPHLAEECWE TLGGTDLVAE 800
    RPWPAFDPAL VVDNEVTYPV QVNGKKRGDL TIARDADQGA VEKAVLALDF 850
    VQKALEGKAP RKVIIVPQRI VNVVA 875
    Length:875
    Mass (Da):98,134
    Last modified:October 1, 2001 - v1
    Checksum:i3A2F64BC5199FF20
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB50820.1.
    RefSeqiNP_105034.1. NC_002678.2.
    WP_010912163.1. NC_002678.2.

    Genome annotation databases

    EnsemblBacteriaiBAB50820; BAB50820; BAB50820.
    GeneIDi1227695.
    KEGGimlo:mll4077.
    PATRICi22480675. VBIMesLot2464_3225.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB50820.1 .
    RefSeqi NP_105034.1. NC_002678.2.
    WP_010912163.1. NC_002678.2.

    3D structure databases

    ProteinModelPortali Q98EU7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266835.mll4077.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB50820 ; BAB50820 ; BAB50820 .
    GeneIDi 1227695.
    KEGGi mlo:mll4077.
    PATRICi 22480675. VBIMesLot2464_3225.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HELEVYT.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci MLOT266835:GJ9L-3177-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MAFF303099.

    Entry informationi

    Entry nameiSYL_RHILO
    AccessioniPrimary (citable) accession number: Q98EU7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2003
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3