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Q98EU7

- SYL_RHILO

UniProt

Q98EU7 - SYL_RHILO

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Protein

Leucine--tRNA ligase

Gene
leuS, mll4077
Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei634 – 6341ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLOT266835:GJ9L-3177-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:mll4077
OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
ProteomesiUP000000552: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 875875Leucine--tRNA ligaseUniRule annotationPRO_0000152070Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266835.mll4077.

Structurei

3D structure databases

ProteinModelPortaliQ98EU7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionUniRule annotationAdd
BLAST
Motifi631 – 6355"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHELEVYT.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q98EU7-1 [UniParc]FASTAAdd to Basket

« Hide

MATERYNPRA SEPKWQKAWA EKKLFEARND DPKPKYYVLE MFPYPSGRIH    50
IGHTRNYTMG DVVARYKRAK GFNVLHPMGW DAFGMPAENA AMQNKVHPKE 100
WTYQNIATMR EQLKVMGLSL DWAREFATCD VDYYHRQQML FLDFVEKGLV 150
TRKSSKVNWD PEDMTVLANE QVIDGRGWRS GALVEQRELT QWFFKITDFA 200
QDLLDSLEGL DEWPEKVKLM QQNWIGRSEG LLIRWPLASD VAGEHELEVY 250
TTRPDTIFGA SFMAVAADHP LAKKAAETNP ALAKFIDEVR HMGTSVAALE 300
TAEKKGFDTG IRVVHPFDDS WTLPVYVANF VLMEYGTGAI FGCPSGDQRD 350
LDFANKYGLP VIPVVMPEGG DAKSFQITEE AYVDDGVMIN SRFLDGMKPD 400
RAFDEVAKLL EQKTIGNRPM AERKVNFRLR DWGISRQRYW GCPIPMIHCE 450
DCGVVPVPKA DLPVKLPDDV DFDRPGNPLD RHPTWRHVKC PQCGRDARRE 500
TDTMDTFVDS SWYFARFTAP WAYEPTDPRA ANEWLPVDQY IGGIEHAILH 550
LLYSRFFTRA MRATGHVDLA EPFKGLFTQG MVVHETYRVG GASNNGRWLS 600
PAEVRIEDAE GKRRAIEIAT GEEAAIGSLE KMSKSKKNTV SPEDITDGYG 650
ADTARWLMLS DSPPEGDVEW TDDGAAGAHR FMQRIWRLVS TAAETLAGVK 700
PAAADSGEAG AVRKATHKIL KAVGEDIEKL GFNRAIARIY ELANVLTTPL 750
NQVAEGKADP ALQGACREAV EILVHLIAPV MPHLAEECWE TLGGTDLVAE 800
RPWPAFDPAL VVDNEVTYPV QVNGKKRGDL TIARDADQGA VEKAVLALDF 850
VQKALEGKAP RKVIIVPQRI VNVVA 875
Length:875
Mass (Da):98,134
Last modified:October 1, 2001 - v1
Checksum:i3A2F64BC5199FF20
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000012 Genomic DNA. Translation: BAB50820.1.
RefSeqiNP_105034.1. NC_002678.2.
WP_010912163.1. NC_002678.2.

Genome annotation databases

EnsemblBacteriaiBAB50820; BAB50820; BAB50820.
GeneIDi1227695.
KEGGimlo:mll4077.
PATRICi22480675. VBIMesLot2464_3225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000012 Genomic DNA. Translation: BAB50820.1 .
RefSeqi NP_105034.1. NC_002678.2.
WP_010912163.1. NC_002678.2.

3D structure databases

ProteinModelPortali Q98EU7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266835.mll4077.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB50820 ; BAB50820 ; BAB50820 .
GeneIDi 1227695.
KEGGi mlo:mll4077.
PATRICi 22480675. VBIMesLot2464_3225.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HELEVYT.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci MLOT266835:GJ9L-3177-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MAFF303099.

Entry informationi

Entry nameiSYL_RHILO
AccessioniPrimary (citable) accession number: Q98EU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: October 1, 2001
Last modified: September 3, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi