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Q98ES7

- PUR9_RHILO

UniProt

Q98ES7 - PUR9_RHILO

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciMLOT266835:GJ9L-3197-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:mlr4101
OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
ProteomesiUP000000552: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538Bifunctional purine biosynthesis protein PurHPRO_0000192116Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266835.mlr4101.

Structurei

3D structure databases

ProteinModelPortaliQ98ES7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OMAiCGVATGP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q98ES7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVAAKNIPA PDLVPVRRAL LSVFDKTGLI DFARALAAAG VELVSTGGTA
60 70 80 90 100
KAIAEAGLAV RDVSELTGFP EIMDGRVKTL HPSVHGALLG VRDDPEHAAA
110 120 130 140 150
MRKYGIEPID LLVSNLYPFE EVRRSGADYA AIVENIDIGG PAMIRASAKN
160 170 180 190 200
HAYVAIVTDP GDYASVLNAL EMNIGSLSLD FRKKLAAKAF ARTATYDAAI
210 220 230 240 250
SGWFAEALEI EHPTWRAFGG RLTEVMRYGE NPHQSAGFYV NGDKRPGVAT
260 270 280 290 300
ARQLQGKQLS YNNINDTDAA FELAGEFDPS RSAAVAIIKH ANPCGVAEGT
310 320 330 340 350
SLKSAYAKAL ACDPVSAFGG IVAVNRTLDA EAAEDIVKTF TEVIIAPDAT
360 370 380 390 400
DEAAAIVAAK KNLRLLVTGG LPDPRSPGTT VKSVAGGLLV QGRDNAVVDD
410 420 430 440 450
LELKVVTKRA PTPAEMADLK FAFRVAKHVK SNAIVYAKDG ATVGIGAGQM
460 470 480 490 500
SRVDSSRIAA RKALDAAEAA GMTEPLTTGS VVASDAFFPF ADGLLAAVAA
510 520 530
GATAVIQPGG SMNDKDVIAA ADEHGIAMVF TGVRHFRH
Length:538
Mass (Da):56,197
Last modified:October 1, 2001 - v1
Checksum:i99A385431FB05517
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000012 Genomic DNA. Translation: BAB50840.1.
RefSeqiNP_105054.1. NC_002678.2.

Genome annotation databases

EnsemblBacteriaiBAB50840; BAB50840; BAB50840.
GeneIDi1227715.
KEGGimlo:mlr4101.
PATRICi22480713. VBIMesLot2464_3244.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000012 Genomic DNA. Translation: BAB50840.1 .
RefSeqi NP_105054.1. NC_002678.2.

3D structure databases

ProteinModelPortali Q98ES7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266835.mlr4101.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB50840 ; BAB50840 ; BAB50840 .
GeneIDi 1227715.
KEGGi mlo:mlr4101.
PATRICi 22480713. VBIMesLot2464_3244.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OMAi CGVATGP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci MLOT266835:GJ9L-3197-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MAFF303099.

Entry informationi

Entry nameiPUR9_RHILO
AccessioniPrimary (citable) accession number: Q98ES7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: October 1, 2001
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3