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Protein

DNA translocase FtsK

Gene

ftsK

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi535 – 5406ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLOT266835:GJ9L-3304-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA translocase FtsK
Gene namesi
Name:ftsK
Ordered Locus Names:mll4243
OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5021HelicalSequence analysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence analysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence analysisAdd
BLAST
Transmembranei141 – 16121HelicalSequence analysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence analysisAdd
BLAST
Topological domaini185 – 887703CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 887887DNA translocase FtsKPRO_0000098284Add
BLAST

Interactioni

Subunit structurei

Homohexamer. Forms a ring that surrounds DNA (By similarity).By similarity

Protein-protein interaction databases

STRINGi266835.mll4243.

Structurei

3D structure databases

ProteinModelPortaliQ98EH3.
SMRiQ98EH3. Positions 380-793.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini515 – 734220FtsKPROSITE-ProRule annotationAdd
BLAST

Domaini

Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase (By similarity).By similarity

Sequence similaritiesi

Belongs to the FtsK/SpoIIIE/SftA family.Curated
Contains 1 FtsK domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CNU. Bacteria.
COG1674. LUCA.
HOGENOMiHOG000010003.
KOiK03466.
OMAiQECRLIM.
OrthoDBiPOG091H01S4.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR025199. FtsK_4TM.
IPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF13491. FtsK_4TM. 1 hit.
PF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00843. Ftsk_gamma. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50901. FTSK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q98EH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSGASAPLA MTDTGHGIQA FARRQVGRLV GAGMFLAVAF GVASLATWNV
60 70 80 90 100
ADPSFSHATN NTVTNAMGYA GAVFSDLAMQ FFGLAAVAAL VPAVIWGYLL
110 120 130 140 150
FSARGVDRLP KRGLFWFGFA LLAAAIAGCI VPPKTWPLPT GLGGVFGDMV
160 170 180 190 200
LKIPGVLIGG YPTGLIASVL AVLLAGPTLW LFAFGSALIG RKNGFAVMEE
210 220 230 240 250
PAAADPREDD LLFDNEEDEG DEGILALGAI THWWLSLRAW MHRRAVRRRQ
260 270 280 290 300
ERDEYEPEME PRASAWRRAA ERVESAEFAE QRMSPGGRAR VEPEFFAAMV
310 320 330 340 350
NDRSVSVDPD DDDIFDRDDE DMDFDDEPVA QRRAAPAAKV QQFRSDAATR
360 370 380 390 400
VEAPAPRPAP GARVQREAQT SLIGSDKFEM PSLHFLSEPK NVARDPSLSK
410 420 430 440 450
DALEQNARLL EGVLEDFGVK GEIIAVRPGP VVTLYELEPA PGIKSSRVIG
460 470 480 490 500
LSDDIARSMS AIACRVAVVP GRNAIGIELP NAKRETVYLR EIMASRDFET
510 520 530 540 550
TKAKLALALG KTINGEAVIV DIAKMPHVLV AGTTGSGKSV AINTMILSLL
560 570 580 590 600
YRLTPQECRL IMIDPKMLEL SVYDGIPHLL TPVVTDPKKA VVALKWTVRE
610 620 630 640 650
MEDRYRKMSK VGVRNIDGFN ARVQLAEKKG EKISRTVQTG FDRQTGEAIY
660 670 680 690 700
ETEDLDLEPM PYIVVIIDEM ADLMMVAGKD IEGAVQRLAQ MARAAGIHVI
710 720 730 740 750
MATQRPSVDV ITGTIKANFP TRISFQVTSK IDSRTILGEQ GAEQLLGMGD
760 770 780 790 800
MLYMAGGGRI QRVHGPFVSD DEVEKIVGHL KLQGVPEYLD AITEDDDEDD
810 820 830 840 850
DEPSGKGAGS GGGGGGNFED SDDPYDQAVA VVLRDGKAST SYIQRRLGIG
860 870 880
YNRAASIIEK MEKEGIVGPA NHAGKREILV PTEDDKF
Length:887
Mass (Da):96,130
Last modified:October 1, 2001 - v1
Checksum:i9AC9AA38D13CA863
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB50946.1.
RefSeqiWP_010912288.1. NC_002678.2.

Genome annotation databases

EnsemblBacteriaiBAB50946; BAB50946; BAB50946.
GeneIDi1227821.
KEGGimlo:mll4243.
PATRICi22480923. VBIMesLot2464_3348.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB50946.1.
RefSeqiWP_010912288.1. NC_002678.2.

3D structure databases

ProteinModelPortaliQ98EH3.
SMRiQ98EH3. Positions 380-793.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266835.mll4243.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB50946; BAB50946; BAB50946.
GeneIDi1227821.
KEGGimlo:mll4243.
PATRICi22480923. VBIMesLot2464_3348.

Phylogenomic databases

eggNOGiENOG4105CNU. Bacteria.
COG1674. LUCA.
HOGENOMiHOG000010003.
KOiK03466.
OMAiQECRLIM.
OrthoDBiPOG091H01S4.

Enzyme and pathway databases

BioCyciMLOT266835:GJ9L-3304-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR025199. FtsK_4TM.
IPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF13491. FtsK_4TM. 1 hit.
PF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00843. Ftsk_gamma. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50901. FTSK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFTSK_RHILO
AccessioniPrimary (citable) accession number: Q98EH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: October 1, 2001
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.