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Protein

Succinate--CoA ligase [ADP-forming] subunit alpha

Gene

mll4303

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei257 – 2571Tele-phosphohistidine intermediateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLOT266835:GJ9L-3350-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate--CoA ligase [ADP-forming] subunit alphaUniRule annotation (EC:6.2.1.5UniRule annotation)
Gene namesi
Ordered Locus Names:mll4303Imported
OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)Imported
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits.UniRule annotation

Protein-protein interaction databases

STRINGi266835.mll4303.

Structurei

3D structure databases

ProteinModelPortaliQ98EC8.
SMRiQ98EC8. Positions 2-299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 106103CoA_bindingInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the succinate/malate CoA ligase alpha subunit family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CH8. Bacteria.
COG0074. LUCA.
HOGENOMiHOG000239685.
KOiK01902.
OMAiVYSDTRN.
OrthoDBiPOG091H04FK.

Family and domain databases

Gene3Di3.40.50.261. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
PfamiPF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFiPIRSF001553. SucCS_alpha. 1 hit.
PRINTSiPR01798. SCOASYNTHASE.
SMARTiSM00881. CoA_binding. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF52210. SSF52210. 1 hit.
TIGRFAMsiTIGR01019. sucCoAalpha. 1 hit.
PROSITEiPS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q98EC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILVDKNTK VLVQGLTGKT GTFHTEQALA YHGTKMVGGI HPKKGGETWT
60 70 80 90 100
GSKGESLPIF ATVAEGKAKT GANASVVYVP PAGAAEAILE AIEAEIPLII
110 120 130 140 150
CITEGIPVMD MVKVKARLDR STSRLIGPNC PGVLTPDECK IGIMPGNIFR
160 170 180 190 200
KGSVGVVSRS GTLTYEAVFQ TTNVGLGQTT AVGIGGDPVK GTEFIDVLEM
210 220 230 240 250
FLADDETKSI IMIGEIGGSA EEDAAQFLKD EAKRGRKKPM AGFIAGRTAP
260 270 280 290 300
AGRTMGHAGA VISGGKGGAE DKIAAMESAG IKVSPSPARL GTTLVEAIKG
Length:300
Mass (Da):30,862
Last modified:October 1, 2001 - v1
Checksum:i6FD24A5A474CE034
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB50992.1.
RefSeqiWP_010912334.1. NC_002678.2.

Genome annotation databases

EnsemblBacteriaiBAB50992; BAB50992; BAB50992.
GeneIDi1227867.
KEGGimlo:mll4303.
PATRICi22481019. VBIMesLot2464_3396.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB50992.1.
RefSeqiWP_010912334.1. NC_002678.2.

3D structure databases

ProteinModelPortaliQ98EC8.
SMRiQ98EC8. Positions 2-299.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266835.mll4303.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB50992; BAB50992; BAB50992.
GeneIDi1227867.
KEGGimlo:mll4303.
PATRICi22481019. VBIMesLot2464_3396.

Phylogenomic databases

eggNOGiENOG4105CH8. Bacteria.
COG0074. LUCA.
HOGENOMiHOG000239685.
KOiK01902.
OMAiVYSDTRN.
OrthoDBiPOG091H04FK.

Enzyme and pathway databases

BioCyciMLOT266835:GJ9L-3350-MONOMER.

Family and domain databases

Gene3Di3.40.50.261. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
PfamiPF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFiPIRSF001553. SucCS_alpha. 1 hit.
PRINTSiPR01798. SCOASYNTHASE.
SMARTiSM00881. CoA_binding. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF52210. SSF52210. 1 hit.
TIGRFAMsiTIGR01019. sucCoAalpha. 1 hit.
PROSITEiPS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ98EC8_RHILO
AccessioniPrimary (citable) accession number: Q98EC8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2001
Last sequence update: October 1, 2001
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.