Reviewed, UniProtKB/Swiss-Prot Q98DV6 (MSRA2_RHILO)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrA 2
      Short name=Protein-methionine-S-oxide reductase 2
    EC=1.8.4.11
Alternative name(s):
    Peptide-methionine (S)-S-oxide reductase 2
      Short name=Peptide Met(O) reductase 2

Gene names

Name:	msrA2
Ordered Locus Names:	mll4530

Organism

Rhizobium loti (Mesorhizobium loti) [Complete proteome] [HAMAP]

Taxonomic identifier

381 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Mesorhizobium

Protein attributes

Sequence length	195 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity.
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the msrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 195	195	Peptide methionine sulfoxide reductase msrA 2 HAMAP MF_01401		PRO_0000138572
Sites
	Active site	18	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q98DV6-1 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 9E1BAD9D7A4A2638	FASTA	195	21,351
	10 20 30 40 50 60 MDEKAAPGSE TAIFAGGCFW GVQGVFQHVK GVSKAVSGYT GGAKDDAVYE TVGTGRTGHA 70 80 90 100 110 120 ESVEITYDPS KVTYGQLLQV YFSVAHNPTQ LNFQGPDSGT QYRSTIFAEN DTQKQIAQSY 130 140 150 160 170 180 IDQLDKAKLY PAPIVTTIET GKTFYPAENY HQDFLTLNPT YPYIVYNDLP KVANLKQLFP 190 ALYSEKPVLV LSASN

References

[1]

"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti." Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S. DNA Res. 7:331-338(2000) [PubMed: 11214968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MAFF303099.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000012 Genomic DNA. Translation: BAB51164.1.
RefSeq	NP_105378.1.
3D structure databases
HSSP	HSSP built from PDB template 1FF3 based on UniProtKB P27110.
ModBase	Search...
Genome annotation databases
GeneID	1228039.
GenomeReviews	Gene locus mll4530 in contig BA000012_GR.
KEGG	mlo:mll4530.
NMPDR	fig|266835.1.peg.3482.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q98DV6.
OMA	Q98DV6. GQLLQVY.
Enzyme and pathway databases
BRENDA	1.8.4.11. 3315.
Family and domain databases
HAMAP	MF_01401. [Tree]
InterPro	IPR002569. MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
ProDom	PD003489. PMSR. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00401. msrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA2_RHILO

Accession

Primary (citable) accession number: Q98DV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	October 1, 2001
Last modified:	June 16, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)