Reviewed, UniProtKB/Swiss-Prot Q98DM7 (UPPP1_RHILO)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 1
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 1
    Bacitracin resistance protein 1

Gene names

Name:	uppP1
Synonyms:	bacA1, upk1
Ordered Locus Names:	mll4634

Organism

Rhizobium loti (Mesorhizobium loti) [Complete proteome] [HAMAP]

Taxonomic identifier

381 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Mesorhizobium

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Undecaprenyl-diphosphatase 1 HAMAP MF_01006		PRO_0000151185
Regions
	Transmembrane	5 – 25	21	Potential
	Transmembrane	43 – 63	21	Potential
	Transmembrane	81 – 101	21	Potential
	Transmembrane	107 – 127	21	Potential
	Transmembrane	185 – 205	21	Potential
	Transmembrane	214 – 234	21	Potential
	Transmembrane	248 – 268	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q98DM7-1 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 91EAEDEB3EA2E2C6	FASTA	268	29,529
	10 20 30 40 50 60 MESQTIVEAL LLGLLEGLTE FIPVSSTGHI LLAGHFLGFN STGKAFEILI QLGAILAILS 70 80 90 100 110 120 VYFRRLWQML LDLPHDRLTR HFVIGILIAF LPAAIIGALA HDFIKTVLFE SPRLICTMLI 130 140 150 160 170 180 IGGVILLAVD RMNLKPVYRD VERFPTRLYL QIGLFQCLSL IPGTSRSGST IVGALLLGVD 190 200 210 220 230 240 KRAAAEFSFF LAIPTMVGAF AFDLFKNRNV LTSADLPIIA IGFVAAFVTA LFVVRYLLDY 250 260 VSRNGYSLFG WWRLVVGIVG LVALMIWG

References

[1]

"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti." Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S. DNA Res. 7:331-338(2000) [PubMed: 11214968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MAFF303099.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000012 Genomic DNA. Translation: BAB51243.1.
RefSeq	NP_105457.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1228118.
GenomeReviews	Gene locus mll4634 in contig BA000012_GR.
KEGG	mlo:mll4634.
NMPDR	fig|266835.1.peg.3561.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q98DM7.
OMA	EERATAH.
Enzyme and pathway databases
BRENDA	3.6.1.27. 3315.
Family and domain databases
HAMAP	MF_01006. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP1_RHILO

Accession

Primary (citable) accession number: Q98DM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	October 1, 2001
Last modified:	November 3, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)