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Reviewed, UniProtKB/Swiss-Prot Q98D72 (PH4H_RHILO)

Last modified February 9, 2010. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Phenylalanine-4-hydroxylase
      Short name=PAH
    EC=1.14.16.1
Alternative name(s):
    Phe-4-monooxygenase
Gene names
Name: phhA
Ordered Locus Names: mlr4831
OrganismRhizobium loti (Mesorhizobium loti) [Complete proteome] [HAMAP]
Taxonomic identifier381 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4a-hydroxytetrahydrobiopterin.

Cofactor

Binds 1 Fe2+ ion By similarity.

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6.

Sequence similarities

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 275275Phenylalanine-4-hydroxylase
PRO_0000205557

Sites

Metal binding1351Iron Potential
Metal binding1401Iron Potential
Metal binding1811Iron Potential

Sequences

Sequence LengthMass (Da)Tools
Q98D72-1 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: BC29D255534BC215

FASTA27531,348
        10         20         30         40         50         60 
MSVAEYARDC AAQGLRGDYS VCRADFTVAQ DYDYSDEEQA VWRTLCDRQT KLTRKLAHHS 

        70         80         90        100        110        120 
YLDGVEKLGL LDRIPDFEDV STKLRKLTGW EIIAVPGLIP AAPFFDHLAN RRFPVTNWLR 

       130        140        150        160        170        180 
TRQELDYIVE PDMFHDFFGH VPVLSQPVFA DFMQMYGKKA GDIIALGGDE MITRLYWYTA 

       190        200        210        220        230        240 
EYGLVQEAGQ PLKAFGAGLM SSFTELQFAV EGKDAHHVPF DLETVMRTGY EIDKFQRAYF 

       250        260        270 
VLPSFDALRD AFQTADFEAI VARRKDQKAL DPATV 

« Hide

References

[1]"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti."
Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. expand/collapse author list , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S.
DNA Res. 7:331-338(2000) [PubMed: 11214968] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MAFF303099.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000012 Genomic DNA. Translation: BAB51399.1.
RefSeqNP_105613.1.

3D structure databases

SMRQ98D72. Positions 23-275.
ModBaseSearch...

Genome annotation databases

GeneID1228274.
GenomeReviewsGene locus mlr4831 in contig BA000012_GR.
KEGGmlo:mlr4831.
NMPDRfig|266835.1.peg.3717.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG403840.
OMAYKIDSYQ.

Enzyme and pathway databases

BRENDA1.14.16.1. 3315.

Family and domain databases

InterProIPR001273. ArAA_hydroxylase.
IPR018301. ArAA_hydroxylase_Fe/CU_BS.
IPR019774. Aromatic-AA_hydroxylase_C.
IPR005960. Phe-4-hydroxylase_mono.
[Graphical view]
Gene3DG3DSA:1.10.800.10. Aaa_hydroxylase. 1 hit.
PANTHERPTHR11473. Aaa_hydroxylase. 1 hit.
PfamPF00351. Biopterin_H. 1 hit.
[Graphical view]
PRINTSPR00372. FYWHYDRXLASE.
TIGRFAMsTIGR01267. Phe4hydrox_mono. 1 hit.
PROSITEPS00367. BIOPTERIN_HYDROXYL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePH4H_RHILO
AccessionPrimary (citable) accession number: Q98D72
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: October 1, 2001
Last modified: February 9, 2010
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents