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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciMLOT266835:G1G20-3846-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:mll4854
OrganismiMesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000830211 – 317Methionyl-tRNA formyltransferaseAdd BLAST317

Proteomic databases

PRIDEiQ98D53

Interactioni

Protein-protein interaction databases

STRINGi266835.mll4854

Structurei

3D structure databases

ProteinModelPortaliQ98D53
SMRiQ98D53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni112 – 115Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

Q98D53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLRVIFMGT PEFSVPTLRA IAKAGHEISA VYTQPPRAAG RRGLELTPSP
60 70 80 90 100
VQREAERLGI EVRTPTSLKG EAEQAAFNAL RADIAVVVAY GLLLPKVILD
110 120 130 140 150
APRLGCINGH ASLLPRWRGA APIQRAIMAG DLESGMMVMR MEEGLDTGPV
160 170 180 190 200
GLLEKCAIDP DMTAGDLHDR LMRVGAALMV EALARLAKNT LTFTAQAAEG
210 220 230 240 250
VTYARKIDKS ETRVDWTRPA AEVHNHLRGL SPFPGAWSEI DIGGRMERLK
260 270 280 290 300
LLRSTLSDGL SPSEDLGESG GILDDRLTVA CGAGAIRLVE VQRAGGKPAA
310
ASEFLRGAKI VKGMKFS
Length:317
Mass (Da):33,903
Last modified:October 1, 2001 - v1
Checksum:i47A099815954E92C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB51418.1
RefSeqiWP_010912759.1, NC_002678.2

Genome annotation databases

EnsemblBacteriaiBAB51418; BAB51418; BAB51418
KEGGimlo:mll4854
PATRICifig|266835.9.peg.3835

Similar proteinsi

Entry informationi

Entry nameiFMT_RHILO
AccessioniPrimary (citable) accession number: Q98D53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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