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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciMLOT266835:G1G20-3875-MONOMER
UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:mll4892
OrganismiMesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002058411 – 434Nicotinate phosphoribosyltransferaseAdd BLAST434

Interactioni

Protein-protein interaction databases

STRINGi266835.mll4892

Structurei

3D structure databases

ProteinModelPortaliQ98D24
SMRiQ98D24
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RH7 Bacteria
COG1488 LUCA
HOGENOMiHOG000284929
KOiK00763
OMAiKLTMQCA
OrthoDBiPOG091H0197

Family and domain databases

CDDicd01401 PncB_like, 1 hit
HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

Q98D24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARTDIARRV YNHTWKLDPI VRSLLDTDFY KLLMLQMIWG MYPKVDATFS
60 70 80 90 100
LINRTTSVRL ADEIDEGELR EQLDHARTLR FSKKEMIWLG GNNFYGRKQI
110 120 130 140 150
FEPEFLAWLE GFRLPDYELS KRDGQYELSF SGPWMYTTLW EIPALAIINE
160 170 180 190 200
LRSRAAMRAF GPFALDVLYA RAKAKMWAKT ERLKALPGIR ISDFGTRRRH
210 220 230 240 250
SFLWQRWCVE ALKEGIGEAF TGTSNVLLAM DNDLEALGTN AHELPMVFAA
260 270 280 290 300
LANSEKELKQ APYKVLQDWQ RYYGGNLLIV LPDAFGTASF LRDAPDWVAD
310 320 330 340 350
WTGFRPDSAP PIEGGEKILS WWRERGKDPK QKLLIFSDGL EVETIEETYR
360 370 380 390 400
HFKGKVRMSF GWGTNLTNDF EGCAPTETNS LDAISLVCKV TEANGRPAVK
410 420 430
LSDNPAKATG DEKEIERYLR IFGEKDRVEQ LVKV
Length:434
Mass (Da):49,889
Last modified:October 1, 2001 - v1
Checksum:iEBA1579A9094430F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB51447.1
RefSeqiWP_010912788.1, NC_002678.2

Genome annotation databases

EnsemblBacteriaiBAB51447; BAB51447; BAB51447
KEGGimlo:mll4892
PATRICifig|266835.9.peg.3866

Entry informationi

Entry nameiPNCB_RHILO
AccessioniPrimary (citable) accession number: Q98D24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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