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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei137L-tryptophanUniRule annotation1
Binding sitei208ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 15ATPUniRule annotation3
Nucleotide bindingi21 – 22ATPUniRule annotation2
Nucleotide bindingi149 – 151ATPUniRule annotation3
Nucleotide bindingi217 – 221ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLOT266835:G1G20-4217-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:mll5317
OrganismiMesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366661 – 355Tryptophan--tRNA ligaseAdd BLAST355

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi266835.mll5317

Structurei

3D structure databases

ProteinModelPortaliQ98C31
SMRiQ98C31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi14 – 22"HIGH" regionUniRule annotation9
Motifi217 – 221"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
HOGENOMiHOG000059940
KOiK01867
OMAiQRMTQFK
OrthoDBiPOG091H00I9

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 3 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q98C31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAFKPLVFS GVQPTGNLHL GNYLGAIKKF VALQETSDCI YCVVDLHSLT
60 70 80 90 100
AQLVHEDLAD QTRSITAAFL ASGIDPKKHI VFNQSRVMQH AELAWIFNCV
110 120 130 140 150
ARIGWMNKMT QFKDKAGKDR ENASLGLLAY PSLMAADILL YRATHVPVGE
160 170 180 190 200
DQKQHLELTR DIAQKFNNDF SDRIARLGVG VEMQVGEETV NGFFPITEPV
210 220 230 240 250
IGGPAARIMS LRDGSKKMSK SDPSDLSRIN LTDDADTISK KIRKAKTDPE
260 270 280 290 300
ALPSEVSGLE SRPEAENLVG IYAGLAEMSK ADVLKEFGGQ QFSVFKPALA
310 320 330 340 350
DLAVEKLAPI AGEMRRIEGD RAYVDAVLRD GGERAGVLAE TTMKTVRDII

GLLQG
Length:355
Mass (Da):38,760
Last modified:October 1, 2001 - v1
Checksum:iAA8CD99496A7CB7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB51790.1
RefSeqiWP_010913129.1, NC_002678.2

Genome annotation databases

EnsemblBacteriaiBAB51790; BAB51790; BAB51790
KEGGimlo:mll5317
PATRICifig|266835.9.peg.4216

Similar proteinsi

Entry informationi

Entry nameiSYW_RHILO
AccessioniPrimary (citable) accession number: Q98C31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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