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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei350 – 3501Proton donorBy similarity
Active sitei381 – 3811By similarity
Active sitei510 – 5101By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciMLOT266835:GJ9L-4230-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:mlr5411
OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
ProteomesiUP000000552 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 547547Glucose-6-phosphate isomerasePRO_0000180718Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266835.mlr5411.

Structurei

3D structure databases

SMRiQ98BV5. Positions 12-546.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiFELANDC.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q98BV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKSAFQKQL AALRDHRSAA PASMRQAFAA DPQRFQAFTA TDGDLLLDWS
60 70 80 90 100
KCAVDATTMD LLEKLAAAAD LEGRRAAMFA GKKINITEDR AVLHTALRNL
110 120 130 140 150
SGTGVTVDGQ DVKADVLSVL DAMGAFADAI RSGKALGATG KKITDIVNIG
160 170 180 190 200
IGGSDLGPAM ATLALAPYHD GPRAHYVSNI DGAHIHDTLK GLSAETTLFI
210 220 230 240 250
VASKTFTTVE TMTNAQTARD WVQKALGKQA VGKHFAAVST ALDLVAKFGI
260 270 280 290 300
EADRVFGFWD WVGGRYSVWG AIGLPVMIAV GPRNFRAFLD GAHEMDQHFR
310 320 330 340 350
TAPLAGNLPA LLGLVGWWHR VICGYPARAV IPYDQRLSRL PAYLQQLDME
360 370 380 390 400
SNGKGVTLDG TPVATPTGPL VWGEPGTNGQ HAFFQLLHQG TDFIPVEFLA
410 420 430 440 450
AAVGHEPELK HQHDLLLANC LAQSEALMKG RTLDEARAQM LAKGMKPADV
460 470 480 490 500
DKIAPHRVFS GNRPSLTILY RKLDPRTFGR LIALYEHRVF VEGTLFNINS
510 520 530 540
FDQWGVELGK ELATGLLPVV EGKESAANRD ASTRGLVERI HQLRGSE
Length:547
Mass (Da):59,096
Last modified:October 1, 2001 - v1
Checksum:i2275A5B6135BF86F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB51867.1.
RefSeqiNP_106081.1. NC_002678.2.
WP_010913205.1. NC_002678.2.

Genome annotation databases

EnsemblBacteriaiBAB51867; BAB51867; BAB51867.
GeneIDi1228742.
KEGGimlo:mlr5411.
PATRICi22482828. VBIMesLot2464_4295.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB51867.1.
RefSeqiNP_106081.1. NC_002678.2.
WP_010913205.1. NC_002678.2.

3D structure databases

SMRiQ98BV5. Positions 12-546.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266835.mlr5411.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB51867; BAB51867; BAB51867.
GeneIDi1228742.
KEGGimlo:mlr5411.
PATRICi22482828. VBIMesLot2464_4295.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiFELANDC.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciMLOT266835:GJ9L-4230-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MAFF303099.

Entry informationi

Entry nameiG6PI_RHILO
AccessioniPrimary (citable) accession number: Q98BV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: October 1, 2001
Last modified: April 1, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.