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Q98A81 (GLYA2_RHILO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyridoxal-phosphate-dependent serine hydroxymethyltransferase 2
Short name=SHMT 2
Short name=Serine methylase 2
EC=2.1.2.1
Gene names
Name:glyA2
Ordered Locus Names:mlr6114
OrganismRhizobium loti (strain MAFF303099) (Mesorhizobium loti) [Complete proteome] [HAMAP]
Taxonomic identifier266835 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Mesorhizobium

Protein attributes

Sequence length437 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate serving as the one-carbon carrier By similarity.

Catalytic activity

5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. HAMAP MF_00051

Cofactor

Pyridoxal phosphate By similarity. HAMAP MF_00051

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_00051

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity HAMAP MF_00051.

Sequence similarities

Belongs to the SHMT family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 437437Pyridoxal-phosphate-dependent serine hydroxymethyltransferase 2
PRO_0000113647

Regions

Region129 – 1313Substrate binding By similarity

Sites

Binding site391Pyridoxal phosphate By similarity
Binding site591Pyridoxal phosphate By similarity
Binding site611Substrate By similarity
Binding site681Substrate binding By similarity
Binding site691Pyridoxal phosphate By similarity
Binding site1031Pyridoxal phosphate By similarity
Binding site1251Substrate By similarity
Binding site1801Pyridoxal phosphate By similarity
Binding site2081Pyridoxal phosphate By similarity
Binding site2331Pyridoxal phosphate By similarity
Binding site2401Pyridoxal phosphate By similarity
Binding site2791Pyridoxal phosphate; via amide nitrogen and carbonyl oxygen By similarity
Binding site3791Pyridoxal phosphate By similarity

Amino acid modifications

Modified residue2341N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q98A81 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 0DB6E5CAD67F3B61

FASTA43747,991
        10         20         30         40         50         60 
MAEPGTYGRS SLVQVDCRVH ELLLRQRRQE RTMLKLIASE NFASSAVLEA TGSIFANKYA 

        70         80         90        100        110        120 
EGYPGARYYA GNEIVDELET LAIERLKALF GSEHANVQPY SGSPANQAVY RALLSPRDKV 

       130        140        150        160        170        180 
MGLPLPEGGH LTHGWSVNFS GTDYQRVPYG LHDKTQQIDY DRLRETARRE RPKLIWVGGT 

       190        200        210        220        230        240 
SYPRVFDYAA MAEIALEANS YLVADIAHIS GLIVAGAHPN PVVHCDVVTS TSHKSIRGPR 

       250        260        270        280        290        300 
GGFILSKNED RYQALYHSTS KHNLAKRIDR AVFPQLQGGP HMNTIAALAV ALQEAATPSF 

       310        320        330        340        350        360 
RTYGHQIVKN AKALAEALLG RGYYLVTGGT DNHMLILDLR DRPLSGKAYA ERLARAGIIT 

       370        380        390        400        410        420 
NFDMVPGDPR DPTVTSGIRL GSPAVTSMGM REAEMVQIAA FIDSVCRQPD DQEVHASVRR 

       430 
DVADFCTAFD VPGISDR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000012 Genomic DNA. Translation: BAB52456.1.
RefSeqNP_106670.1. NC_002678.2.

3D structure databases

ProteinModelPortalQ98A81.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1229325.
GenomeReviewsGene locus mlr6114 in contig BA000012_GR.
KEGGmlo:mlr6114.
NMPDRfig|266835.1.peg.4771.
PATRIC22483978. VBIMesLot2464_4872.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG301263.
OMARIDRAVF.

Family and domain databases

HAMAPMF_00051. SHMT.
[Tree]
InterProIPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KOK00600.
PANTHERPTHR11680. Gly_HO-Metrfase. 1 hit.
PfamPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFPIRSF000412. SHMT. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITEPS00096. SHMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLYA2_RHILO
AccessionPrimary (citable) accession number: Q98A81
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 1, 2001
Last modified: January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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