Reviewed, UniProtKB/Swiss-Prot Q98A05 (ALR1_RHILO)

Names and origin

Protein names

Recommended name:
    Alanine racemase, biosynthetic
    EC=5.1.1.1

Gene names

Name:	alr
Ordered Locus Names:	mll6211

Organism

Rhizobium loti (Mesorhizobium loti) [Complete proteome] [HAMAP]

Taxonomic identifier

381 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Mesorhizobium

Protein attributes

Sequence length	397 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Provides the D-alanine required for cell wall biosynthesis By similarity.
Catalytic activity	L-alanine = D-alanine. HAMAP MF_01201
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP MF_01201 Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_01201
Sequence similarities	Belongs to the alanine racemase family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	alanine metabolic process Inferred from electronic annotation. Source: HAMAP cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alanine racemase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 397	397	Alanine racemase, biosynthetic HAMAP MF_01201		PRO_0000114551
Sites
	Active site	42	1	Proton acceptor; specific for D-alanine By similarity
	Active site	257	1	Proton acceptor; specific for L-alanine By similarity
Amino acid modifications
	Modified residue	42	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q98A05-1 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 15996F5136A9C307	FASTA	397	43,462
	10 20 30 40 50 60 MMLSIVRSVD VVLEIDLAAI RANFQKISTL VGDKVKVAAV VKSDAYGLGL VDIARTLIDA 70 80 90 100 110 120 GCDLLFVANL DEALLLRSSF SRVAIAVFRD EFDRFGTWYR SHGLIPVVNN CKELHAVGTA 130 140 150 160 170 180 GEPQSYFLNV ETGFSRFGLS VGDIQREYLL RTFERYRPSI VLSHLACGEC ISDPMNQLQR 190 200 210 220 230 240 DRFRTVYDLL KPTRGSLSAS AGVWLGKSYH FDMVRVGSAL YGIHNAGVQT NPLKPVVKLR 250 260 270 280 290 300 ARILDVRSVP AGEAVGYGAT FRTDRASRVA IVGIGYKHGL PWSCANKIFV RLAEYSAPSI 310 320 330 340 350 360 GRISMEYMII DITDVPARRC SPGTFAELLS EDFTVNDLGA AAGVSPQEAL TRLGAGCTRK 370 380 390 YLNLFPPSAA FTANRPTEAM SNPSRAKSRP MDKQALI

References

[1]

"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti." Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S. DNA Res. 7:331-338(2000) [PubMed: 11214968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MAFF303099.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000012 Genomic DNA. Translation: BAB52539.1.
RefSeq	NP_106753.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1229408.
GenomeReviews	Gene locus mll6211 in contig BA000012_GR.
KEGG	mlo:mll6211.
NMPDR	fig|266835.1.peg.4854.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q98A05.
OMA	WITIEAT.
Enzyme and pathway databases
BRENDA	5.1.1.1. 3315.
Family and domain databases
HAMAP	MF_01201. [Tree]
InterPro	IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR000821. Ala_racemase_reg. [Graphical view]
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
TIGRFAMs	TIGR00492. alr. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALR1_RHILO

Accession

Primary (citable) accession number: Q98A05

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	October 1, 2001
Last modified:	November 3, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)