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Q989S7

- PROB2_RHILO

UniProt

Q989S7 - PROB2_RHILO

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Protein
Glutamate 5-kinase 2
Gene
proB2, mlr6298
Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei26 – 261ATP By similarity
Binding sitei67 – 671Substrate By similarity
Binding sitei154 – 1541Substrate By similarity
Binding sitei166 – 1661Substrate; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi186 – 1872ATP By similarity
Nucleotide bindingi228 – 2347ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate 5-kinase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLOT266835:GJ9L-4979-MONOMER.
UniPathwayiUPA00098; UER00359.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate 5-kinase 2 (EC:2.7.2.11)
Alternative name(s):
Gamma-glutamyl kinase 2
Short name:
GK 2
Gene namesi
Name:proB2
Ordered Locus Names:mlr6298
OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
ProteomesiUP000000552: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Glutamate 5-kinase 2UniRule annotation
PRO_0000109714Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266835.mlr6298.

Structurei

3D structure databases

ProteinModelPortaliQ989S7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0263.
HOGENOMiHOG000246368.
KOiK00931.
OMAiAQNAGCT.
OrthoDBiEOG6PGK7G.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
HAMAPiMF_00456. ProB.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000729. GK. 1 hit.
PRINTSiPR00474. GLU5KINASE.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR01027. proB. 1 hit.
PROSITEiPS00902. GLUTAMATE_5_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q989S7-1 [UniParc]FASTAAdd to Basket

« Hide

MQEKIRETCL ATKTVKLLSA RRLIVKIGSA VVADAETGEI RGPWLETLIK    50
DVVRFFARGQ QVIIVTSGAV AAGSRHFKQL DRSLRIEEKQ AAAAIGQIRL 100
MIAYEQSLKR HGFGLGQVLL TSADVDNQRC RLNARSAFQQ LLNVGAVPVI 150
NENDATATPE VCLGDNDRLA ARVAQIAKAD LLILLSDVDG LFTEDPHDNP 200
LARMIPEVRR ITPEIEIMAS LSPARHGSGG MVTKLMAARI AMEAGCNVVI 250
AKGSKSYPLA AIENGAPSTW FIPPARETAT RGGR 284
Length:284
Mass (Da):30,683
Last modified:October 1, 2001 - v1
Checksum:iC7E8BB7D23C4FA54
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000012 Genomic DNA. Translation: BAB52617.1.
RefSeqiNP_106831.1. NC_002678.2.

Genome annotation databases

EnsemblBacteriaiBAB52617; BAB52617; BAB52617.
GeneIDi1229486.
KEGGimlo:mlr6298.
PATRICi22484243. VBIMesLot2464_5004.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000012 Genomic DNA. Translation: BAB52617.1 .
RefSeqi NP_106831.1. NC_002678.2.

3D structure databases

ProteinModelPortali Q989S7.
ModBasei Search...

Protein-protein interaction databases

STRINGi 266835.mlr6298.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB52617 ; BAB52617 ; BAB52617 .
GeneIDi 1229486.
KEGGi mlo:mlr6298.
PATRICi 22484243. VBIMesLot2464_5004.

Phylogenomic databases

eggNOGi COG0263.
HOGENOMi HOG000246368.
KOi K00931.
OMAi AQNAGCT.
OrthoDBi EOG6PGK7G.

Enzyme and pathway databases

UniPathwayi UPA00098 ; UER00359 .
BioCyci MLOT266835:GJ9L-4979-MONOMER.

Family and domain databases

Gene3Di 3.40.1160.10. 1 hit.
HAMAPi MF_00456. ProB.
InterProi IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
[Graphical view ]
Pfami PF00696. AA_kinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000729. GK. 1 hit.
PRINTSi PR00474. GLU5KINASE.
SUPFAMi SSF53633. SSF53633. 1 hit.
TIGRFAMsi TIGR01027. proB. 1 hit.
PROSITEi PS00902. GLUTAMATE_5_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MAFF303099.

Entry informationi

Entry nameiPROB2_RHILO
AccessioniPrimary (citable) accession number: Q989S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: October 1, 2001
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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