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Q989S7

- PROB2_RHILO

UniProt

Q989S7 - PROB2_RHILO

Protein

Glutamate 5-kinase 2

Gene

proB2

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.UniRule annotation

    Catalytic activityi

    ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei26 – 261ATPUniRule annotation
    Binding sitei67 – 671SubstrateUniRule annotation
    Binding sitei154 – 1541SubstrateUniRule annotation
    Binding sitei166 – 1661Substrate; via amide nitrogenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi186 – 1872ATPUniRule annotation
    Nucleotide bindingi228 – 2347ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate 5-kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-proline biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Proline biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMLOT266835:GJ9L-4979-MONOMER.
    UniPathwayiUPA00098; UER00359.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate 5-kinase 2UniRule annotation (EC:2.7.2.11UniRule annotation)
    Alternative name(s):
    Gamma-glutamyl kinase 2UniRule annotation
    Short name:
    GK 2UniRule annotation
    Gene namesi
    Name:proB2UniRule annotation
    Ordered Locus Names:mlr6298
    OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
    Taxonomic identifieri266835 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
    ProteomesiUP000000552: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 284284Glutamate 5-kinase 2PRO_0000109714Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266835.mlr6298.

    Structurei

    3D structure databases

    ProteinModelPortaliQ989S7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamate 5-kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0263.
    HOGENOMiHOG000246368.
    KOiK00931.
    OMAiAQNAGCT.
    OrthoDBiEOG6PGK7G.

    Family and domain databases

    Gene3Di3.40.1160.10. 1 hit.
    HAMAPiMF_00456. ProB.
    InterProiIPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    IPR019797. Glutamate_5-kinase_CS.
    [Graphical view]
    PfamiPF00696. AA_kinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000729. GK. 1 hit.
    PRINTSiPR00474. GLU5KINASE.
    SUPFAMiSSF53633. SSF53633. 1 hit.
    TIGRFAMsiTIGR01027. proB. 1 hit.
    PROSITEiPS00902. GLUTAMATE_5_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q989S7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQEKIRETCL ATKTVKLLSA RRLIVKIGSA VVADAETGEI RGPWLETLIK    50
    DVVRFFARGQ QVIIVTSGAV AAGSRHFKQL DRSLRIEEKQ AAAAIGQIRL 100
    MIAYEQSLKR HGFGLGQVLL TSADVDNQRC RLNARSAFQQ LLNVGAVPVI 150
    NENDATATPE VCLGDNDRLA ARVAQIAKAD LLILLSDVDG LFTEDPHDNP 200
    LARMIPEVRR ITPEIEIMAS LSPARHGSGG MVTKLMAARI AMEAGCNVVI 250
    AKGSKSYPLA AIENGAPSTW FIPPARETAT RGGR 284
    Length:284
    Mass (Da):30,683
    Last modified:October 1, 2001 - v1
    Checksum:iC7E8BB7D23C4FA54
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB52617.1.
    RefSeqiNP_106831.1. NC_002678.2.

    Genome annotation databases

    EnsemblBacteriaiBAB52617; BAB52617; BAB52617.
    GeneIDi1229486.
    KEGGimlo:mlr6298.
    PATRICi22484243. VBIMesLot2464_5004.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB52617.1 .
    RefSeqi NP_106831.1. NC_002678.2.

    3D structure databases

    ProteinModelPortali Q989S7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266835.mlr6298.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB52617 ; BAB52617 ; BAB52617 .
    GeneIDi 1229486.
    KEGGi mlo:mlr6298.
    PATRICi 22484243. VBIMesLot2464_5004.

    Phylogenomic databases

    eggNOGi COG0263.
    HOGENOMi HOG000246368.
    KOi K00931.
    OMAi AQNAGCT.
    OrthoDBi EOG6PGK7G.

    Enzyme and pathway databases

    UniPathwayi UPA00098 ; UER00359 .
    BioCyci MLOT266835:GJ9L-4979-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1160.10. 1 hit.
    HAMAPi MF_00456. ProB.
    InterProi IPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    IPR019797. Glutamate_5-kinase_CS.
    [Graphical view ]
    Pfami PF00696. AA_kinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000729. GK. 1 hit.
    PRINTSi PR00474. GLU5KINASE.
    SUPFAMi SSF53633. SSF53633. 1 hit.
    TIGRFAMsi TIGR01027. proB. 1 hit.
    PROSITEi PS00902. GLUTAMATE_5_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MAFF303099.

    Entry informationi

    Entry nameiPROB2_RHILO
    AccessioniPrimary (citable) accession number: Q989S7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 26, 2002
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3