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Protein

Histidinol dehydrogenase 1

Gene

hisD1

Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG), ATP phosphoribosyltransferase regulatory subunit (hisZ)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase 2 (hisC2), Histidinol-phosphate aminotransferase 3 (hisC3), Histidinol-phosphate aminotransferase 1 (hisC1)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase 3 (hisD3), Histidinol dehydrogenase 1 (hisD1), Histidinol dehydrogenase 2 (hisD2)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei237SubstrateBy similarity1
Metal bindingi259ZincBy similarity1
Binding sitei259SubstrateBy similarity1
Metal bindingi262ZincBy similarity1
Binding sitei262SubstrateBy similarity1
Active sitei327Proton acceptorBy similarity1
Active sitei328Proton acceptorBy similarity1
Binding sitei328SubstrateBy similarity1
Metal bindingi361ZincBy similarity1
Binding sitei361SubstrateBy similarity1
Binding sitei415SubstrateBy similarity1
Metal bindingi420ZincBy similarity1
Binding sitei420SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciMLOT266835:G1G20-5175-MONOMER
UniPathwayiUPA00031; UER00014

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase 1 (EC:1.1.1.23)
Short name:
HDH 1
Gene namesi
Name:hisD1
Ordered Locus Names:mll6456
OrganismiMesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001358291 – 430Histidinol dehydrogenase 1Add BLAST430

Interactioni

Protein-protein interaction databases

STRINGi266835.mll6456

Structurei

3D structure databases

ProteinModelPortaliQ989E7
SMRiQ989E7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG4105CEK Bacteria
COG0141 LUCA
HOGENOMiHOG000243914
KOiK00013
OMAiQAEHDPM
OrthoDBiPOG091H03YX

Family and domain databases

CDDicd06572 Histidinol_dh, 1 hit
HAMAPiMF_01024 HisD, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR001692 Histidinol_DH_CS
IPR022695 Histidinol_DH_monofunct
IPR012131 Hstdl_DH
PANTHERiPTHR21256 PTHR21256, 1 hit
PfamiView protein in Pfam
PF00815 Histidinol_dh, 1 hit
PIRSFiPIRSF000099 Histidinol_dh, 1 hit
PRINTSiPR00083 HOLDHDRGNASE
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00069 hisD, 1 hit
PROSITEiView protein in PROSITE
PS00611 HISOL_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q989E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAITLRQSDA DFEQRFAAFL TTKREVSEDV DAGVRQIIAR VRAEGDAALI
60 70 80 90 100
DYTQRFDRAD LKSLGIAVSK QDIAAAYETA DPKAIEALEF ARDRIRSHHE
110 120 130 140 150
RQRPKDDRYT DATGVELGWR WTAIEAVGLY VPGGTASYPS SVLMNAVPAR
160 170 180 190 200
VAGVERVVMV VPAPGGIINP LVLVAADISG VTEIYRVGGA HAIAALAYGT
210 220 230 240 250
ETIKPVAKIV GPGNAYVAAA KRQVFGTVGI DMIAGPSEVL VVADGSNNAD
260 270 280 290 300
WIAADLLAQA EHDVSAQSIL ITDDPAFGKA VEQAVERQLQ TLPRGETAAA
310 320 330 340 350
SWRDFGAVIE VATIEAALPL VDRIAAEHVE LAIDDAEGFL SRMRNAGAVF
360 370 380 390 400
LGRHTPEAIG DYVGGSNHVL PTARSARFSS GLSVLDFVKR TSILKLGPEQ
410 420 430
LRVLAPAAIA LAKAEGLDAH GRSVAIRLNM
Length:430
Mass (Da):45,685
Last modified:October 1, 2001 - v1
Checksum:i4B21C2FAAFB9E532
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB52750.1
RefSeqiWP_010914064.1, NC_002678.2

Genome annotation databases

EnsemblBacteriaiBAB52750; BAB52750; BAB52750
KEGGimlo:mll6456
PATRICifig|266835.9.peg.5127

Similar proteinsi

Entry informationi

Entry nameiHISX1_RHILO
AccessioniPrimary (citable) accession number: Q989E7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health