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Q989E7

- HISX1_RHILO

UniProt

Q989E7 - HISX1_RHILO

Protein

Histidinol dehydrogenase 1

Gene

hisD1

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei237 – 2371SubstrateBy similarity
    Metal bindingi259 – 2591ZincBy similarity
    Binding sitei259 – 2591SubstrateBy similarity
    Metal bindingi262 – 2621ZincBy similarity
    Binding sitei262 – 2621SubstrateBy similarity
    Active sitei327 – 3271Proton acceptorBy similarity
    Active sitei328 – 3281Proton acceptorBy similarity
    Binding sitei328 – 3281SubstrateBy similarity
    Metal bindingi361 – 3611ZincBy similarity
    Binding sitei361 – 3611SubstrateBy similarity
    Binding sitei415 – 4151SubstrateBy similarity
    Metal bindingi420 – 4201ZincBy similarity
    Binding sitei420 – 4201SubstrateBy similarity

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciMLOT266835:GJ9L-5113-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase 1 (EC:1.1.1.23)
    Short name:
    HDH 1
    Gene namesi
    Name:hisD1
    Ordered Locus Names:mll6456
    OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
    Taxonomic identifieri266835 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
    ProteomesiUP000000552: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 430430Histidinol dehydrogenase 1PRO_0000135829Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266835.mll6456.

    Structurei

    3D structure databases

    ProteinModelPortaliQ989E7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiCAIANRI.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q989E7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAITLRQSDA DFEQRFAAFL TTKREVSEDV DAGVRQIIAR VRAEGDAALI    50
    DYTQRFDRAD LKSLGIAVSK QDIAAAYETA DPKAIEALEF ARDRIRSHHE 100
    RQRPKDDRYT DATGVELGWR WTAIEAVGLY VPGGTASYPS SVLMNAVPAR 150
    VAGVERVVMV VPAPGGIINP LVLVAADISG VTEIYRVGGA HAIAALAYGT 200
    ETIKPVAKIV GPGNAYVAAA KRQVFGTVGI DMIAGPSEVL VVADGSNNAD 250
    WIAADLLAQA EHDVSAQSIL ITDDPAFGKA VEQAVERQLQ TLPRGETAAA 300
    SWRDFGAVIE VATIEAALPL VDRIAAEHVE LAIDDAEGFL SRMRNAGAVF 350
    LGRHTPEAIG DYVGGSNHVL PTARSARFSS GLSVLDFVKR TSILKLGPEQ 400
    LRVLAPAAIA LAKAEGLDAH GRSVAIRLNM 430
    Length:430
    Mass (Da):45,685
    Last modified:October 1, 2001 - v1
    Checksum:i4B21C2FAAFB9E532
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB52750.1.
    RefSeqiNP_106964.1. NC_002678.2.

    Genome annotation databases

    EnsemblBacteriaiBAB52750; BAB52750; BAB52750.
    GeneIDi1229619.
    KEGGimlo:mll6456.
    PATRICi22484491. VBIMesLot2464_5127.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB52750.1 .
    RefSeqi NP_106964.1. NC_002678.2.

    3D structure databases

    ProteinModelPortali Q989E7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266835.mll6456.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB52750 ; BAB52750 ; BAB52750 .
    GeneIDi 1229619.
    KEGGi mlo:mll6456.
    PATRICi 22484491. VBIMesLot2464_5127.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi CAIANRI.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci MLOT266835:GJ9L-5113-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MAFF303099.

    Entry informationi

    Entry nameiHISX1_RHILO
    AccessioniPrimary (citable) accession number: Q989E7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3