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Q989E7

- HISX1_RHILO

UniProt

Q989E7 - HISX1_RHILO

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Protein

Histidinol dehydrogenase 1

Gene

hisD1

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Binds 1 zinc ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei237 – 2371SubstrateBy similarity
Metal bindingi259 – 2591ZincBy similarity
Binding sitei259 – 2591SubstrateBy similarity
Metal bindingi262 – 2621ZincBy similarity
Binding sitei262 – 2621SubstrateBy similarity
Active sitei327 – 3271Proton acceptorBy similarity
Active sitei328 – 3281Proton acceptorBy similarity
Binding sitei328 – 3281SubstrateBy similarity
Metal bindingi361 – 3611ZincBy similarity
Binding sitei361 – 3611SubstrateBy similarity
Binding sitei415 – 4151SubstrateBy similarity
Metal bindingi420 – 4201ZincBy similarity
Binding sitei420 – 4201SubstrateBy similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciMLOT266835:GJ9L-5113-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase 1 (EC:1.1.1.23)
Short name:
HDH 1
Gene namesi
Name:hisD1
Ordered Locus Names:mll6456
OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
ProteomesiUP000000552: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Histidinol dehydrogenase 1PRO_0000135829Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266835.mll6456.

Structurei

3D structure databases

ProteinModelPortaliQ989E7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiCAIANRI.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q989E7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAITLRQSDA DFEQRFAAFL TTKREVSEDV DAGVRQIIAR VRAEGDAALI
60 70 80 90 100
DYTQRFDRAD LKSLGIAVSK QDIAAAYETA DPKAIEALEF ARDRIRSHHE
110 120 130 140 150
RQRPKDDRYT DATGVELGWR WTAIEAVGLY VPGGTASYPS SVLMNAVPAR
160 170 180 190 200
VAGVERVVMV VPAPGGIINP LVLVAADISG VTEIYRVGGA HAIAALAYGT
210 220 230 240 250
ETIKPVAKIV GPGNAYVAAA KRQVFGTVGI DMIAGPSEVL VVADGSNNAD
260 270 280 290 300
WIAADLLAQA EHDVSAQSIL ITDDPAFGKA VEQAVERQLQ TLPRGETAAA
310 320 330 340 350
SWRDFGAVIE VATIEAALPL VDRIAAEHVE LAIDDAEGFL SRMRNAGAVF
360 370 380 390 400
LGRHTPEAIG DYVGGSNHVL PTARSARFSS GLSVLDFVKR TSILKLGPEQ
410 420 430
LRVLAPAAIA LAKAEGLDAH GRSVAIRLNM
Length:430
Mass (Da):45,685
Last modified:October 1, 2001 - v1
Checksum:i4B21C2FAAFB9E532
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000012 Genomic DNA. Translation: BAB52750.1.
RefSeqiNP_106964.1. NC_002678.2.

Genome annotation databases

EnsemblBacteriaiBAB52750; BAB52750; BAB52750.
GeneIDi1229619.
KEGGimlo:mll6456.
PATRICi22484491. VBIMesLot2464_5127.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000012 Genomic DNA. Translation: BAB52750.1 .
RefSeqi NP_106964.1. NC_002678.2.

3D structure databases

ProteinModelPortali Q989E7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266835.mll6456.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB52750 ; BAB52750 ; BAB52750 .
GeneIDi 1229619.
KEGGi mlo:mll6456.
PATRICi 22484491. VBIMesLot2464_5127.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi CAIANRI.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci MLOT266835:GJ9L-5113-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MAFF303099.

Entry informationi

Entry nameiHISX1_RHILO
AccessioniPrimary (citable) accession number: Q989E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: October 1, 2001
Last modified: October 1, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3