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Q989E5 (MURA1_RHILO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1

EC=2.5.1.7
Alternative name(s):
Enoylpyruvate transferase 1
UDP-N-acetylglucosamine enolpyruvyl transferase 1
Short name=EPT 1
Gene names
Name:murA1
Ordered Locus Names:mll6459
OrganismRhizobium loti (strain MAFF303099) (Mesorhizobium loti) [Complete proteome] [HAMAP]
Taxonomic identifier266835 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium

Protein attributes

Sequence length430 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity. HAMAP-Rule MF_00111

Catalytic activity

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine. HAMAP-Rule MF_00111

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00111

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00111.

Sequence similarities

Belongs to the EPSP synthase family. MurA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 430430UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 HAMAP-Rule MF_00111
PRO_0000178906

Sites

Active site1261Proton donor By similarity

Amino acid modifications

Modified residue12612-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity

Sequences

Sequence LengthMass (Da)Tools
Q989E5 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 2D35ABD2D463CBBC

FASTA43045,535
        10         20         30         40         50         60 
MDRIRIVGGN KLAGSIPISG AKNAALPLMI ASLLTDDTLT LENVPHLADV EQLIRILGNH 

        70         80         90        100        110        120 
GVDYSVNGRR EKQNEGYSRT INFSARNIVD TTAPYELVSK MRASFWVIGP LLARMGEAKV 

       130        140        150        160        170        180 
SLPGGCAIGT RPVDLFLEGL QALGADLDVD TGYVIAKTKN GRLVGNRYVF PKVSVGATHV 

       190        200        210        220        230        240 
LMMAASLAKG ETVLENAACE PEIVNLAECL NAMGARISGA GTPTITIDGV ESLSGARVRV 

       250        260        270        280        290        300 
IPDRIETGTY AMAVAMTGGD VVLEGARPEL LQTALDVISQ TGAEITQTNS GIRVKRNGAG 

       310        320        330        340        350        360 
ISPVDVTTAP FPAFPTDLQA QFMGLMTMAK GKSRITETIF ENRFMHVQEL ARLGAHITLS 

       370        380        390        400        410        420 
GQTAIVDGVA KLKGAPVMAT DLRASVSLVI AGLAAEGETT VNRVYHLDRG FERLEEKLSN 

       430 
CGAVIERISA 

« Hide

References

[1]"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti."
Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. expand/collapse author list , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S.
DNA Res. 7:331-338(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MAFF303099.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000012 Genomic DNA. Translation: BAB52752.1.
RefSeqNP_106966.1. NC_002678.2.

3D structure databases

ProteinModelPortalQ989E5.
SMRQ989E5. Positions 1-429.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266835.mll6459.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB52752; BAB52752; BAB52752.
GeneID1229621.
KEGGmlo:mll6459.
PATRIC22484495. VBIMesLot2464_5129.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0766.
HOGENOMHOG000075602.
KOK00790.
OMAECESSKL.
OrthoDBEOG68M4GK.

Enzyme and pathway databases

BioCycMLOT266835:GJ9L-5115-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.65.10.10. 2 hits.
HAMAPMF_00111. MurA.
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PANTHERPTHR21090:SF4. PTHR21090:SF4. 1 hit.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMSSF55205. SSF55205. 1 hit.
TIGRFAMsTIGR01072. murA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURA1_RHILO
AccessionPrimary (citable) accession number: Q989E5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: October 1, 2001
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways