Reviewed, UniProtKB/Swiss-Prot Q989E5 (MURA1_RHILO)

Names and origin

Protein names

Recommended name:
    UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1
    EC=2.5.1.7
Alternative name(s):
    Enoylpyruvate transferase 1
    UDP-N-acetylglucosamine enolpyruvyl transferase 1
      Short name=EPT 1

Gene names

Name:	murA1
Ordered Locus Names:	mll6459

Organism

Rhizobium loti (Mesorhizobium loti) [Complete proteome] [HAMAP]

Taxonomic identifier

381 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Mesorhizobium

Protein attributes

Sequence length	430 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity.
Catalytic activity	Phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. HAMAP MF_00111
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00111
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the EPSP synthase family. MurA subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	UDP-N-acetylgalactosamine biosynthetic process Inferred from electronic annotation. Source: InterPro cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 430	430	UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 HAMAP MF_00111		PRO_0000178906
Sites
	Active site	126	1	Proton donor By similarity
	Binding site	126	1	Phosphoenolpyruvate (covalent) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q989E5-1 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 2D35ABD2D463CBBC	FASTA	430	45,535
	10 20 30 40 50 60 MDRIRIVGGN KLAGSIPISG AKNAALPLMI ASLLTDDTLT LENVPHLADV EQLIRILGNH 70 80 90 100 110 120 GVDYSVNGRR EKQNEGYSRT INFSARNIVD TTAPYELVSK MRASFWVIGP LLARMGEAKV 130 140 150 160 170 180 SLPGGCAIGT RPVDLFLEGL QALGADLDVD TGYVIAKTKN GRLVGNRYVF PKVSVGATHV 190 200 210 220 230 240 LMMAASLAKG ETVLENAACE PEIVNLAECL NAMGARISGA GTPTITIDGV ESLSGARVRV 250 260 270 280 290 300 IPDRIETGTY AMAVAMTGGD VVLEGARPEL LQTALDVISQ TGAEITQTNS GIRVKRNGAG 310 320 330 340 350 360 ISPVDVTTAP FPAFPTDLQA QFMGLMTMAK GKSRITETIF ENRFMHVQEL ARLGAHITLS 370 380 390 400 410 420 GQTAIVDGVA KLKGAPVMAT DLRASVSLVI AGLAAEGETT VNRVYHLDRG FERLEEKLSN 430 CGAVIERISA

References

[1]

"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti." Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S. DNA Res. 7:331-338(2000) [PubMed: 11214968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MAFF303099.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000012 Genomic DNA. Translation: BAB52752.1.
RefSeq	NP_106966.1.
3D structure databases
HSSP	HSSP built from PDB template 1DLG based on UniProtKB P33038.
ModBase	Search...
Genome annotation databases
GeneID	1229621.
GenomeReviews	Gene locus mll6459 in contig BA000012_GR.
KEGG	mlo:mll6459.
NMPDR	fig|266835.1.peg.5067.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q989E5.
OMA	VSRVYHL.
Enzyme and pathway databases
BRENDA	2.5.1.7. 3315.
Family and domain databases
HAMAP	MF_00111. [Tree]
InterPro	IPR001986. EPSP_synthase_core. IPR005750. UDP_GlcNAc_COvinyl_MurA. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
PANTHER	PTHR21090:SF4. AcGlu_Tran_MurA. 1 hit.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
ProDom	PD001867. EPSP_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01072. murA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURA1_RHILO

Accession

Primary (citable) accession number: Q989E5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
Last sequence update:	October 1, 2001
Last modified:	November 3, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)