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Protein

UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1

Gene

murA1

Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.UniRule annotation

Catalytic activityi

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei102UDP-N-acetylglucosamineUniRule annotation1
Active sitei126Proton donorUniRule annotation1
Binding sitei317UDP-N-acetylglucosamineUniRule annotation1
Binding sitei339UDP-N-acetylglucosamine; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandPyruvate

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1UniRule annotation (EC:2.5.1.7UniRule annotation)
Alternative name(s):
Enoylpyruvate transferase 1UniRule annotation
UDP-N-acetylglucosamine enolpyruvyl transferase 1UniRule annotation
Short name:
EPT 1UniRule annotation
Gene namesi
Name:murA1UniRule annotation
Ordered Locus Names:mll6459
OrganismiMesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001789061 – 430UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1Add BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1262-(S-cysteinyl)pyruvic acid O-phosphothioketalUniRule annotation1

Proteomic databases

PRIDEiQ989E5

Interactioni

Protein-protein interaction databases

STRINGi266835.mll6459

Structurei

3D structure databases

ProteinModelPortaliQ989E5
SMRiQ989E5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 23Phosphoenolpyruvate bindingUniRule annotation2
Regioni131 – 135UDP-N-acetylglucosamine bindingUniRule annotation5
Regioni172 – 175UDP-N-acetylglucosamine bindingUniRule annotation4

Sequence similaritiesi

Belongs to the EPSP synthase family. MurA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDF Bacteria
COG0766 LUCA
HOGENOMiHOG000075602
KOiK00790
OMAiCDPHRAT
OrthoDBiPOG091H01PG

Family and domain databases

CDDicd01555 UdpNAET, 1 hit
Gene3Di3.65.10.10, 3 hits
HAMAPiMF_00111 MurA, 1 hit
InterProiView protein in InterPro
IPR001986 Enolpyruvate_Tfrase_dom
IPR036968 Enolpyruvate_Tfrase_sf
IPR013792 RNA3'P_cycl/enolpyr_Trfase_a/b
IPR005750 UDP_GlcNAc_COvinyl_MurA
PfamiView protein in Pfam
PF00275 EPSP_synthase, 1 hit
SUPFAMiSSF55205 SSF55205, 1 hit
TIGRFAMsiTIGR01072 murA, 1 hit

Sequencei

Sequence statusi: Complete.

Q989E5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRIRIVGGN KLAGSIPISG AKNAALPLMI ASLLTDDTLT LENVPHLADV
60 70 80 90 100
EQLIRILGNH GVDYSVNGRR EKQNEGYSRT INFSARNIVD TTAPYELVSK
110 120 130 140 150
MRASFWVIGP LLARMGEAKV SLPGGCAIGT RPVDLFLEGL QALGADLDVD
160 170 180 190 200
TGYVIAKTKN GRLVGNRYVF PKVSVGATHV LMMAASLAKG ETVLENAACE
210 220 230 240 250
PEIVNLAECL NAMGARISGA GTPTITIDGV ESLSGARVRV IPDRIETGTY
260 270 280 290 300
AMAVAMTGGD VVLEGARPEL LQTALDVISQ TGAEITQTNS GIRVKRNGAG
310 320 330 340 350
ISPVDVTTAP FPAFPTDLQA QFMGLMTMAK GKSRITETIF ENRFMHVQEL
360 370 380 390 400
ARLGAHITLS GQTAIVDGVA KLKGAPVMAT DLRASVSLVI AGLAAEGETT
410 420 430
VNRVYHLDRG FERLEEKLSN CGAVIERISA
Length:430
Mass (Da):45,535
Last modified:October 1, 2001 - v1
Checksum:i2D35ABD2D463CBBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB52752.1
RefSeqiWP_010914066.1, NC_002678.2

Genome annotation databases

EnsemblBacteriaiBAB52752; BAB52752; BAB52752
GeneIDi31698527
KEGGimlo:mll6459

Similar proteinsi

Entry informationi

Entry nameiMURA1_RHILO
AccessioniPrimary (citable) accession number: Q989E5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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