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Q989E5

- MURA1_RHILO

UniProt

Q989E5 - MURA1_RHILO

Protein

UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1

Gene

murA1

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.UniRule annotation

    Catalytic activityi

    Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei126 – 1261Proton donorUniRule annotation

    GO - Molecular functioni

    1. UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    4. regulation of cell shape Source: UniProtKB-KW
    5. UDP-N-acetylgalactosamine biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Keywords - Ligandi

    Pyruvate

    Enzyme and pathway databases

    BioCyciMLOT266835:GJ9L-5115-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1UniRule annotation (EC:2.5.1.7UniRule annotation)
    Alternative name(s):
    Enoylpyruvate transferase 1UniRule annotation
    UDP-N-acetylglucosamine enolpyruvyl transferase 1UniRule annotation
    Short name:
    EPT 1UniRule annotation
    Gene namesi
    Name:murA1UniRule annotation
    Ordered Locus Names:mll6459
    OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
    Taxonomic identifieri266835 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
    ProteomesiUP000000552: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 430430UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1PRO_0000178906Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei126 – 12612-(S-cysteinyl)pyruvic acid O-phosphothioketalUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi266835.mll6459.

    Structurei

    3D structure databases

    ProteinModelPortaliQ989E5.
    SMRiQ989E5. Positions 1-429.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the EPSP synthase family. MurA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0766.
    HOGENOMiHOG000075602.
    KOiK00790.
    OMAiECESSKL.
    OrthoDBiEOG68M4GK.

    Family and domain databases

    Gene3Di3.65.10.10. 2 hits.
    HAMAPiMF_00111. MurA.
    InterProiIPR001986. Enolpyruvate_Tfrase_dom.
    IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
    IPR005750. UDP_GlcNAc_COvinyl_MurA.
    [Graphical view]
    PANTHERiPTHR21090:SF4. PTHR21090:SF4. 1 hit.
    PfamiPF00275. EPSP_synthase. 1 hit.
    [Graphical view]
    SUPFAMiSSF55205. SSF55205. 1 hit.
    TIGRFAMsiTIGR01072. murA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q989E5-1 [UniParc]FASTAAdd to Basket

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    MDRIRIVGGN KLAGSIPISG AKNAALPLMI ASLLTDDTLT LENVPHLADV    50
    EQLIRILGNH GVDYSVNGRR EKQNEGYSRT INFSARNIVD TTAPYELVSK 100
    MRASFWVIGP LLARMGEAKV SLPGGCAIGT RPVDLFLEGL QALGADLDVD 150
    TGYVIAKTKN GRLVGNRYVF PKVSVGATHV LMMAASLAKG ETVLENAACE 200
    PEIVNLAECL NAMGARISGA GTPTITIDGV ESLSGARVRV IPDRIETGTY 250
    AMAVAMTGGD VVLEGARPEL LQTALDVISQ TGAEITQTNS GIRVKRNGAG 300
    ISPVDVTTAP FPAFPTDLQA QFMGLMTMAK GKSRITETIF ENRFMHVQEL 350
    ARLGAHITLS GQTAIVDGVA KLKGAPVMAT DLRASVSLVI AGLAAEGETT 400
    VNRVYHLDRG FERLEEKLSN CGAVIERISA 430
    Length:430
    Mass (Da):45,535
    Last modified:October 1, 2001 - v1
    Checksum:i2D35ABD2D463CBBC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB52752.1.
    RefSeqiNP_106966.1. NC_002678.2.
    WP_010914066.1. NC_002678.2.

    Genome annotation databases

    EnsemblBacteriaiBAB52752; BAB52752; BAB52752.
    GeneIDi1229621.
    KEGGimlo:mll6459.
    PATRICi22484495. VBIMesLot2464_5129.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB52752.1 .
    RefSeqi NP_106966.1. NC_002678.2.
    WP_010914066.1. NC_002678.2.

    3D structure databases

    ProteinModelPortali Q989E5.
    SMRi Q989E5. Positions 1-429.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266835.mll6459.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB52752 ; BAB52752 ; BAB52752 .
    GeneIDi 1229621.
    KEGGi mlo:mll6459.
    PATRICi 22484495. VBIMesLot2464_5129.

    Phylogenomic databases

    eggNOGi COG0766.
    HOGENOMi HOG000075602.
    KOi K00790.
    OMAi ECESSKL.
    OrthoDBi EOG68M4GK.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci MLOT266835:GJ9L-5115-MONOMER.

    Family and domain databases

    Gene3Di 3.65.10.10. 2 hits.
    HAMAPi MF_00111. MurA.
    InterProi IPR001986. Enolpyruvate_Tfrase_dom.
    IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
    IPR005750. UDP_GlcNAc_COvinyl_MurA.
    [Graphical view ]
    PANTHERi PTHR21090:SF4. PTHR21090:SF4. 1 hit.
    Pfami PF00275. EPSP_synthase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55205. SSF55205. 1 hit.
    TIGRFAMsi TIGR01072. murA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MAFF303099.

    Entry informationi

    Entry nameiMURA1_RHILO
    AccessioniPrimary (citable) accession number: Q989E5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2002
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3