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Protein

5-hydroxytryptamine receptor 1A

Gene

htr1a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca2+ ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity and behavior. Activation of the receptor may play a role in the exit from G0 phase and in promoting DNA synthesis.1 Publication

GO - Molecular functioni

  • G-protein coupled serotonin receptor activity Source: UniProtKB

GO - Biological processi

  • adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: UniProtKB
  • behavior Source: UniProtKB-KW
  • cell proliferation Source: UniProtKB
  • DNA replication Source: UniProtKB
  • regulation of behavior Source: InterPro
  • regulation of hormone secretion Source: InterPro
  • serotonin receptor signaling pathway Source: UniProtKB
  • vasoconstriction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Behavior

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 1A
Short name:
5-HT-1A
Short name:
5-HT1A
Short name:
x5-HT1A
Alternative name(s):
Serotonin receptor 1A
Gene namesi
Name:htr1aBy similarity
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-984751. htr1a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularBy similarityAdd BLAST30
Transmembranei31 – 56Helical; Name=1By similarityAdd BLAST26
Topological domaini57 – 67CytoplasmicBy similarityAdd BLAST11
Transmembranei68 – 92Helical; Name=2By similarityAdd BLAST25
Topological domaini93 – 104ExtracellularBy similarityAdd BLAST12
Transmembranei105 – 126Helical; Name=3By similarityAdd BLAST22
Topological domaini127 – 146CytoplasmicBy similarityAdd BLAST20
Transmembranei147 – 172Helical; Name=4By similarityAdd BLAST26
Topological domaini173 – 185ExtracellularBy similarityAdd BLAST13
Transmembranei186 – 211Helical; Name=5By similarityAdd BLAST26
Topological domaini212 – 332CytoplasmicBy similarityAdd BLAST121
Transmembranei333 – 354Helical; Name=6By similarityAdd BLAST22
Topological domaini355 – 365ExtracellularBy similarityAdd BLAST11
Transmembranei366 – 389Helical; Name=7By similarityAdd BLAST24
Topological domaini390 – 408CytoplasmicBy similarityAdd BLAST19

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002457841 – 4085-hydroxytryptamine receptor 1AAdd BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi103 ↔ 181PROSITE-ProRule annotationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

First expressed in the rostral part of the brain stem at stage 22. At later stages of development, expression is localized to serotonergic neurons. The expression pattern changes in the tadpole of stage 41 where, in addition to serotonergic neurons, expression is also localized to the inner nuclear layer (INL) of the developing retina. This expression pattern continues through to the start of metamorphosis (stage 46). In adults, expressed in the brain, in particular the telencephalon, diencephalon and mesencephalon. In the telencephalic region, expression is localized to the lateral, dorsal and medial pallium, and in the striatum, septum and amygdala. In the mesencephalic region, expression is strongest in the optic tectum and torus semicircularis with moderate levels of expression in tegmental nuclei. In diencephalon, localized to the dorsal and ventral thalamus and the preoptic area of the hypothalamus.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ98998.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni106 – 115Agonist bindingBy similarity10
Regioni345 – 349Agonist bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi127 – 129DRY motif; important for ligand-induced conformation changesBy similarity3
Motifi382 – 386NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity5

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG106962.
KOiK04153.

Family and domain databases

InterProiIPR000610. 5HT1A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF20. PTHR24247:SF20. 2 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00512. 5HT1ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q98998-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDASNNTTSW NILQRGRMGP SWRRCPVSYQ IIASLFLGRS FSAGIFGNAC
60 70 80 90 100
VIAAIALERS LQNVANYLIG SLAVTDLMVS VLVLPMAAQN QVLNKWTLGQ
110 120 130 140 150
VTCDIFISLD VLCCTSSILH LCAIALDRYW AITDPIDYVN KRTPRRAAVL
160 170 180 190 200
ISITWIVGFS ISIPPMLGWR TPEDRSDPNA CRISEDPGYT IYSTFGAFYI
210 220 230 240 250
PLILMLVLYG KIFKAARFRI RKTVKKAEKK KVADTCLSVS QQSPKEKQRG
260 270 280 290 300
AQQELEEVGG AQAQRCVNGA IRHGEEGAVL EIIEVHHYVN SKCHLHCKPV
310 320 330 340 350
PPPEQLPPAL KNDRATEAKR KVALARERKT VKTLGIIMGT FILCWLPFFI
360 370 380 390 400
VALVLPFCET CHMPHLLFDI ITWLGYSNSL LNPIIYAYFN KDFQSAFKKI

IKCKFCRQ
Length:408
Mass (Da):45,788
Last modified:February 1, 1997 - v1
Checksum:i2CB6156F7D53B1B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07901 mRNA. Translation: CAA69208.1.
RefSeqiNP_001079299.1. NM_001085830.1.
UniGeneiXl.1104.

Genome annotation databases

GeneIDi378605.
KEGGixla:378605.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07901 mRNA. Translation: CAA69208.1.
RefSeqiNP_001079299.1. NM_001085830.1.
UniGeneiXl.1104.

3D structure databases

ProteinModelPortaliQ98998.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi378605.
KEGGixla:378605.

Organism-specific databases

CTDi3350.
XenbaseiXB-GENE-984751. htr1a.

Phylogenomic databases

HOVERGENiHBG106962.
KOiK04153.

Family and domain databases

InterProiIPR000610. 5HT1A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF20. PTHR24247:SF20. 2 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00512. 5HT1ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei5HT1A_XENLA
AccessioniPrimary (citable) accession number: Q98998
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: February 1, 1997
Last modified: October 5, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.