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Protein

Tyrosine-protein kinase receptor TYRO3

Gene

TYRO3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, enhances PI3-kinase activity and activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes (By similarity).By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei537ATPPROSITE-ProRule annotation1
Active sitei642Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi511 – 519ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase receptor TYRO3 (EC:2.7.10.1)
Alternative name(s):
Retina-expressed kinase
Short name:
Rek
Gene namesi
Name:TYRO3
Synonyms:REK
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 416ExtracellularSequence analysisAdd BLAST388
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Topological domaini438 – 873CytoplasmicSequence analysisAdd BLAST436

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000034611429 – 873Tyrosine-protein kinase receptor TYRO3Add BLAST845

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi52 ↔ 105PROSITE-ProRule annotation
Disulfide bondi148 ↔ 191PROSITE-ProRule annotation
Glycosylationi179N-linked (GlcNAc...)Sequence analysis1
Glycosylationi184N-linked (GlcNAc...)Sequence analysis1
Glycosylationi218N-linked (GlcNAc...)Sequence analysis1
Glycosylationi228N-linked (GlcNAc...)Sequence analysis1
Glycosylationi281N-linked (GlcNAc...)Sequence analysis1
Glycosylationi353N-linked (GlcNAc...)Sequence analysis1
Glycosylationi367N-linked (GlcNAc...)Sequence analysis1
Modified residuei673Phosphotyrosine; by autocatalysisBy similarity1

Post-translational modificationi

Autophosphorylated on tyrosine residues.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ98949.

Expressioni

Tissue specificityi

Detected in embryonic retina (at protein level). detected in brain, retina, kidney and in retinal Mueller glia-like cells.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000014051.

Structurei

3D structure databases

ProteinModelPortaliQ98949.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 116Ig-like C2-type 1Add BLAST88
Domaini127 – 208Ig-like C2-type 2Add BLAST82
Domaini215 – 308Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST94
Domaini310 – 403Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST94
Domaini505 – 776Protein kinasePROSITE-ProRule annotationAdd BLAST272

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.PROSITE-ProRule annotation
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG6I. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000231685.
HOVERGENiHBG006346.
InParanoidiQ98949.
KOiK05116.
PhylomeDBiQ98949.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF07679. I-set. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q98949-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELRRSMALP RLLLLGLWAA ALRDGAVAAG MKFTGSPIKL KVSQGQPVKL
60 70 80 90 100
NCSLEGMEDP EMLWIKDGAV VQSVDQVYIP VDEDHWIGFL SLKSVERTDS
110 120 130 140 150
GKYWCQVENG GKKEESQQVW LIVEGVPYFT VEPEDVSVSP NAPFHMACAA
160 170 180 190 200
VGPPEPVTIV WWMGDSRVGL PDISPSILNV SGINQSTMFS CEAHNVKGLS
210 220 230 240 250
SSRTATVQIK AMPLPPLNVT VSQVTSSNAS VVWVPGFDGR APLHSCTLQV
260 270 280 290 300
AESPDGQEVS TEVAPVPPFA YGVQGLKHST NYSVRVQCSN EMGSSPFTER
310 320 330 340 350
VYFQTLELAP SSTPQNIHVI QRDPGLVLEW EGVAPDVLKE NVLGYRLEWI
360 370 380 390 400
QDNVTQGEMI VQDTKANLTT WNPLKDLIIR VCVLNSAGCG PWSDLFLLEA
410 420 430 440 450
QEVMGGQRQP PYGTSWVPVA LGILTALVTA VALALILLRK RRKETRFGHA
460 470 480 490 500
FGSVVGRGDP AVHFRAARSF NREGPELIEA TLESVGISDE LKTKLKDVLI
510 520 530 540 550
QEQQFTLGRM LGKGEFGSVR EALLKLDDGS FQKVAVKMLK ADIFTSTDIE
560 570 580 590 600
EFLREAACMK EFDHPHVTKL IGVSLRSRPK GRLPIPMVIL PFMKHGDLHA
610 620 630 640 650
FLLMSRIGEN PFNLPLQTLL KFMIDIASGM EYLSSKNFIH RDLAARNCML
660 670 680 690 700
DENMNVSVAD FGLSKKIYSG DYYRQGCASK LPVKWLALES LADNLYTTHS
710 720 730 740 750
DVWAFGVTMW EIVTRGQTPY AGIENAEIYN YLISGNRLKQ PPECLEDVYD
760 770 780 790 800
LMCRCWHPEP KLRPSFGVLR SQLEMIRGRM STLSLSQDPL YVNIGKDKES
810 820 830 840 850
SVSDPAVHTS FGNTDGDETI AGAAAAAITS DYRYIMSPLC LGDDVEGERH
860 870
PEGQEGENKS LLYELETEGE KSC
Length:873
Mass (Da):96,402
Last modified:February 1, 1997 - v1
Checksum:i6294E173C5D8104E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70045 mRNA. Translation: AAC60041.1.
RefSeqiNP_989958.1. NM_204627.2.
UniGeneiGga.4266.

Genome annotation databases

GeneIDi395336.
KEGGigga:395336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70045 mRNA. Translation: AAC60041.1.
RefSeqiNP_989958.1. NM_204627.2.
UniGeneiGga.4266.

3D structure databases

ProteinModelPortaliQ98949.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000014051.

Proteomic databases

PaxDbiQ98949.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395336.
KEGGigga:395336.

Organism-specific databases

CTDi7301.

Phylogenomic databases

eggNOGiENOG410IG6I. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000231685.
HOVERGENiHBG006346.
InParanoidiQ98949.
KOiK05116.
PhylomeDBiQ98949.

Miscellaneous databases

PROiQ98949.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF07679. I-set. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTYRO3_CHICK
AccessioniPrimary (citable) accession number: Q98949
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.