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Protein
Submitted name:

Membrane type-matrix metalloproteinase

Gene

MT3-MMP

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei247 – 2471UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, MetalloproteaseSAAS annotation, Protease

Keywords - Ligandi

CalciumSAAS annotation, Metal-bindingSAAS annotation, ZincSAAS annotation

Protein family/group databases

MEROPSiM10.016.

Names & Taxonomyi

Protein namesi
Submitted name:
Membrane type-matrix metalloproteinaseImported
Gene namesi
Name:MT3-MMPImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei565 – 58622HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ98947.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025571.

Structurei

3D structure databases

ProteinModelPortaliQ98947.
SMRiQ98947. Positions 124-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini123 – 292170ZnMcInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase M10A family.SAAS annotation
Contains hemopexin repeats.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
HOGENOMiHOG000217928.
HOVERGENiHBG052484.
KOiK07996.

Family and domain databases

Gene3Di2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR024079. MetalloPept_cat_dom.
IPR028697. MMP16.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR021805. Pept_M10A_metallopeptidase_C.
IPR016293. Pept_M10A_stromelysin-type.
IPR021158. Pept_M10A_Zn_BS.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
[Graphical view]
PANTHERiPTHR10201:SF26. PTHR10201:SF26. 2 hits.
PfamiPF11857. DUF3377. 1 hit.
PF00045. Hemopexin. 3 hits.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiSM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
PROSITEiPS00546. CYSTEINE_SWITCH. 1 hit.
PS00024. HEMOPEXIN. 1 hit.
PS51642. HEMOPEXIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q98947-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVLALSTGS RLDFVSQSRV LFLQTCVWIL CATVCKAEQY FNVEVWLQKY
60 70 80 90 100
GYLPPTDPRM SVLRSAETMQ SAIAAMQQFY GINMTGKVDR NTIDWMKKPR
110 120 130 140 150
CGVPDQTRGS SKFNIRRKRY ALTGQKWQHK HIAYSIKNVT PKVGDAETRK
160 170 180 190 200
AIRRAFDVWQ NVTPLTFEEV PYIELENGKR DVDITIIFAS GFHGDSSPFD
210 220 230 240 250
GEGGFLAHAY FPGPGIGGDT HFDSDEPWTL GNPNHDGNDL FLVAVHELGH
260 270 280 290 300
ALGLEHSNDP TAIMAPFYQY METDNFKLPN DDLQGIQKIY GPPDRIPPPT
310 320 330 340 350
RPLPTVPPHR SIPPADPRKN DRQPKPPRPP TGDKPSYPGA KPNICDGNFN
360 370 380 390 400
TLVILRREMF VFKDQWFWRV RNNRVMDGYP MQITYFWRGL PPSIDAVYEN
410 420 430 440 450
SEGNFVFFKS NKFWVFKDTT LQPGYPHDLI TLGSGIPSHG IDSAIWWEDV
460 470 480 490 500
GKTYFFKGDR YWRYGEEMRS MDPGYPKPIT IWKGIPESPQ GAFVHKENGF
510 520 530 540 550
TYFIKEKSTG NSTKMLRVEP GYPRSILKDF MGCDGPTDRD KDRHSPQDDV
560 570 580 590 600
DIIIKLDNTA STVKAIAIVI PCILALCLLV LVYTVFQFKR EGTPRHILYC

KRSMQEWV
Length:608
Mass (Da):69,412
Last modified:February 1, 1997 - v1
Checksum:iC5032FED17640515
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66463 mRNA. Translation: AAB07491.1.
RefSeqiNP_990528.2. NM_205197.2.
UniGeneiGga.2098.

Genome annotation databases

GeneIDi396116.
KEGGigga:396116.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66463 mRNA. Translation: AAB07491.1.
RefSeqiNP_990528.2. NM_205197.2.
UniGeneiGga.2098.

3D structure databases

ProteinModelPortaliQ98947.
SMRiQ98947. Positions 124-292.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025571.

Protein family/group databases

MEROPSiM10.016.

Proteomic databases

PaxDbiQ98947.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396116.
KEGGigga:396116.

Organism-specific databases

CTDi4325.

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
HOGENOMiHOG000217928.
HOVERGENiHBG052484.
KOiK07996.

Miscellaneous databases

NextBioi20816174.

Family and domain databases

Gene3Di2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR024079. MetalloPept_cat_dom.
IPR028697. MMP16.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR021805. Pept_M10A_metallopeptidase_C.
IPR016293. Pept_M10A_stromelysin-type.
IPR021158. Pept_M10A_Zn_BS.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
[Graphical view]
PANTHERiPTHR10201:SF26. PTHR10201:SF26. 2 hits.
PfamiPF11857. DUF3377. 1 hit.
PF00045. Hemopexin. 3 hits.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiSM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
PROSITEiPS00546. CYSTEINE_SWITCH. 1 hit.
PS00024. HEMOPEXIN. 1 hit.
PS51642. HEMOPEXIN_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and developmental expression of a membrane-type matrix metalloproteinase from chicken."
    Yang M., Hayashi K., Hayashi M., Fujii J.T., Kurkinen M.
    J. Biol. Chem. 271:25548-25554(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ98947_CHICK
AccessioniPrimary (citable) accession number: Q98947
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: May 11, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.