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Protein
Submitted name:

Protein tyrosine phosphatase CRYP-2

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1187Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphataseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protein tyrosine phosphatase CRYP-2Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei871 – 895HelicalSequence analysisAdd BLAST25
Transmembranei931 – 952HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PI7X-ray2.59A/B956-1267[»]
ProteinModelPortaliQ98945
SMRiQ98945
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ98945

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini379 – 475Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini485 – 582Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini583 – 679Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini682 – 775Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini776 – 868Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini989 – 1246Tyrosine-protein phosphataseInterPro annotationAdd BLAST258
Domaini1163 – 1237TYR_PHOSPHATASE_2InterPro annotationAdd BLAST75

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0791 Eukaryota
COG5599 LUCA
HOGENOMiHOG000115792
HOVERGENiHBG053763
PhylomeDBiQ98945

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 3 hits
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
SSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 5 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

Q98945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPQFAIAGH ASEPGGGRRG AAARGRGAEE PQPPPPGRSR GRGRRAPRCP
60 70 80 90 100
TAAGGARGGP GARSCLLWLF VLLKNAEPFQ VTVQEDNCIV VSLEASDVVS
110 120 130 140 150
SSSVYVVKIA GESKNYFFQF EEFNSTLPAP VIFNAKYHGL YYIVTLLVVN
160 170 180 190 200
SNMVSKSARS ITVLTKPLPV SSVSIYDYKP SPETGVLFEI QYPEKYNVFT
210 220 230 240 250
RVNISYWEGK DYRTMLYKDF FKGKTVFNHW LPGICYSNIT FQLVSEATFN
260 270 280 290 300
KSTLVEYSGV RHEPKQHRTV PYPPRNISVQ IVPINRNNWE EHSGNFAEES
310 320 330 340 350
FMGQQEIISK EKLSRFPSDP PEIPVVNTTA AWPDYRSNST EYETTSQPYW
360 370 380 390 400
WSNEAESSEG EEEFVNAVPR DYGASEANAS GKLTAEPAPF LPVQMVLTWL
410 420 430 440 450
PPKPPTAFDG FHINIEREEN STELLTVSED THKFVAELKE PGKYKLSVTT
460 470 480 490 500
FSSSGSCEVR GSQSAKTLSF YISPTGEWIE ELTEKPQHVT VTVLSSTTAL
510 520 530 540 550
TSWTASHESG SNGTIVSVVS LTCQKQKESQ RLEKHYCTEV NSSSSLIENL
560 570 580 590 600
VPGAQYQVVV YLRKGPLVGP PSDPVTFSIV PTGIKDLTLY PLGPTAVVLS
610 620 630 640 650
WNRPFLGVFR KYVVEMFYFN PSTMTSEWTT YYEIAATISL TASVRIANLL
660 670 680 690 700
PAWYYNFRVT MVTWGDPELS CCDSSTISFI TAPVAPEITS IEYYNHLLYV
710 720 730 740 750
TWTYGGDGTD LSHSRMLHWM VIAEGKKKIK KSVTRSVMTA VLSLPPGDIY
760 770 780 790 800
NLSVTACTER GSNTSLPQLV KLEPAPPKSL FAVNKTQTSV TLLWVEEGVA
810 820 830 840 850
DFFEVYCQQA GSNQEVKVQE PVTVSSHVVT ISSLTPATSY NCSVTTFSHN
860 870 880 890 900
SPSVPTYIAV STMVTEMNPN IVVISVLAIL SILLIGLLLV TLVVLRRKHL
910 920 930 940 950
QMARECGAGT FVNFASLERD GKLPYNWRRS VFAFLTLLPS CLWTDYLLAF
960 970 980 990 1000
YINPWSKNGL KKRKLTNPVQ LDDFDGYIKD MAKDSDYKFS LQFEELKLIG
1010 1020 1030 1040 1050
LDIPHFAADL PMNRCKNRYT NILPYDFSRV RLVSMNEEEG SDYINANYIP
1060 1070 1080 1090 1100
GYNSPQEYIA TQGPLPETRN DFWKMVLQQK SQIIVMLTQC NEKRRVKCDH
1110 1120 1130 1140 1150
YWPFTEDPIA YGDITVEMLS EEEHTDWVYR NFRISYADEV QDVMHFNYTA
1160 1170 1180 1190 1200
WPDHGVPTAN AAESILQFVQ MVRQKSVKSK GPMIIHCSAG VGRTGTFIAL
1210 1220 1230 1240 1250
DWLLQHIRDH EFVDILGLVS DMRSYRMSMV QTEEQYIFIH QCVQLMWQKK
1260
KQQFCISDVI YENVSKS
Length:1,267
Mass (Da):142,621
Last modified:February 1, 1997 - v1
Checksum:iE40B10DEDA23C51F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65891 mRNA Translation: AAB17968.1
UniGeneiGga.142

Similar proteinsi

Entry informationi

Entry nameiQ98945_CHICK
AccessioniPrimary (citable) accession number: Q98945
Entry historyiIntegrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

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