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Protein
Submitted name:

Protein tyrosine phosphatase CRYP-2

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protein tyrosine phosphatase CRYP-2Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei871 – 895HelicalSequence analysisAdd BLAST25
Transmembranei931 – 952HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • axon Source: UniProtKB
  • dendritic spine Source: UniProtKB
  • growth cone Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • lamellipodium Source: UniProtKB
  • lateral plasma membrane Source: UniProtKB
  • neuron projection Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ98945.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000021332.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PI7X-ray2.59A/B956-1267[»]
ProteinModelPortaliQ98945.
SMRiQ98945.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ98945.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini379 – 475Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini485 – 582Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini583 – 679Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini682 – 775Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini776 – 868Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini989 – 1246Tyrosine-protein phosphataseInterPro annotationAdd BLAST258
Domaini1163 – 1237TYR_PHOSPHATASE_2InterPro annotationAdd BLAST75

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0791. Eukaryota.
COG5599. LUCA.
HOGENOMiHOG000115792.
HOVERGENiHBG053763.
PhylomeDBiQ98945.

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 3 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 4 hits.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 5 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q98945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPQFAIAGH ASEPGGGRRG AAARGRGAEE PQPPPPGRSR GRGRRAPRCP
60 70 80 90 100
TAAGGARGGP GARSCLLWLF VLLKNAEPFQ VTVQEDNCIV VSLEASDVVS
110 120 130 140 150
SSSVYVVKIA GESKNYFFQF EEFNSTLPAP VIFNAKYHGL YYIVTLLVVN
160 170 180 190 200
SNMVSKSARS ITVLTKPLPV SSVSIYDYKP SPETGVLFEI QYPEKYNVFT
210 220 230 240 250
RVNISYWEGK DYRTMLYKDF FKGKTVFNHW LPGICYSNIT FQLVSEATFN
260 270 280 290 300
KSTLVEYSGV RHEPKQHRTV PYPPRNISVQ IVPINRNNWE EHSGNFAEES
310 320 330 340 350
FMGQQEIISK EKLSRFPSDP PEIPVVNTTA AWPDYRSNST EYETTSQPYW
360 370 380 390 400
WSNEAESSEG EEEFVNAVPR DYGASEANAS GKLTAEPAPF LPVQMVLTWL
410 420 430 440 450
PPKPPTAFDG FHINIEREEN STELLTVSED THKFVAELKE PGKYKLSVTT
460 470 480 490 500
FSSSGSCEVR GSQSAKTLSF YISPTGEWIE ELTEKPQHVT VTVLSSTTAL
510 520 530 540 550
TSWTASHESG SNGTIVSVVS LTCQKQKESQ RLEKHYCTEV NSSSSLIENL
560 570 580 590 600
VPGAQYQVVV YLRKGPLVGP PSDPVTFSIV PTGIKDLTLY PLGPTAVVLS
610 620 630 640 650
WNRPFLGVFR KYVVEMFYFN PSTMTSEWTT YYEIAATISL TASVRIANLL
660 670 680 690 700
PAWYYNFRVT MVTWGDPELS CCDSSTISFI TAPVAPEITS IEYYNHLLYV
710 720 730 740 750
TWTYGGDGTD LSHSRMLHWM VIAEGKKKIK KSVTRSVMTA VLSLPPGDIY
760 770 780 790 800
NLSVTACTER GSNTSLPQLV KLEPAPPKSL FAVNKTQTSV TLLWVEEGVA
810 820 830 840 850
DFFEVYCQQA GSNQEVKVQE PVTVSSHVVT ISSLTPATSY NCSVTTFSHN
860 870 880 890 900
SPSVPTYIAV STMVTEMNPN IVVISVLAIL SILLIGLLLV TLVVLRRKHL
910 920 930 940 950
QMARECGAGT FVNFASLERD GKLPYNWRRS VFAFLTLLPS CLWTDYLLAF
960 970 980 990 1000
YINPWSKNGL KKRKLTNPVQ LDDFDGYIKD MAKDSDYKFS LQFEELKLIG
1010 1020 1030 1040 1050
LDIPHFAADL PMNRCKNRYT NILPYDFSRV RLVSMNEEEG SDYINANYIP
1060 1070 1080 1090 1100
GYNSPQEYIA TQGPLPETRN DFWKMVLQQK SQIIVMLTQC NEKRRVKCDH
1110 1120 1130 1140 1150
YWPFTEDPIA YGDITVEMLS EEEHTDWVYR NFRISYADEV QDVMHFNYTA
1160 1170 1180 1190 1200
WPDHGVPTAN AAESILQFVQ MVRQKSVKSK GPMIIHCSAG VGRTGTFIAL
1210 1220 1230 1240 1250
DWLLQHIRDH EFVDILGLVS DMRSYRMSMV QTEEQYIFIH QCVQLMWQKK
1260
KQQFCISDVI YENVSKS
Length:1,267
Mass (Da):142,621
Last modified:February 1, 1997 - v1
Checksum:iE40B10DEDA23C51F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65891 mRNA. Translation: AAB17968.1.
UniGeneiGga.142.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65891 mRNA. Translation: AAB17968.1.
UniGeneiGga.142.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PI7X-ray2.59A/B956-1267[»]
ProteinModelPortaliQ98945.
SMRiQ98945.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000021332.

Proteomic databases

PaxDbiQ98945.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0791. Eukaryota.
COG5599. LUCA.
HOGENOMiHOG000115792.
HOVERGENiHBG053763.
PhylomeDBiQ98945.

Miscellaneous databases

EvolutionaryTraceiQ98945.

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 3 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 4 hits.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 5 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ98945_CHICK
AccessioniPrimary (citable) accession number: Q98945
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.