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Q98943 (CASP2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Caspase-2
Short name=CASP-2
EC=3.4.22.55
Alternative name(s):
ICH-1L/1S
Protease ICH-1

Cleaved into the following 3 chains:

  1. Caspase-2 subunit p18
  2. Caspase-2 subunit p13
  3. Caspase-2 subunit p12
Gene names
Name:CASP2
Synonyms:ICH1
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival By similarity.

Catalytic activity

Strict requirement for an Asp residue at P1, with 316-asp being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-|-.

Subunit structure

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit By similarity.

Sequence similarities

Belongs to the peptidase C14A family.

Contains 1 CARD domain.

Sequence caution

The sequence AAC29881.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processApoptosis
   Coding sequence diversityAlternative splicing
   Molecular functionHydrolase
Protease
Thiol protease
   PTMZymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of apoptotic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular functioncysteine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform ICH-1L (identifier: Q98943-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Only form found in the ovary.
Isoform ICH-1S (identifier: Q98943-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.
     294-424: DETDRGVDQR...YLFPGYVPGK → GVSGIHIHLP...SSCVCLHAPI

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 140140 By similarity
PRO_0000004553
Chain141 – 308168Caspase-2 subunit p18 By similarity
PRO_0000004554
Chain309 – 424116Caspase-2 subunit p13 By similarity
PRO_0000004555
Chain315 – 424110Caspase-2 subunit p12 By similarity
PRO_0000004556

Regions

Domain7 – 9690CARD

Sites

Active site2481 By similarity
Active site2911 By similarity

Natural variations

Alternative sequence1 – 66Missing in isoform ICH-1S.
VSP_000803
Alternative sequence294 – 424131DETDR…YVPGK → GVSGIHIHLPLPCCCHCICC SMRQTGEWIREMAKNGQIPQ AVRRVMQTRKKISSCVCLHA PI in isoform ICH-1S.
VSP_000804

Sequences

Sequence LengthMass (Da)Tools
Isoform ICH-1L [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 792810508B8B2F60

FASTA42447,960
        10         20         30         40         50         60 
MLGACGMQRY HQEALKKNRV MLARELVLKE LMEHMIEKDI ITIEMVEMIQ AKSGSFSQNV 

        70         80         90        100        110        120 
EFLNLLPKRG PNAFSAFCEA LQETKQQHLA EMILKTESSL RHGIATLEQR YGSNLPLPLS 

       130        140        150        160        170        180 
ESCNSKRPRL IVEHSLDSGD GPPIPPVKHC TPEFYRDHQH LAYKLISEPR GLALILSNIH 

       190        200        210        220        230        240 
FSSEKDLEYR SGGDVDCASL ELLFKHLGYQ VTVFHDQSAE EMESALERFS KLPDHQDVDS 

       250        260        270        280        290        300 
CIVALLSHGV EGGVYGTDGK LLQLQEAFRL FDNANCPNLQ NKPKMFFIQA CRGDETDRGV 

       310        320        330        340        350        360 
DQRDGKERSD SPGCEESDAN KEENLKLRLP TRSDMICGYA CLKGTAAMRN TKRGSWYIEA 

       370        380        390        400        410        420 
LTTVFAEDSR DTHVADMLVK VNRQIKQREG YAPGTEFHRC KEMSEYCSTL CRDLYLFPGY 


VPGK

« Hide

Isoform ICH-1S [UniParc].

Checksum: 442946356B20AB78
Show »

FASTA34939,447

References

[1]"Characterization of the avian Ich-1 cDNA and expression of Ich-1L mRNA in the hen ovary."
Johnson A.L., Bridgham J.T., Bergeron L., Yuan J.
Gene 192:227-233(1997) [PubMed: 9224894] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ICH-1L AND ICH-1S).
Strain: White leghorn.
Tissue: Ovarian granulosa cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U64963 mRNA. Translation: AAC29881.1. Different initiation.
IPIIPI00587840.
IPI00591833.
RefSeqNP_001161173.1. NM_001167701.1.
UniGeneGga.504.

3D structure databases

ProteinModelPortalQ98943.
SMRQ98943. Positions 147-304, 326-422.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ98943.

Protein family/group databases

MEROPSC14.006.

Proteomic databases

PRIDEQ98943.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID395857.
KEGGgga:395857.

Organism-specific databases

CTD835.

Phylogenomic databases

eggNOGveNOG10541.
GeneTreeENSGT00560000076835.
HOVERGENHBG103962.

Enzyme and pathway databases

BRENDA3.4.22.55. 1306.

Family and domain databases

InterProIPR001315. CARD.
IPR017350. Caspase_IL-1_beta.
IPR011029. DEATH-like.
IPR011600. Pept_C14_cat.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR002398. Pept_C14_p45.
IPR015917. Pept_C14_p45_core.
[Graphical view]
Gene3DG3DSA:1.10.533.10. DEATH_like. 1 hit.
KOK02186.
PANTHERPTHR10454. Pept_C14_p45. 1 hit.
PfamPF00619. CARD. 1 hit.
PF00656. Peptidase_C14. 1 hit.
[Graphical view]
PIRSFPIRSF038001. Caspase_ICE. 1 hit.
PRINTSPR00376. IL1BCENZYME.
SMARTSM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view]
SUPFAMSSF47986. DEATH_like. 1 hit.
PROSITEPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCASP2_CHICK
AccessionPrimary (citable) accession number: Q98943
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 16, 2011
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

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