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Protein

Caspase-2

Gene

CASP2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (By similarity).By similarity

Catalytic activityi

Strict requirement for an Asp residue at P1, with 316-asp being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-|-.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei248 – 2481By similarity
Active sitei291 – 2911By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BRENDAi3.4.22.55. 1306.

Protein family/group databases

MEROPSiC14.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase-2 (EC:3.4.22.55)
Short name:
CASP-2
Alternative name(s):
ICH-1L/1S
Protease ICH-1
Cleaved into the following 3 chains:
Gene namesi
Name:CASP2
Synonyms:ICH1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 140140By similarityPRO_0000004553Add
BLAST
Chaini141 – 308168Caspase-2 subunit p18By similarityPRO_0000004554Add
BLAST
Chaini309 – 424116Caspase-2 subunit p13By similarityPRO_0000004555Add
BLAST
Chaini315 – 424110Caspase-2 subunit p12By similarityPRO_0000004556Add
BLAST

Keywords - PTMi

Zymogen

Proteomic databases

PaxDbiQ98943.
PRIDEiQ98943.

Interactioni

Subunit structurei

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000029853.

Structurei

3D structure databases

ProteinModelPortaliQ98943.
SMRiQ98943. Positions 147-304, 326-422.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 9690CARDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C14A family.Curated
Contains 1 CARD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
HOGENOMiHOG000290714.
HOVERGENiHBG103962.
InParanoidiQ98943.
KOiK02186.
PhylomeDBiQ98943.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiIPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR011029. DEATH-like_dom.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR017350. Pept_C14A_CASP1-typ.
IPR015917. Pept_C14A_HD.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52129. SSF52129. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform ICH-1L (identifier: Q98943-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLGACGMQRY HQEALKKNRV MLARELVLKE LMEHMIEKDI ITIEMVEMIQ
60 70 80 90 100
AKSGSFSQNV EFLNLLPKRG PNAFSAFCEA LQETKQQHLA EMILKTESSL
110 120 130 140 150
RHGIATLEQR YGSNLPLPLS ESCNSKRPRL IVEHSLDSGD GPPIPPVKHC
160 170 180 190 200
TPEFYRDHQH LAYKLISEPR GLALILSNIH FSSEKDLEYR SGGDVDCASL
210 220 230 240 250
ELLFKHLGYQ VTVFHDQSAE EMESALERFS KLPDHQDVDS CIVALLSHGV
260 270 280 290 300
EGGVYGTDGK LLQLQEAFRL FDNANCPNLQ NKPKMFFIQA CRGDETDRGV
310 320 330 340 350
DQRDGKERSD SPGCEESDAN KEENLKLRLP TRSDMICGYA CLKGTAAMRN
360 370 380 390 400
TKRGSWYIEA LTTVFAEDSR DTHVADMLVK VNRQIKQREG YAPGTEFHRC
410 420
KEMSEYCSTL CRDLYLFPGY VPGK
Note: Only form found in the ovary.
Length:424
Mass (Da):47,960
Last modified:November 1, 1997 - v2
Checksum:i792810508B8B2F60
GO
Isoform ICH-1S (identifier: Q98943-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.
     294-424: DETDRGVDQR...YLFPGYVPGK → GVSGIHIHLP...SSCVCLHAPI

Show »
Length:349
Mass (Da):39,447
Checksum:i442946356B20AB78
GO

Sequence cautioni

The sequence AAC29881.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 66Missing in isoform ICH-1S. 1 PublicationVSP_000803
Alternative sequencei294 – 424131DETDR…YVPGK → GVSGIHIHLPLPCCCHCICC SMRQTGEWIREMAKNGQIPQ AVRRVMQTRKKISSCVCLHA PI in isoform ICH-1S. 1 PublicationVSP_000804Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64963 mRNA. Translation: AAC29881.1. Different initiation.
RefSeqiNP_001161173.1. NM_001167701.1.
UniGeneiGga.504.

Genome annotation databases

GeneIDi395857.
KEGGigga:395857.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64963 mRNA. Translation: AAC29881.1. Different initiation.
RefSeqiNP_001161173.1. NM_001167701.1.
UniGeneiGga.504.

3D structure databases

ProteinModelPortaliQ98943.
SMRiQ98943. Positions 147-304, 326-422.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000029853.

Protein family/group databases

MEROPSiC14.006.

Proteomic databases

PaxDbiQ98943.
PRIDEiQ98943.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395857.
KEGGigga:395857.

Organism-specific databases

CTDi835.

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
HOGENOMiHOG000290714.
HOVERGENiHBG103962.
InParanoidiQ98943.
KOiK02186.
PhylomeDBiQ98943.

Enzyme and pathway databases

BRENDAi3.4.22.55. 1306.

Miscellaneous databases

NextBioi20815924.
PROiQ98943.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiIPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR011029. DEATH-like_dom.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR017350. Pept_C14A_CASP1-typ.
IPR015917. Pept_C14A_HD.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52129. SSF52129. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of the avian Ich-1 cDNA and expression of Ich-1L mRNA in the hen ovary."
    Johnson A.L., Bridgham J.T., Bergeron L., Yuan J.
    Gene 192:227-233(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ICH-1L AND ICH-1S).
    Strain: White leghorn.
    Tissue: Ovarian granulosa cell.

Entry informationi

Entry nameiCASP2_CHICK
AccessioniPrimary (citable) accession number: Q98943
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 13, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.