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Q98936

- PTPRG_CHICK

UniProt

Q98936 - PTPRG_CHICK

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Protein
Receptor-type tyrosine-protein phosphatase gamma
Gene
PTPRG
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1005 – 10051Substrate By similarity
Active sitei1037 – 10371Phosphocysteine intermediate By similarity
Binding sitei1081 – 10811Substrate By similarity
Sitei1328 – 13281Ancestral active site

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor-type tyrosine-protein phosphatase gamma (EC:3.1.3.48)
    Short name:
    Protein-tyrosine phosphatase gamma
    Short name:
    R-PTP-gamma
    Gene namesi
    Name:PTPRG
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 742723Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei743 – 76826Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini769 – 1422654Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919 By similarity
    Add
    BLAST
    Chaini20 – 14221403Receptor-type tyrosine-protein phosphatase gamma
    PRO_0000025443Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi78 ↔ 261 By similarity
    Glycosylationi109 – 1091N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi113 – 1131N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi156 – 1561N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi359 – 3591N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi444 – 4441N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi620 – 6201N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi632 – 6321N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi640 – 6401N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi728 – 7281N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ98936.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000011605.

    Structurei

    3D structure databases

    ProteinModelPortaliQ98936.
    SMRiQ98936. Positions 804-1389.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini58 – 321264Alpha-carbonic anhydrase
    Add
    BLAST
    Domaini349 – 448100Fibronectin type-III
    Add
    BLAST
    Domaini825 – 1096272Tyrosine-protein phosphatase 1
    Add
    BLAST
    Domaini1127 – 1387261Tyrosine-protein phosphatase 2
    Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1037 – 10437Substrate binding By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5599.
    HOGENOMiHOG000060222.
    HOVERGENiHBG053760.
    InParanoidiQ98936.
    KOiK16667.
    PhylomeDBiQ98936.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.10.200.10. 1 hit.
    3.90.190.10. 2 hits.
    InterProiIPR001148. Carbonic_anhydrase_a.
    IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00194. Carb_anhydrase. 1 hit.
    PF00041. fn3. 1 hit.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM01057. Carb_anhydrase. 1 hit.
    SM00060. FN3. 1 hit.
    SM00194. PTPc. 2 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    SSF51069. SSF51069. 1 hit.
    SSF52799. SSF52799. 2 hits.
    PROSITEiPS51144. ALPHA_CA_2. 1 hit.
    PS50853. FN3. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q98936-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRRLLQPCWW IFFLKITSSV LHDVVCFPAL TEGYVGSLHE SRHGSSVQIR     50
    RRKASGDPYW GYSGTYGPEH WVTSSEKCGG SHQSPIDIVD HQAHVLYEYQ 100
    ELQLDGFDNE SSNKTWMKNT GKTVAILLKD DYFVSGAGLP GRFKAEKVEF 150
    HWGQSNGSAG SEHSINGKRF PVEMQIYFYN PDDFDSFGTA VLENREVGAM 200
    AVFFQVSQRD NSALDPIIRG LKGVVHHEKE TFLDPFVLRD LLPTSLGSYY 250
    RYTGSLTTPP CSEIVEWIIF RKPVPISYHQ LEAFYSIFTT EQQDHVKSVE 300
    YLRNNFRPQQ RLNNRKVSKS AVKDAWSQDM TDILENPLGT EASKACSTPP 350
    VNMKVQPVNR TALLVTWNQP ETIYHPPIMN YMISYSWTKN EDEKEKTFTK 400
    DSDKDLKAII SHVSPDILYL FRVQAVCRNE MRSDFSQTML FQANTTRIFE 450
    GTRIVKTGVP TASPASSADM APISSGSSTW TSSGLPFSFV SMATGMGPSS 500
    SGSQATVASV VTSTLLAGLG FSGSSISSFP SSVWPTRLPT AAAPTKQAGR 550
    PVVATTEPAA ASPGPERDSA LTKDGEGAEE GEKDEKSESE DGEREHEEED 600
    EKEAEKKEKS RATAAAEARN STEPSVATAS PNWTAEEEGN KTVSGEEPNQ 650
    NVVPKAGRPE EESFTDADTQ PQPLPSTQVP PAFTDELYLE KIPRRPETTR 700
    KPLPKDNRFL EEYPSDNKFI TINPADKNSS SMATRPSPGK MEWIIPLIVV 750
    SALTFVCLIL LIAVLVYWRK CFQTAHFYVE DSSSPRVVPN ESIPIIPIPD 800
    DMEAIPVKQF VKHISELYSN NQHGFSEDFE EVQRCTADMN ITAEHSNHPD 850
    NKHKNRYINI LAYDHSRVKL RPLPGKDSKH SDYINANYVS GYNKAKAYIA 900
    TQGPLKSTFE DFWRMIWAQH TGIIVMITNL VEKGRRKCDQ YWPTENSEEY 950
    GNIIVTLKST NIHACYTVRP LHGQEHKDEK GSERKPKGRQ NERTVIQYHY 1000
    TQWPDMGVPE YALPVLTFVR RSSAARTPHM GPVVVHCSAG VGRTGTYIVI 1050
    DSMLQQIKDK STVNVLGFLK HIRTQRNYLV QTEEQYIFIH DALLEAILGK 1100
    ETEVSANQLH SYVNSILIPG IGGKTRLEKQ FKLVTQCNAK YVECFSAQKD 1150
    CNKEKNRNSS VVPSERARVG LAPLPGMKGT DYINASYIMG YYRSNENVIT 1200
    QHPLPHTTKD FWRMIWDHNA QIIVMLPDNQ SLAEDEFVYW PSREESMNCE 1250
    AFTVTLISKD RLCLSNEEQI IIHDFILEAT QDDYVLEVRH FQCPKWPNPD 1300
    APISSTFELI NVIKEEALTR DGPTIVHDEY GAVSAGTLCA LTTLSQQLEN 1350
    ENAVDVFQVA KMINLMRPGV FTDIEQYQFL YKAMLSLVST KENGNGPMTL 1400
    DKNGAVMASD ESDPAESMES LV 1422
    Length:1,422
    Mass (Da):159,767
    Last modified:February 1, 1997 - v1
    Checksum:iDD484055993DA74F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U38349 mRNA. Translation: AAB16910.1.
    PIRiT42636.
    RefSeqiNP_989645.1. NM_204314.1.
    UniGeneiGga.2516.

    Genome annotation databases

    GeneIDi374208.
    KEGGigga:374208.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U38349 mRNA. Translation: AAB16910.1 .
    PIRi T42636.
    RefSeqi NP_989645.1. NM_204314.1.
    UniGenei Gga.2516.

    3D structure databases

    ProteinModelPortali Q98936.
    SMRi Q98936. Positions 804-1389.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000011605.

    Proteomic databases

    PaxDbi Q98936.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 374208.
    KEGGi gga:374208.

    Organism-specific databases

    CTDi 5793.

    Phylogenomic databases

    eggNOGi COG5599.
    HOGENOMi HOG000060222.
    HOVERGENi HBG053760.
    InParanoidi Q98936.
    KOi K16667.
    PhylomeDBi Q98936.

    Miscellaneous databases

    NextBioi 20813712.
    PROi Q98936.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.10.200.10. 1 hit.
    3.90.190.10. 2 hits.
    InterProi IPR001148. Carbonic_anhydrase_a.
    IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00194. Carb_anhydrase. 1 hit.
    PF00041. fn3. 1 hit.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM01057. Carb_anhydrase. 1 hit.
    SM00060. FN3. 1 hit.
    SM00194. PTPc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    SSF51069. SSF51069. 1 hit.
    SSF52799. SSF52799. 2 hits.
    PROSITEi PS51144. ALPHA_CA_2. 1 hit.
    PS50853. FN3. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Qinghua X., Xiaojun G., Cong S., Zong S.M., Jong Y.J., Chan J., Wang L.-H.
      Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain and Kidney.

    Entry informationi

    Entry nameiPTPRG_CHICK
    AccessioniPrimary (citable) accession number: Q98936
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: February 1, 1997
    Last modified: June 11, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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