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Q98936

- PTPRG_CHICK

UniProt

Q98936 - PTPRG_CHICK

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Protein

Receptor-type tyrosine-protein phosphatase gamma

Gene
PTPRG
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1005 – 10051Substrate By similarity
Active sitei1037 – 10371Phosphocysteine intermediate By similarity
Binding sitei1081 – 10811Substrate By similarity
Sitei1328 – 13281Ancestral active site

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase gamma (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase gamma
Short name:
R-PTP-gamma
Gene namesi
Name:PTPRG
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 742723Extracellular Reviewed predictionAdd
BLAST
Transmembranei743 – 76826Helical; Reviewed predictionAdd
BLAST
Topological domaini769 – 1422654Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 By similarityAdd
BLAST
Chaini20 – 14221403Receptor-type tyrosine-protein phosphatase gammaPRO_0000025443Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi78 ↔ 261 By similarity
Glycosylationi109 – 1091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi113 – 1131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi156 – 1561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi359 – 3591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi444 – 4441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi620 – 6201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi632 – 6321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi640 – 6401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi728 – 7281N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ98936.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011605.

Structurei

3D structure databases

ProteinModelPortaliQ98936.
SMRiQ98936. Positions 804-1389.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 321264Alpha-carbonic anhydraseAdd
BLAST
Domaini349 – 448100Fibronectin type-IIIAdd
BLAST
Domaini825 – 1096272Tyrosine-protein phosphatase 1Add
BLAST
Domaini1127 – 1387261Tyrosine-protein phosphatase 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1037 – 10437Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000060222.
HOVERGENiHBG053760.
InParanoidiQ98936.
KOiK16667.
PhylomeDBiQ98936.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.200.10. 1 hit.
3.90.190.10. 2 hits.
InterProiIPR001148. Carbonic_anhydrase_a.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00194. Carb_anhydrase. 1 hit.
PF00041. fn3. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM01057. Carb_anhydrase. 1 hit.
SM00060. FN3. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF51069. SSF51069. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS51144. ALPHA_CA_2. 1 hit.
PS50853. FN3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q98936-1 [UniParc]FASTAAdd to Basket

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MRRLLQPCWW IFFLKITSSV LHDVVCFPAL TEGYVGSLHE SRHGSSVQIR     50
RRKASGDPYW GYSGTYGPEH WVTSSEKCGG SHQSPIDIVD HQAHVLYEYQ 100
ELQLDGFDNE SSNKTWMKNT GKTVAILLKD DYFVSGAGLP GRFKAEKVEF 150
HWGQSNGSAG SEHSINGKRF PVEMQIYFYN PDDFDSFGTA VLENREVGAM 200
AVFFQVSQRD NSALDPIIRG LKGVVHHEKE TFLDPFVLRD LLPTSLGSYY 250
RYTGSLTTPP CSEIVEWIIF RKPVPISYHQ LEAFYSIFTT EQQDHVKSVE 300
YLRNNFRPQQ RLNNRKVSKS AVKDAWSQDM TDILENPLGT EASKACSTPP 350
VNMKVQPVNR TALLVTWNQP ETIYHPPIMN YMISYSWTKN EDEKEKTFTK 400
DSDKDLKAII SHVSPDILYL FRVQAVCRNE MRSDFSQTML FQANTTRIFE 450
GTRIVKTGVP TASPASSADM APISSGSSTW TSSGLPFSFV SMATGMGPSS 500
SGSQATVASV VTSTLLAGLG FSGSSISSFP SSVWPTRLPT AAAPTKQAGR 550
PVVATTEPAA ASPGPERDSA LTKDGEGAEE GEKDEKSESE DGEREHEEED 600
EKEAEKKEKS RATAAAEARN STEPSVATAS PNWTAEEEGN KTVSGEEPNQ 650
NVVPKAGRPE EESFTDADTQ PQPLPSTQVP PAFTDELYLE KIPRRPETTR 700
KPLPKDNRFL EEYPSDNKFI TINPADKNSS SMATRPSPGK MEWIIPLIVV 750
SALTFVCLIL LIAVLVYWRK CFQTAHFYVE DSSSPRVVPN ESIPIIPIPD 800
DMEAIPVKQF VKHISELYSN NQHGFSEDFE EVQRCTADMN ITAEHSNHPD 850
NKHKNRYINI LAYDHSRVKL RPLPGKDSKH SDYINANYVS GYNKAKAYIA 900
TQGPLKSTFE DFWRMIWAQH TGIIVMITNL VEKGRRKCDQ YWPTENSEEY 950
GNIIVTLKST NIHACYTVRP LHGQEHKDEK GSERKPKGRQ NERTVIQYHY 1000
TQWPDMGVPE YALPVLTFVR RSSAARTPHM GPVVVHCSAG VGRTGTYIVI 1050
DSMLQQIKDK STVNVLGFLK HIRTQRNYLV QTEEQYIFIH DALLEAILGK 1100
ETEVSANQLH SYVNSILIPG IGGKTRLEKQ FKLVTQCNAK YVECFSAQKD 1150
CNKEKNRNSS VVPSERARVG LAPLPGMKGT DYINASYIMG YYRSNENVIT 1200
QHPLPHTTKD FWRMIWDHNA QIIVMLPDNQ SLAEDEFVYW PSREESMNCE 1250
AFTVTLISKD RLCLSNEEQI IIHDFILEAT QDDYVLEVRH FQCPKWPNPD 1300
APISSTFELI NVIKEEALTR DGPTIVHDEY GAVSAGTLCA LTTLSQQLEN 1350
ENAVDVFQVA KMINLMRPGV FTDIEQYQFL YKAMLSLVST KENGNGPMTL 1400
DKNGAVMASD ESDPAESMES LV 1422
Length:1,422
Mass (Da):159,767
Last modified:February 1, 1997 - v1
Checksum:iDD484055993DA74F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U38349 mRNA. Translation: AAB16910.1.
PIRiT42636.
RefSeqiNP_989645.1. NM_204314.1.
UniGeneiGga.2516.

Genome annotation databases

GeneIDi374208.
KEGGigga:374208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U38349 mRNA. Translation: AAB16910.1 .
PIRi T42636.
RefSeqi NP_989645.1. NM_204314.1.
UniGenei Gga.2516.

3D structure databases

ProteinModelPortali Q98936.
SMRi Q98936. Positions 804-1389.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000011605.

Proteomic databases

PaxDbi Q98936.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 374208.
KEGGi gga:374208.

Organism-specific databases

CTDi 5793.

Phylogenomic databases

eggNOGi COG5599.
HOGENOMi HOG000060222.
HOVERGENi HBG053760.
InParanoidi Q98936.
KOi K16667.
PhylomeDBi Q98936.

Miscellaneous databases

NextBioi 20813712.
PROi Q98936.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.200.10. 1 hit.
3.90.190.10. 2 hits.
InterProi IPR001148. Carbonic_anhydrase_a.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00194. Carb_anhydrase. 1 hit.
PF00041. fn3. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM01057. Carb_anhydrase. 1 hit.
SM00060. FN3. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
SSF51069. SSF51069. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEi PS51144. ALPHA_CA_2. 1 hit.
PS50853. FN3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Qinghua X., Xiaojun G., Cong S., Zong S.M., Jong Y.J., Chan J., Wang L.-H.
    Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain and Kidney.

Entry informationi

Entry nameiPTPRG_CHICK
AccessioniPrimary (citable) accession number: Q98936
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 1997
Last modified: June 11, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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