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Q98936 (PTPRG_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Receptor-type tyrosine-protein phosphatase gamma

Short name=Protein-tyrosine phosphatase gamma
Short name=R-PTP-gamma
EC=3.1.3.48
Gene names
Name:PTPRG
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length1422 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Membrane; Single-pass type I membrane protein Probable.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.

Contains 1 alpha-carbonic anhydrase domain.

Contains 1 fibronectin type-III domain.

Contains 2 tyrosine-protein phosphatase domains.

Ontologies

Keywords
   Cellular componentMembrane
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionHydrolase
Protein phosphatase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 By similarity
Chain20 – 14221403Receptor-type tyrosine-protein phosphatase gamma
PRO_0000025443

Regions

Topological domain20 – 742723Extracellular Potential
Transmembrane743 – 76826Helical; Potential
Topological domain769 – 1422654Cytoplasmic Potential
Domain58 – 321264Alpha-carbonic anhydrase
Domain349 – 448100Fibronectin type-III
Domain825 – 1096272Tyrosine-protein phosphatase 1
Domain1127 – 1387261Tyrosine-protein phosphatase 2
Region1037 – 10437Substrate binding By similarity

Sites

Active site10371Phosphocysteine intermediate By similarity
Binding site10051Substrate By similarity
Binding site10811Substrate By similarity
Site13281Ancestral active site

Amino acid modifications

Glycosylation1091N-linked (GlcNAc...) Potential
Glycosylation1131N-linked (GlcNAc...) Potential
Glycosylation1561N-linked (GlcNAc...) Potential
Glycosylation3591N-linked (GlcNAc...) Potential
Glycosylation4441N-linked (GlcNAc...) Potential
Glycosylation6201N-linked (GlcNAc...) Potential
Glycosylation6321N-linked (GlcNAc...) Potential
Glycosylation6401N-linked (GlcNAc...) Potential
Glycosylation7281N-linked (GlcNAc...) Potential
Disulfide bond78 ↔ 261 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q98936 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: DD484055993DA74F

FASTA1,422159,767
        10         20         30         40         50         60 
MRRLLQPCWW IFFLKITSSV LHDVVCFPAL TEGYVGSLHE SRHGSSVQIR RRKASGDPYW 

        70         80         90        100        110        120 
GYSGTYGPEH WVTSSEKCGG SHQSPIDIVD HQAHVLYEYQ ELQLDGFDNE SSNKTWMKNT 

       130        140        150        160        170        180 
GKTVAILLKD DYFVSGAGLP GRFKAEKVEF HWGQSNGSAG SEHSINGKRF PVEMQIYFYN 

       190        200        210        220        230        240 
PDDFDSFGTA VLENREVGAM AVFFQVSQRD NSALDPIIRG LKGVVHHEKE TFLDPFVLRD 

       250        260        270        280        290        300 
LLPTSLGSYY RYTGSLTTPP CSEIVEWIIF RKPVPISYHQ LEAFYSIFTT EQQDHVKSVE 

       310        320        330        340        350        360 
YLRNNFRPQQ RLNNRKVSKS AVKDAWSQDM TDILENPLGT EASKACSTPP VNMKVQPVNR 

       370        380        390        400        410        420 
TALLVTWNQP ETIYHPPIMN YMISYSWTKN EDEKEKTFTK DSDKDLKAII SHVSPDILYL 

       430        440        450        460        470        480 
FRVQAVCRNE MRSDFSQTML FQANTTRIFE GTRIVKTGVP TASPASSADM APISSGSSTW 

       490        500        510        520        530        540 
TSSGLPFSFV SMATGMGPSS SGSQATVASV VTSTLLAGLG FSGSSISSFP SSVWPTRLPT 

       550        560        570        580        590        600 
AAAPTKQAGR PVVATTEPAA ASPGPERDSA LTKDGEGAEE GEKDEKSESE DGEREHEEED 

       610        620        630        640        650        660 
EKEAEKKEKS RATAAAEARN STEPSVATAS PNWTAEEEGN KTVSGEEPNQ NVVPKAGRPE 

       670        680        690        700        710        720 
EESFTDADTQ PQPLPSTQVP PAFTDELYLE KIPRRPETTR KPLPKDNRFL EEYPSDNKFI 

       730        740        750        760        770        780 
TINPADKNSS SMATRPSPGK MEWIIPLIVV SALTFVCLIL LIAVLVYWRK CFQTAHFYVE 

       790        800        810        820        830        840 
DSSSPRVVPN ESIPIIPIPD DMEAIPVKQF VKHISELYSN NQHGFSEDFE EVQRCTADMN 

       850        860        870        880        890        900 
ITAEHSNHPD NKHKNRYINI LAYDHSRVKL RPLPGKDSKH SDYINANYVS GYNKAKAYIA 

       910        920        930        940        950        960 
TQGPLKSTFE DFWRMIWAQH TGIIVMITNL VEKGRRKCDQ YWPTENSEEY GNIIVTLKST 

       970        980        990       1000       1010       1020 
NIHACYTVRP LHGQEHKDEK GSERKPKGRQ NERTVIQYHY TQWPDMGVPE YALPVLTFVR 

      1030       1040       1050       1060       1070       1080 
RSSAARTPHM GPVVVHCSAG VGRTGTYIVI DSMLQQIKDK STVNVLGFLK HIRTQRNYLV 

      1090       1100       1110       1120       1130       1140 
QTEEQYIFIH DALLEAILGK ETEVSANQLH SYVNSILIPG IGGKTRLEKQ FKLVTQCNAK 

      1150       1160       1170       1180       1190       1200 
YVECFSAQKD CNKEKNRNSS VVPSERARVG LAPLPGMKGT DYINASYIMG YYRSNENVIT 

      1210       1220       1230       1240       1250       1260 
QHPLPHTTKD FWRMIWDHNA QIIVMLPDNQ SLAEDEFVYW PSREESMNCE AFTVTLISKD 

      1270       1280       1290       1300       1310       1320 
RLCLSNEEQI IIHDFILEAT QDDYVLEVRH FQCPKWPNPD APISSTFELI NVIKEEALTR 

      1330       1340       1350       1360       1370       1380 
DGPTIVHDEY GAVSAGTLCA LTTLSQQLEN ENAVDVFQVA KMINLMRPGV FTDIEQYQFL 

      1390       1400       1410       1420 
YKAMLSLVST KENGNGPMTL DKNGAVMASD ESDPAESMES LV 

« Hide

References

[1]Qinghua X., Xiaojun G., Cong S., Zong S.M., Jong Y.J., Chan J., Wang L.-H.
Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain and Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U38349 mRNA. Translation: AAB16910.1.
PIRT42636.
RefSeqNP_989645.1. NM_204314.1.
UniGeneGga.2516.

3D structure databases

ProteinModelPortalQ98936.
SMRQ98936. Positions 804-1389.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000011605.

Proteomic databases

PaxDbQ98936.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID374208.
KEGGgga:374208.

Organism-specific databases

CTD5793.

Phylogenomic databases

eggNOGCOG5599.
HOGENOMHOG000060222.
HOVERGENHBG053760.
InParanoidQ98936.
KOK16667.
PhylomeDBQ98936.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.10.200.10. 1 hit.
InterProIPR001148. Carbonic_anhydrase_a.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00194. Carb_anhydrase. 1 hit.
PF00041. fn3. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM01057. Carb_anhydrase. 1 hit.
SM00060. FN3. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMSSF49265. SSF49265. 1 hit.
SSF51069. SSF51069. 1 hit.
PROSITEPS51144. ALPHA_CA_2. 1 hit.
PS50853. FN3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20813712.
PROQ98936.

Entry information

Entry namePTPRG_CHICK
AccessionPrimary (citable) accession number: Q98936
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families