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Protein

Receptor-type tyrosine-protein phosphatase gamma

Gene

PTPRG

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1005 – 10051SubstrateBy similarity
Active sitei1037 – 10371Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei1081 – 10811SubstrateBy similarity
Sitei1328 – 13281Ancestral active site

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase gamma (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase gamma
Short name:
R-PTP-gamma
Gene namesi
Name:PTPRG
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 742723ExtracellularSequence AnalysisAdd
BLAST
Transmembranei743 – 76826HelicalSequence AnalysisAdd
BLAST
Topological domaini769 – 1422654CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 14221403Receptor-type tyrosine-protein phosphatase gammaPRO_0000025443Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi78 ↔ 261By similarity
Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi359 – 3591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi620 – 6201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi632 – 6321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi640 – 6401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi728 – 7281N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ98936.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011605.

Structurei

3D structure databases

ProteinModelPortaliQ98936.
SMRiQ98936. Positions 804-1389.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 321264Alpha-carbonic anhydraseAdd
BLAST
Domaini349 – 448100Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST
Domaini825 – 1096272Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
BLAST
Domaini1127 – 1387261Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1037 – 10437Substrate bindingBy similarity

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000060222.
HOVERGENiHBG053760.
InParanoidiQ98936.
KOiK16667.
PhylomeDBiQ98936.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.200.10. 1 hit.
3.90.190.10. 2 hits.
InterProiIPR001148. Carbonic_anhydrase_a.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00194. Carb_anhydrase. 1 hit.
PF00041. fn3. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM01057. Carb_anhydrase. 1 hit.
SM00060. FN3. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF51069. SSF51069. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS51144. ALPHA_CA_2. 1 hit.
PS50853. FN3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q98936-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRLLQPCWW IFFLKITSSV LHDVVCFPAL TEGYVGSLHE SRHGSSVQIR
60 70 80 90 100
RRKASGDPYW GYSGTYGPEH WVTSSEKCGG SHQSPIDIVD HQAHVLYEYQ
110 120 130 140 150
ELQLDGFDNE SSNKTWMKNT GKTVAILLKD DYFVSGAGLP GRFKAEKVEF
160 170 180 190 200
HWGQSNGSAG SEHSINGKRF PVEMQIYFYN PDDFDSFGTA VLENREVGAM
210 220 230 240 250
AVFFQVSQRD NSALDPIIRG LKGVVHHEKE TFLDPFVLRD LLPTSLGSYY
260 270 280 290 300
RYTGSLTTPP CSEIVEWIIF RKPVPISYHQ LEAFYSIFTT EQQDHVKSVE
310 320 330 340 350
YLRNNFRPQQ RLNNRKVSKS AVKDAWSQDM TDILENPLGT EASKACSTPP
360 370 380 390 400
VNMKVQPVNR TALLVTWNQP ETIYHPPIMN YMISYSWTKN EDEKEKTFTK
410 420 430 440 450
DSDKDLKAII SHVSPDILYL FRVQAVCRNE MRSDFSQTML FQANTTRIFE
460 470 480 490 500
GTRIVKTGVP TASPASSADM APISSGSSTW TSSGLPFSFV SMATGMGPSS
510 520 530 540 550
SGSQATVASV VTSTLLAGLG FSGSSISSFP SSVWPTRLPT AAAPTKQAGR
560 570 580 590 600
PVVATTEPAA ASPGPERDSA LTKDGEGAEE GEKDEKSESE DGEREHEEED
610 620 630 640 650
EKEAEKKEKS RATAAAEARN STEPSVATAS PNWTAEEEGN KTVSGEEPNQ
660 670 680 690 700
NVVPKAGRPE EESFTDADTQ PQPLPSTQVP PAFTDELYLE KIPRRPETTR
710 720 730 740 750
KPLPKDNRFL EEYPSDNKFI TINPADKNSS SMATRPSPGK MEWIIPLIVV
760 770 780 790 800
SALTFVCLIL LIAVLVYWRK CFQTAHFYVE DSSSPRVVPN ESIPIIPIPD
810 820 830 840 850
DMEAIPVKQF VKHISELYSN NQHGFSEDFE EVQRCTADMN ITAEHSNHPD
860 870 880 890 900
NKHKNRYINI LAYDHSRVKL RPLPGKDSKH SDYINANYVS GYNKAKAYIA
910 920 930 940 950
TQGPLKSTFE DFWRMIWAQH TGIIVMITNL VEKGRRKCDQ YWPTENSEEY
960 970 980 990 1000
GNIIVTLKST NIHACYTVRP LHGQEHKDEK GSERKPKGRQ NERTVIQYHY
1010 1020 1030 1040 1050
TQWPDMGVPE YALPVLTFVR RSSAARTPHM GPVVVHCSAG VGRTGTYIVI
1060 1070 1080 1090 1100
DSMLQQIKDK STVNVLGFLK HIRTQRNYLV QTEEQYIFIH DALLEAILGK
1110 1120 1130 1140 1150
ETEVSANQLH SYVNSILIPG IGGKTRLEKQ FKLVTQCNAK YVECFSAQKD
1160 1170 1180 1190 1200
CNKEKNRNSS VVPSERARVG LAPLPGMKGT DYINASYIMG YYRSNENVIT
1210 1220 1230 1240 1250
QHPLPHTTKD FWRMIWDHNA QIIVMLPDNQ SLAEDEFVYW PSREESMNCE
1260 1270 1280 1290 1300
AFTVTLISKD RLCLSNEEQI IIHDFILEAT QDDYVLEVRH FQCPKWPNPD
1310 1320 1330 1340 1350
APISSTFELI NVIKEEALTR DGPTIVHDEY GAVSAGTLCA LTTLSQQLEN
1360 1370 1380 1390 1400
ENAVDVFQVA KMINLMRPGV FTDIEQYQFL YKAMLSLVST KENGNGPMTL
1410 1420
DKNGAVMASD ESDPAESMES LV
Length:1,422
Mass (Da):159,767
Last modified:February 1, 1997 - v1
Checksum:iDD484055993DA74F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38349 mRNA. Translation: AAB16910.1.
PIRiT42636.
RefSeqiNP_989645.1. NM_204314.1.
UniGeneiGga.2516.

Genome annotation databases

GeneIDi374208.
KEGGigga:374208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38349 mRNA. Translation: AAB16910.1.
PIRiT42636.
RefSeqiNP_989645.1. NM_204314.1.
UniGeneiGga.2516.

3D structure databases

ProteinModelPortaliQ98936.
SMRiQ98936. Positions 804-1389.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011605.

Proteomic databases

PaxDbiQ98936.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi374208.
KEGGigga:374208.

Organism-specific databases

CTDi5793.

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000060222.
HOVERGENiHBG053760.
InParanoidiQ98936.
KOiK16667.
PhylomeDBiQ98936.

Miscellaneous databases

NextBioi20813712.
PROiQ98936.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.200.10. 1 hit.
3.90.190.10. 2 hits.
InterProiIPR001148. Carbonic_anhydrase_a.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00194. Carb_anhydrase. 1 hit.
PF00041. fn3. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM01057. Carb_anhydrase. 1 hit.
SM00060. FN3. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF51069. SSF51069. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS51144. ALPHA_CA_2. 1 hit.
PS50853. FN3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Qinghua X., Xiaojun G., Cong S., Zong S.M., Jong Y.J., Chan J., Wang L.-H.
    Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain and Kidney.

Entry informationi

Entry nameiPTPRG_CHICK
AccessioniPrimary (citable) accession number: Q98936
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 1997
Last modified: February 4, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.