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Protein

Ras-related protein Rab-5C

Gene

RAB5C

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi28 – 369GTPBy similarity
Nucleotide bindingi47 – 537GTPBy similarity
Nucleotide bindingi76 – 805GTPBy similarity
Nucleotide bindingi134 – 1374GTPBy similarity
Nucleotide bindingi164 – 1663GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-5C
Alternative name(s):
Rab5C-like protein
Gene namesi
Name:RAB5C
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 27

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Ras-related protein Rab-5CPRO_0000276769Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi213 – 2131S-geranylgeranyl cysteineBy similarity
Lipidationi214 – 2141S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

PaxDbiQ98932.
PRIDEiQ98932.

Expressioni

Tissue specificityi

Detected in brain, ovary, rectum, small intestine, large intestine, liver, spleen, follicle and kidney (at protein level).1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039123.

Structurei

3D structure databases

ProteinModelPortaliQ98932.
SMRiQ98932. Positions 16-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi50 – 589Effector regionSequence analysis

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0092. Eukaryota.
ENOG410YCCP. LUCA.
GeneTreeiENSGT00760000119101.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ98932.
KOiK07889.
OMAiGASFFRY.
PhylomeDBiQ98932.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q98932-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRGGAARP NGPAAGNKIC QFKLVLLGES AVGKSSLVLR FVKGQFHEYQ
60 70 80 90 100
ESTIGAAFLT QTVCLDDTTV KFEIWDTAGQ ERYHSLAPMY YRGAQAAIVV
110 120 130 140 150
YDITNTDTFV RAKNWVKELQ RQASPNIVIA LAGNKADLAT KRAVDFQDAQ
160 170 180 190 200
TYADDNSLLF METSAKTAMN VNEIFMAIAK KLPKNEPQNA PGGPGRNRVV
210
DLQESSQPSR SQCCSN
Length:216
Mass (Da):23,554
Last modified:February 1, 1997 - v1
Checksum:i4EF604EE314FE6C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07811 mRNA. Translation: CAA69142.1.
RefSeqiNP_989856.1. NM_204525.1.
XP_015155054.1. XM_015299568.1.
UniGeneiGga.2500.

Genome annotation databases

EnsembliENSGALT00000005312; ENSGALP00000005302; ENSGALG00000003359.
GeneIDi395197.
KEGGigga:395197.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07811 mRNA. Translation: CAA69142.1.
RefSeqiNP_989856.1. NM_204525.1.
XP_015155054.1. XM_015299568.1.
UniGeneiGga.2500.

3D structure databases

ProteinModelPortaliQ98932.
SMRiQ98932. Positions 16-185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039123.

Proteomic databases

PaxDbiQ98932.
PRIDEiQ98932.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000005312; ENSGALP00000005302; ENSGALG00000003359.
GeneIDi395197.
KEGGigga:395197.

Organism-specific databases

CTDi5878.

Phylogenomic databases

eggNOGiKOG0092. Eukaryota.
ENOG410YCCP. LUCA.
GeneTreeiENSGT00760000119101.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ98932.
KOiK07889.
OMAiGASFFRY.
PhylomeDBiQ98932.

Miscellaneous databases

PROiQ98932.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and expression of an avian rab5 homolog."
    Bojer C.D.A., Wohlrab F., Ivessa N.E.
    Biochim. Biophys. Acta 1398:25-31(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
    Tissue: Liver.

Entry informationi

Entry nameiRAB5C_CHICK
AccessioniPrimary (citable) accession number: Q98932
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 1, 1997
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.