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Q988P7 (HISX2_RHILO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase 2

Short name=HDH 2
EC=1.1.1.23
Gene names
Name:hisD2
Ordered Locus Names:mlr6649
OrganismRhizobium loti (strain MAFF303099) (Mesorhizobium loti) [Complete proteome] [HAMAP]
Taxonomic identifier266835 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

histidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Histidinol dehydrogenase 2 HAMAP-Rule MF_01024
PRO_0000135830

Sites

Active site3811Proton acceptor By similarity
Active site3821Proton acceptor By similarity
Metal binding3131Zinc By similarity
Metal binding3161Zinc By similarity
Metal binding4151Zinc By similarity
Metal binding4751Zinc By similarity
Binding site1841NAD By similarity
Binding site2451NAD By similarity
Binding site2681NAD By similarity
Binding site2911Substrate By similarity
Binding site3131Substrate By similarity
Binding site3161Substrate By similarity
Binding site3821Substrate By similarity
Binding site4151Substrate By similarity
Binding site4701Substrate By similarity
Binding site4751Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q988P7 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 71446C53BBF5D9F4

FASTA50054,015
        10         20         30         40         50         60 
MPPAGGIFHR PPTTRKSRRL TPRSACSNST CSRTWGEQPW LLALHSIDSD RNAGRRPCKR 

        70         80         90        100        110        120 
RAIAMIRTIK SARGSVVNGG NGAMTSAVQT LLDQVEQGGD RAVRELSIRF DKFDRDSYRL 

       130        140        150        160        170        180 
TKAEIDACIN SLTGREREDL DFAQDQIRNF AEAQRATLLD LEIETLPGVV LGHRNVPIQN 

       190        200        210        220        230        240 
VGCYVPGGKY PLLASAHMTV LTARVAGCER IITCAPPFQG KVAEKIVAAQ ALAGADEIYC 

       250        260        270        280        290        300 
LGGVQAIAAM AYGTETIAPV DMVAGPGNAY VAEAKRLLFG KVGIDLFAGP TETLVIADDS 

       310        320        330        340        350        360 
VDGELVATDL LGQAEHGVNS PAVLITNSEK LALDTVAEIG RLLTILPTAA IAAKAWEDFG 

       370        380        390        400        410        420 
EIILCETTKE MVAEADRLAS EHVQVMTRDP DHFLNSMRNY GALFLGARTN VSFGDKVIGT 

       430        440        450        460        470        480 
NHTLPTNKAA RYTGGLWVGK FLKTCTYQRI LTDEASALIG EYGSRLSLME GFVGHAEQSN 

       490        500 
IRVRRYGGRN VGYAMPVDPR 

« Hide

References

[1]"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti."
Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. expand/collapse author list , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S.
DNA Res. 7:331-338(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MAFF303099.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000012 Genomic DNA. Translation: BAB52900.1.
RefSeqNP_107114.2. NC_002678.2.

3D structure databases

ProteinModelPortalQ988P7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266835.mlr6649.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB52900; BAB52900; BAB52900.
GeneID1229769.
KEGGmlo:mlr6649.
PATRIC22484805. VBIMesLot2464_5282.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHOG000243914.
KOK15509.
OMAVITCAPP.
OrthoDBEOG6CVVCR.

Enzyme and pathway databases

BioCycMLOT266835:GJ9L-5265-MONOMER.
UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX2_RHILO
AccessionPrimary (citable) accession number: Q988P7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: October 1, 2001
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways