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Q988P7

- HISX2_RHILO

UniProt

Q988P7 - HISX2_RHILO

Protein

Histidinol dehydrogenase 2

Gene

hisD2

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei184 – 1841NADBy similarity
    Binding sitei245 – 2451NADBy similarity
    Binding sitei268 – 2681NADBy similarity
    Binding sitei291 – 2911SubstrateBy similarity
    Metal bindingi313 – 3131ZincBy similarity
    Binding sitei313 – 3131SubstrateBy similarity
    Metal bindingi316 – 3161ZincBy similarity
    Binding sitei316 – 3161SubstrateBy similarity
    Active sitei381 – 3811Proton acceptorBy similarity
    Active sitei382 – 3821Proton acceptorBy similarity
    Binding sitei382 – 3821SubstrateBy similarity
    Metal bindingi415 – 4151ZincBy similarity
    Binding sitei415 – 4151SubstrateBy similarity
    Binding sitei470 – 4701SubstrateBy similarity
    Metal bindingi475 – 4751ZincBy similarity
    Binding sitei475 – 4751SubstrateBy similarity

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciMLOT266835:GJ9L-5265-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase 2 (EC:1.1.1.23)
    Short name:
    HDH 2
    Gene namesi
    Name:hisD2
    Ordered Locus Names:mlr6649
    OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
    Taxonomic identifieri266835 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
    ProteomesiUP000000552: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Histidinol dehydrogenase 2PRO_0000135830Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266835.mlr6649.

    Structurei

    3D structure databases

    ProteinModelPortaliQ988P7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK15509.
    OMAiVITCAPP.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q988P7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPAGGIFHR PPTTRKSRRL TPRSACSNST CSRTWGEQPW LLALHSIDSD    50
    RNAGRRPCKR RAIAMIRTIK SARGSVVNGG NGAMTSAVQT LLDQVEQGGD 100
    RAVRELSIRF DKFDRDSYRL TKAEIDACIN SLTGREREDL DFAQDQIRNF 150
    AEAQRATLLD LEIETLPGVV LGHRNVPIQN VGCYVPGGKY PLLASAHMTV 200
    LTARVAGCER IITCAPPFQG KVAEKIVAAQ ALAGADEIYC LGGVQAIAAM 250
    AYGTETIAPV DMVAGPGNAY VAEAKRLLFG KVGIDLFAGP TETLVIADDS 300
    VDGELVATDL LGQAEHGVNS PAVLITNSEK LALDTVAEIG RLLTILPTAA 350
    IAAKAWEDFG EIILCETTKE MVAEADRLAS EHVQVMTRDP DHFLNSMRNY 400
    GALFLGARTN VSFGDKVIGT NHTLPTNKAA RYTGGLWVGK FLKTCTYQRI 450
    LTDEASALIG EYGSRLSLME GFVGHAEQSN IRVRRYGGRN VGYAMPVDPR 500
    Length:500
    Mass (Da):54,015
    Last modified:October 1, 2001 - v1
    Checksum:i71446C53BBF5D9F4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB52900.1.
    RefSeqiNP_107114.2. NC_002678.2.

    Genome annotation databases

    EnsemblBacteriaiBAB52900; BAB52900; BAB52900.
    GeneIDi1229769.
    KEGGimlo:mlr6649.
    PATRICi22484805. VBIMesLot2464_5282.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB52900.1 .
    RefSeqi NP_107114.2. NC_002678.2.

    3D structure databases

    ProteinModelPortali Q988P7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266835.mlr6649.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB52900 ; BAB52900 ; BAB52900 .
    GeneIDi 1229769.
    KEGGi mlo:mlr6649.
    PATRICi 22484805. VBIMesLot2464_5282.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K15509.
    OMAi VITCAPP.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci MLOT266835:GJ9L-5265-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MAFF303099.

    Entry informationi

    Entry nameiHISX2_RHILO
    AccessioniPrimary (citable) accession number: Q988P7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3