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Q98895 (CNR1B_TAKRU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in cannabinoid-induced CNS effects Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcannabinoid signaling pathway

Inferred from electronic annotation. Source: GOC

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncannabinoid receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 470470Cannabinoid receptor type 1B
PRO_0000069321

Regions

Topological domain1 – 113113Extracellular Potential
Transmembrane114 – 13926Helical; Name=1; Potential
Topological domain140 – 15112Cytoplasmic Potential
Transmembrane152 – 17221Helical; Name=2; Potential
Topological domain173 – 18412Extracellular Potential
Transmembrane185 – 20925Helical; Name=3; Potential
Topological domain210 – 22920Cytoplasmic Potential
Transmembrane230 – 25223Helical; Name=4; Potential
Topological domain253 – 27018Extracellular Potential
Transmembrane271 – 29626Helical; Name=5; Potential
Topological domain297 – 34145Cytoplasmic Potential
Transmembrane342 – 36221Helical; Name=6; Potential
Topological domain363 – 37412Extracellular Potential
Transmembrane375 – 39622Helical; Name=7; Potential
Topological domain397 – 47074Cytoplasmic Potential

Amino acid modifications

Glycosylation781N-linked (GlcNAc...) Potential
Glycosylation861N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q98895 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: CEE87CD37FDF9192

FASTA47052,081
        10         20         30         40         50         60 
MKLALHRIAG ATMAALTTEV QYLGSNDASY EDPQADAALM KSRFNFEKPY SASSSLHRLI 

        70         80         90        100        110        120 
PGNKELIYGG LSTILPTNAS DFPLSNGSGE ATQCGEDIVD NMECFMILTP AQQLVIVILA 

       130        140        150        160        170        180 
ITLGTFTVLE NFVVLCVILH SHTLRSRPSY HFIGSLAVAD LIGSIIFVYS FLDFHVLHRK 

       190        200        210        220        230        240 
DSPSIFLFKL AGVIASFTAS VGSLFLTAID RYVSIHRPMA YKRIITKTKA VIAFSVMWAI 

       250        260        270        280        290        300 
SIEFSLLPLL GWNCKRLHSV CSDIFPLIDE KYLMFWIGMT TVLLLFIIYA YMFILWKSHH 

       310        320        330        340        350        360 
HAVRMLSRSS QRSIIVYTSE GTKVQTVRPE QARMDLRLAK TLVLILVALI ICWGPLLAIM 

       370        380        390        400        410        420 
VYDLFGRVND FIKTVFAFCS MLCLLNSTIN PVIYAMRSKD LRRAFVNICH MCRGTTQSLD 

       430        440        450        460        470 
SSAESDWNSR SVRSTGGRAG KDRSVGGKPQ VKVAQVTVSG VTASSPAEAV

« Hide

References

[1]"Molecular cloning of two cannabinoid type 1-like receptor genes from the puffer fish Fugu rubripes."
Yamaguchi F., Macrae A., Brenner S.
Genomics 35:603-605(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X94402 Genomic DNA. Translation: CAA64175.1.

3D structure databases

ProteinModelPortalQ98895.
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG308746.
InParanoidQ98895.
OrthoDBEOG4J3WH0.

Family and domain databases

InterProIPR002230. Cnbnoid_rcpt.
IPR000810. Cnoid_rcpt_1.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR22750:SF10. PTHR22750:SF10. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PIRSFPIRSF037995. Cnoid_rcpt_1. 1 hit.
PRINTSPR00522. CANABINOID1R.
PR00362. CANNABINOIDR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCNR1B_TAKRU
AccessionPrimary (citable) accession number: Q98895
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 3, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

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