Q98872 (Q98872_DANRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Homeodomain protein Nkx2.5 EMBL AAC05229.1

Gene names

Name:

nkx2.5 EMBL AAC05229.1

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) EMBL AAC05229.1

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus By similarity RuleBase RU000682.

Ontologies

Keywords
Cellular component	Nucleus RuleBase RU000682
Domain	Homeobox RuleBase RU000682 EMBL AAC05229.1
Ligand	DNA-binding RuleBase RU000682
Gene Ontology (GO)
Biological process	embryonic heart tube development Inferred from mutant phenotype. Source: ZFIN heart morphogenesis Inferred from mutant phenotype. Source: ZFIN
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q98872 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 5DE21F1C8D4E22D8	FASTA	314	35,921
	10 20 30 40 50 60 MAMFSSQMTS TPFSVRDILN LEQNQEDMVS LDMSQRLDSA LIPTSSCMLS TFKQEQFMEM 70 80 90 100 110 120 PSGSSLFSED LQEDKGNKIN SLNFSASGFY AKNFLEMDYV KDAKTDDTFE DKEKKDIGFC 130 140 150 160 170 180 QEDPGEDLKL DDAERPKQRK RRKPRVLFSQ AQVYELERRF KQQKYLSAPE RDHLANVLKL 190 200 210 220 230 240 TSTQVKIWFQ NRRYKCKRQR QDQTLEMVGI APPRRISVPV LVRDGKPCLG DTSTYNTSYN 250 260 270 280 290 300 VGINHFTYNT YPAFSNFPSP GNSNYSCNYP SSMSSIQPSQ SNSNYMNFGV GDLNNVQASF 310 QSSSVPSLHG IRAW

References

[1]	"A new tinman-related gene, nkx2.7, anticipates the expression of nkx2.5 and nkx2.3 in zebrafish heart and pharyngeal endoderm." Lee K.H., Xu Q., Breitbart R.E. Dev. Biol. 180:722-731(1996) [PubMed: 8954740] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Wt EMBL AAC05229.1. Tissue: Heart EMBL AAC05229.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U66572 mRNA. Translation: AAC05229.1.
IPI	IPI00502733.
RefSeq	NP_571496.1. NM_131421.1.
UniGene	Dr.271.
3D structure databases
HSSP	HSSP built from PDB template 1FTT based on UniProtKB P23441.
ProteinModelPortal	Q98872.
SMR	Q98872. Positions 141-206.
ModBase	Search...
Protein-protein interaction databases
STRING	Q98872.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	30696.
KEGG	dre:30696.
Organism-specific databases
CTD	30696.
ZFIN	ZDB-GENE-980526-321. nkx2.5.
Phylogenomic databases
GeneTree	ENSGT00590000082895.
HOVERGEN	HBG006689.
InParanoid	Q98872.
Gene expression databases
ArrayExpress	Q98872.
Bgee	Q98872.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR020479. Homeobox_eu. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
KO	K09345.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q98872_DANRE

Accession

Primary (citable) accession number: Q98872

Entry history

Integrated into UniProtKB/TrEMBL:	February 1, 1997
Last sequence update:	February 1, 1997
Last modified:	November 16, 2011
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)