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Q98864 (PTC1_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein patched homolog 1
Short name=PTC1
Short name=Patched 1
Gene names
Name:ptch1
Synonyms:ptc1
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length1220 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Detected in embryonic presomitic mesoderm, neuroectoderm, tissue surrounding the notochord, ventral neural tube.

Developmental stage

At all stages, expression corresponds to the localization of SHH. First detected during gastrulation. By 36 hours, PTC1 appears in the first branchial arch and the posterior mesenchyme of the fin bud; by 48 hours, in the hindbrain and foregut.

Induction

Activated by Sonic hedgehog.

Post-translational modification

Glycosylation is necessary for SHH binding By similarity.

Sequence similarities

Belongs to the patched family.

Contains 1 SSD (sterol-sensing) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12201220Protein patched homolog 1
PRO_0000205967

Regions

Topological domain1 – 8484Cytoplasmic Potential
Transmembrane85 – 10521Helical; Potential
Topological domain106 – 419314Extracellular Potential
Transmembrane420 – 44021Helical; Potential
Topological domain441 – 4499Cytoplasmic Potential
Transmembrane450 – 47021Helical; Potential
Topological domain471 – 48414Extracellular Potential
Transmembrane485 – 50521Helical; Potential
Topological domain506 – 52823Cytoplasmic Potential
Transmembrane529 – 54921Helical; Potential
Topological domain550 – 5589Extracellular Potential
Transmembrane559 – 57921Helical; Potential
Topological domain580 – 739160Cytoplasmic Potential
Transmembrane740 – 76021Helical; Potential
Topological domain761 – 1016256Extracellular Potential
Transmembrane1017 – 103721Helical; Potential
Topological domain1038 – 10447Cytoplasmic Potential
Transmembrane1045 – 106521Helical; Potential
Topological domain1066 – 10727Extracellular Potential
Transmembrane1073 – 109321Helical; Potential
Topological domain1094 – 111017Cytoplasmic Potential
Transmembrane1111 – 113121Helical; Potential
Topological domain1132 – 114312Extracellular Potential
Transmembrane1144 – 116421Helical; Potential
Topological domain1165 – 122056Cytoplasmic Potential
Domain421 – 579159SSD
Compositional bias624 – 69572Thr-rich

Amino acid modifications

Glycosylation3971N-linked (GlcNAc...) Potential
Glycosylation8651N-linked (GlcNAc...) Potential
Glycosylation8881N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q98864 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: D10A9D04115F532D

FASTA1,220135,544
        10         20         30         40         50         60 
MASDPRDPGP AGGVFGDLPP SYTRSPPPVN SDLLRRPSYC HAAFALKQIS KGKAVGQKAP 

        70         80         90        100        110        120 
LWIRARFQAF LFSLGCHIQR HCGKVLFIGL LVFGALSVGL RVAAIETDIE KLWVEAGSRV 

       130        140        150        160        170        180 
SKELRYTKEK QGEESVFTSQ MLIQTPKQEG TNILTQEALL LHLEAALSAS KVQVSLYGKS 

       190        200        210        220        230        240 
WDLNKICFKS GVPIIENVMI ERMIDKLFPC MIVTPLDCFW EGSKLQGGSA YLPGMPDIQW 

       250        260        270        280        290        300 
MNLDPLKLME ELSQFTSLEG FREMLDKAQV GHAYMNRPCL DPSDTDCPHS APNKDPWQVP 

       310        320        330        340        350        360 
NIAAELQGGC HGFSKKFMHW QEELILGERV KDSQNALQSA EALQTMFLLM SPKQLYEHFK 

       370        380        390        400        410        420 
DDYEIHDINW NEDKATAILE SWQRKFVEVV HGSIPQNSSS NVYAFSTTTL NDIMKSFSDV 

       430        440        450        460        470        480 
SVIRVAGGYL LMLAYACVTM LRWDCAKSQG AVGLAGVLLV ALSVAAGLGL CSLLGLSFNA 

       490        500        510        520        530        540 
ATTQVLPSLA LGIGVDDMFL LGHSFTETRS NIPFKERTGD CLRRTGTSVA LTSVNNMIAF 

       550        560        570        580        590        600 
FMAALVPIPA LRAFSLQAAV VVVFNFAMAL LIFPAILSLD LHRREDKRLD ILCCFYSPCS 

       610        620        630        640        650        660 
SRVIQIQPQE LSDANDNHQR APATPTYTGS TITTSTHITT TVQAFTQCDA AGQHIVTILP 

       670        680        690        700        710        720 
PTSQISTTPP SMVLSTPTPT TDPYGSQVFT TSSSTRDLLA QVEEPKEGRE CVPLPFFRWN 

       730        740        750        760        770        780 
LSSFAREKYA PLLLKPETKT VVVVVFVALL SLSLYGTTMV HDGLYLTDIV PRDTQEYEFI 

       790        800        810        820        830        840 
TAQFKYFSFY NMYLVTMDGF DYARSQRQLL QLHNAFNSVK YVVKDGNHKL PRMWLHYFQD 

       850        860        870        880        890        900 
WLKGLQATFD ADWEAGKITY DSYRNGTEDG ALAYKPLIQT GSKKEPFNYS QLTSRRLVDG 

       910        920        930        940        950        960 
DGLIPPEVFY IYLTVWVSND PLGYAASQAN FYPHPREWIH DKYDTTGENL RIPAAEPLEF 

       970        980        990       1000       1010       1020 
AQFPFYLNGL RQASDFIEAI ESVRTICEEF MRQGIKNYPN GYPFLFWEQY IGLRHWFLLS 

      1030       1040       1050       1060       1070       1080 
ISVVLACTFL VCAILLLNPW TAGVIVFILP MMTVELFGIM GLIGIKLSAI PVVILIASVG 

      1090       1100       1110       1120       1130       1140 
IGVEFTVHIA LGFLTAIGDR NTRSAVAMEH MFAPVIDGAI STLLGVLMLA GSEFDFIMRY 

      1150       1160       1170       1180       1190       1200 
FFAVLAILTL LGILNGLVLL PVLLSLMGPP AEVVPANNAN HLQSPSPEPM PPPMNHHGYY 

      1210       1220 
AGHIPKASHQ AFSETSDSEY

« Hide

References

[1]"Spatial regulation of the zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning."
Concordet J.-P., Lewis K.E., Moore J.W., Goodrich L.V., Johnson R.L., Scott M.P., Ingham P.W.
Development 122:2835-2846(1996) [PubMed: 8787757] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X98883 mRNA. Translation: CAA67386.1.
IPIIPI00500992.
PIRT18291.
RefSeqNP_571063.1. NM_130988.1.
UniGeneDr.75755.

3D structure databases

ProteinModelPortalQ98864.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ98864.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID30181.
KEGGdre:30181.

Organism-specific databases

CTD8643.
ZFINZDB-GENE-980526-44. ptc1.

Phylogenomic databases

eggNOGfiNOG07390.
GeneTreeENSGT00550000074234.
HOGENOMHBG713504.
HOVERGENHBG003801.
InParanoidQ98864.
OrthoDBEOG49CQ6V.

Gene expression databases

ArrayExpressQ98864.
BgeeQ98864.

Family and domain databases

InterProIPR003392. Patched.
IPR000731. SSD.
IPR004766. TM_rcpt_patched.
[Graphical view]
KOK06225.
PfamPF02460. Patched. 1 hit.
[Graphical view]
TIGRFAMsTIGR00918. 2A060602. 1 hit.
PROSITEPS50156. SSD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePTC1_DANRE
AccessionPrimary (citable) accession number: Q98864
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: November 16, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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