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Protein

Catalase-peroxidase

Gene

katG

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei93Transition state stabilizerUniRule annotation1
Active sitei97Proton acceptorUniRule annotation1
Metal bindingi260Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei2352. MloCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:mlr6940
OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003548861 – 732Catalase-peroxidaseAdd BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki96 ↔ 219Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-245)UniRule annotation
Cross-linki219 ↔ 245Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-96)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ987S0.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi266835.mlr6940.

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q987S0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAKTDDNSA GKCPVAHGSA GRTNRDWWPN QLNVQILHQQ SSLSDPMGEA
60 70 80 90 100
FDYAEEFKSL DLDAVIKDLH ALMTDSQEWW PADFGHYGPL FIRMAWHSAG
110 120 130 140 150
TYRIADGRGG AGAGQQRFAP LNSWPDNVNL DKARRLLWPI KQKYGRKISW
160 170 180 190 200
ADLLILTGNV ALESMGFKTF GFAGGRADVW EPEQDVYWGP EGKWLADERY
210 220 230 240 250
SGDRDLQNPL GAVQMGLIYV NPEGPNGNPD PLAAARDIRD TFARMAMNDE
260 270 280 290 300
ETVALIAGGH TFGKTHGAGD ASLVGVEPEG ADIEQQGLGW ASKFGTGKGG
310 320 330 340 350
DAIGSGLEVI WTTTPTKWSN NFFDNLFGFD WELTKSPAGA HQWTPKGGAG
360 370 380 390 400
AGTVPDAHNS AKRHAPSMLT TDLALRFDPS YATISKRFHE NPDQFADAFA
410 420 430 440 450
RAWYKLTHRD MGPVARYLGP LVPKEELPWQ DVIPVVDHVL IDEQDAEALK
460 470 480 490 500
AEILASGLSV SQLVSTAWAS ASTFRGSDKR GGANGARIRL SPQKDWAVNQ
510 520 530 540 550
PAELAKVLDK LQAIAKDFNA AQTGSKKVSL ADLIVLGGNA GIEKAAKAAG
560 570 580 590 600
HSVDVPFWPG RMDASQEQTD IHSFAPLEPT VDGFRNYVSG KQRLTVEEAL
610 620 630 640 650
VDRAQLLTLT APELTVLVGG LRVLGANAGQ SKHGVFTKQP ETLSNDFFVN
660 670 680 690 700
LLDMGTEWKA TSDAKDVFEG RDRKTGEVKW TGTRADLIFG SHSQLRALAE
710 720 730
VYATADAKAK FAKDFVVAWT KVMNADRFDI AG
Length:732
Mass (Da):79,645
Last modified:November 25, 2008 - v2
Checksum:i4998DBF4F9C47519
GO

Sequence cautioni

The sequence BAB53130 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB53130.1. Different initiation.
RefSeqiWP_032929051.1. NC_002678.2.

Genome annotation databases

EnsemblBacteriaiBAB53130; BAB53130; BAB53130.
GeneIDi1229999.
KEGGimlo:mlr6940.
PATRICi22485285. VBIMesLot2464_5522.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB53130.1. Different initiation.
RefSeqiWP_032929051.1. NC_002678.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266835.mlr6940.

Protein family/group databases

PeroxiBasei2352. MloCP01.

Proteomic databases

PRIDEiQ987S0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB53130; BAB53130; BAB53130.
GeneIDi1229999.
KEGGimlo:mlr6940.
PATRICi22485285. VBIMesLot2464_5522.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_RHILO
AccessioniPrimary (citable) accession number: Q987S0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.