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Q987N5

- PANE_RHILO

UniProt

Q987N5 - PANE_RHILO

Protein

Putative 2-dehydropantoate 2-reductase

Gene

mll6982

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

    Catalytic activityi

    (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei103 – 1031NADP; via amide nitrogenBy similarity
    Binding sitei103 – 1031SubstrateBy similarity
    Active sitei205 – 2051Proton donorBy similarity
    Binding sitei209 – 2091SubstrateBy similarity
    Binding sitei213 – 2131SubstrateBy similarity
    Binding sitei274 – 2741SubstrateBy similarity
    Binding sitei286 – 2861NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 126NADPBy similarity

    GO - Molecular functioni

    1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciMLOT266835:GJ9L-5533-MONOMER.
    RETL1328306-WGS:GSTH-1747-MONOMER.
    UniPathwayiUPA00028; UER00004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
    Alternative name(s):
    Ketopantoate reductase
    Short name:
    KPA reductase
    Short name:
    KPR
    Gene namesi
    Ordered Locus Names:mll6982
    OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
    Taxonomic identifieri266835 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
    ProteomesiUP000000552: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Putative 2-dehydropantoate 2-reductasePRO_0000157317Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266835.mll6982.

    Structurei

    3D structure databases

    ProteinModelPortaliQ987N5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ketopantoate reductase family.Curated

    Phylogenomic databases

    eggNOGiCOG1893.
    HOGENOMiHOG000050222.
    KOiK00077.
    OMAiTHATLDV.
    OrthoDBiEOG63NMHV.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q987N5-1 [UniParc]FASTAAdd to Basket

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    MKITIFGAGA IGGYLAAKLA IAGRTDLSIV ARGAHLEAIQ ANGLRLIEDG    50
    EESMAPVRAA AKAEELGAQD YVVLALKAHS LTPALDQIAP LLGDHTSVVT 100
    MQNGVPWWYF HGVGGPLEGT RLNAVDPGGA IWQRIGPQRV IGSVVYPAVE 150
    VDAPGLIRHV EGKRFSLGEP SGERSERVTL LAEEMVKAGL QAPVRDDIRS 200
    EIWVKLWGNL SFNPISALTG STLAAIVADE GTRALARTMM LEAQAIGESL 250
    GVRFPIGVDR RIKGAGDVGE HKTSMLQDLE RGRPMEIDAL VSAVQELGRL 300
    VDKPTPTIDA VLALVRRLAV ERGCYS 326
    Length:326
    Mass (Da):34,712
    Last modified:October 1, 2001 - v1
    Checksum:iE1C28123762ACFD2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB53168.1.
    RefSeqiNP_107382.1. NC_002678.2.
    WP_010914475.1. NC_002678.2.

    Genome annotation databases

    EnsemblBacteriaiBAB53168; BAB53168; BAB53168.
    GeneIDi1230037.
    KEGGimlo:mll6982.
    PATRICi22485365. VBIMesLot2464_5562.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB53168.1 .
    RefSeqi NP_107382.1. NC_002678.2.
    WP_010914475.1. NC_002678.2.

    3D structure databases

    ProteinModelPortali Q987N5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266835.mll6982.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB53168 ; BAB53168 ; BAB53168 .
    GeneIDi 1230037.
    KEGGi mlo:mll6982.
    PATRICi 22485365. VBIMesLot2464_5562.

    Phylogenomic databases

    eggNOGi COG1893.
    HOGENOMi HOG000050222.
    KOi K00077.
    OMAi THATLDV.
    OrthoDBi EOG63NMHV.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00004 .
    BioCyci MLOT266835:GJ9L-5533-MONOMER.
    RETL1328306-WGS:GSTH-1747-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MAFF303099.

    Entry informationi

    Entry nameiPANE_RHILO
    AccessioniPrimary (citable) accession number: Q987N5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2002
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3