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Protein

Putative 2-dehydropantoate 2-reductase

Gene

mll6982

Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes (R)-pantoate from 3-methyl-2-oxobutanoate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 3-methyl-2-oxobutanoate hydroxymethyltransferase (panB)
  2. Putative 2-dehydropantoate 2-reductase (mll6982)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantoate from 3-methyl-2-oxobutanoate, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei103NADP; via amide nitrogenBy similarity1
Binding sitei103SubstrateBy similarity1
Active sitei205Proton donorBy similarity1
Binding sitei209SubstrateBy similarity1
Binding sitei213SubstrateBy similarity1
Binding sitei274SubstrateBy similarity1
Binding sitei286NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 12NADPBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPantothenate biosynthesis
LigandNADP

Enzyme and pathway databases

BioCyciMLOT266835:G1G20-5601-MONOMER
UniPathwayiUPA00028; UER00004

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Ordered Locus Names:mll6982
OrganismiMesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001573171 – 326Putative 2-dehydropantoate 2-reductaseAdd BLAST326

Interactioni

Protein-protein interaction databases

STRINGi266835.mll6982

Structurei

3D structure databases

ProteinModelPortaliQ987N5
SMRiQ987N5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ketopantoate reductase family.Curated

Phylogenomic databases

eggNOGiENOG41084M5 Bacteria
COG1893 LUCA
HOGENOMiHOG000050222
KOiK00077
OMAiLWGNMTM
OrthoDBiPOG091H01MS

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR013752 KPA_reductase
IPR013332 KPR_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02558 ApbA, 1 hit
PF08546 ApbA_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 2 hits

Sequencei

Sequence statusi: Complete.

Q987N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKITIFGAGA IGGYLAAKLA IAGRTDLSIV ARGAHLEAIQ ANGLRLIEDG
60 70 80 90 100
EESMAPVRAA AKAEELGAQD YVVLALKAHS LTPALDQIAP LLGDHTSVVT
110 120 130 140 150
MQNGVPWWYF HGVGGPLEGT RLNAVDPGGA IWQRIGPQRV IGSVVYPAVE
160 170 180 190 200
VDAPGLIRHV EGKRFSLGEP SGERSERVTL LAEEMVKAGL QAPVRDDIRS
210 220 230 240 250
EIWVKLWGNL SFNPISALTG STLAAIVADE GTRALARTMM LEAQAIGESL
260 270 280 290 300
GVRFPIGVDR RIKGAGDVGE HKTSMLQDLE RGRPMEIDAL VSAVQELGRL
310 320
VDKPTPTIDA VLALVRRLAV ERGCYS
Length:326
Mass (Da):34,712
Last modified:October 1, 2001 - v1
Checksum:iE1C28123762ACFD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB53168.1
RefSeqiWP_010914475.1, NC_002678.2

Genome annotation databases

EnsemblBacteriaiBAB53168; BAB53168; BAB53168
KEGGimlo:mll6982
PATRICifig|266835.9.peg.5562

Similar proteinsi

Entry informationi

Entry nameiPANE_RHILO
AccessioniPrimary (citable) accession number: Q987N5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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