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Q987N5

- PANE_RHILO

UniProt

Q987N5 - PANE_RHILO

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Protein
Putative 2-dehydropantoate 2-reductase
Gene
mll6982
Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid By similarity.

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei103 – 1031NADP; via amide nitrogen By similarity
Binding sitei103 – 1031Substrate By similarity
Active sitei205 – 2051Proton donor By similarity
Binding sitei209 – 2091Substrate By similarity
Binding sitei213 – 2131Substrate By similarity
Binding sitei274 – 2741Substrate By similarity
Binding sitei286 – 2861NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 126NADP By similarity

GO - Molecular functioni

  1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciMLOT266835:GJ9L-5533-MONOMER.
RETL1328306-WGS:GSTH-1747-MONOMER.
UniPathwayiUPA00028; UER00004.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Ordered Locus Names:mll6982
OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
ProteomesiUP000000552: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Putative 2-dehydropantoate 2-reductase
PRO_0000157317Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266835.mll6982.

Structurei

3D structure databases

ProteinModelPortaliQ987N5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000050222.
KOiK00077.
OMAiTHATLDV.
OrthoDBiEOG63NMHV.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.

Sequencei

Sequence statusi: Complete.

Q987N5-1 [UniParc]FASTAAdd to Basket

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MKITIFGAGA IGGYLAAKLA IAGRTDLSIV ARGAHLEAIQ ANGLRLIEDG    50
EESMAPVRAA AKAEELGAQD YVVLALKAHS LTPALDQIAP LLGDHTSVVT 100
MQNGVPWWYF HGVGGPLEGT RLNAVDPGGA IWQRIGPQRV IGSVVYPAVE 150
VDAPGLIRHV EGKRFSLGEP SGERSERVTL LAEEMVKAGL QAPVRDDIRS 200
EIWVKLWGNL SFNPISALTG STLAAIVADE GTRALARTMM LEAQAIGESL 250
GVRFPIGVDR RIKGAGDVGE HKTSMLQDLE RGRPMEIDAL VSAVQELGRL 300
VDKPTPTIDA VLALVRRLAV ERGCYS 326
Length:326
Mass (Da):34,712
Last modified:October 1, 2001 - v1
Checksum:iE1C28123762ACFD2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000012 Genomic DNA. Translation: BAB53168.1.
RefSeqiNP_107382.1. NC_002678.2.
WP_010914475.1. NC_002678.2.

Genome annotation databases

EnsemblBacteriaiBAB53168; BAB53168; BAB53168.
GeneIDi1230037.
KEGGimlo:mll6982.
PATRICi22485365. VBIMesLot2464_5562.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000012 Genomic DNA. Translation: BAB53168.1 .
RefSeqi NP_107382.1. NC_002678.2.
WP_010914475.1. NC_002678.2.

3D structure databases

ProteinModelPortali Q987N5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 266835.mll6982.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB53168 ; BAB53168 ; BAB53168 .
GeneIDi 1230037.
KEGGi mlo:mll6982.
PATRICi 22485365. VBIMesLot2464_5562.

Phylogenomic databases

eggNOGi COG1893.
HOGENOMi HOG000050222.
KOi K00077.
OMAi THATLDV.
OrthoDBi EOG63NMHV.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00004 .
BioCyci MLOT266835:GJ9L-5533-MONOMER.
RETL1328306-WGS:GSTH-1747-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MAFF303099.

Entry informationi

Entry nameiPANE_RHILO
AccessioniPrimary (citable) accession number: Q987N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: October 1, 2001
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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