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Q987C6

- HISX3_RHILO

UniProt

Q987C6 - HISX3_RHILO

Protein

Histidinol dehydrogenase 3

Gene

hisD3

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi262 – 2621ZincBy similarity
    Metal bindingi265 – 2651ZincBy similarity
    Active sitei333 – 3331Proton acceptorBy similarity
    Active sitei334 – 3341Proton acceptorBy similarity
    Metal bindingi426 – 4261ZincBy similarity

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciMLOT266835:GJ9L-5642-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase 3 (EC:1.1.1.23)
    Short name:
    HDH 3
    Gene namesi
    Name:hisD3
    Ordered Locus Names:mlr7107
    OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
    Taxonomic identifieri266835 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
    ProteomesiUP000000552: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 440440Histidinol dehydrogenase 3PRO_0000135831Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266835.mlr7107.

    Structurei

    3D structure databases

    ProteinModelPortaliQ987C6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYEGFSSH.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q987C6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDVSFHDLS SLDATQRSSL LKRAEADLSV FVEKVRPIIQ AVKDEGDAAL    50
    IRFARELDKA NVAEGGLQVS EAEFDAAFDK VEKDVVESIG FGIDNIRRFH 100
    EEQKPETMWL KEVRPGAYAG DRYTPIASVA LYVPRGKGAF PSVTMMTSVP 150
    AVIAGVPQIA IVTPPTSDGS VDAATLVAAR LAGVHTVYKC GGAQAVAAVA 200
    YGTETVKPAL KIVGPGSPWV VAAKSELSSI INTGLPAGPS EAIIFADDSV 250
    DGGLAALDLL IEAEHGPDSS AYLVTHSRKV AEAALAALPQ HWSRMTEQRV 300
    EFSRAVLTGK RGGIVLTASL EDSYRFINDY APEHLEILSK EPFAHLGHIT 350
    EAAEILMGPH TPVTLANFVL GPNAVLPTSR WARTYGPLSV TDFVKRSSVG 400
    YVTSAAYPEL AKHARRLARY EGFSSHENAV SEIRDRYLAG 440
    Length:440
    Mass (Da):47,089
    Last modified:October 1, 2001 - v1
    Checksum:i76FF8FD9E42CA90C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB53277.1.
    RefSeqiNP_107491.1. NC_002678.2.

    Genome annotation databases

    EnsemblBacteriaiBAB53277; BAB53277; BAB53277.
    GeneIDi1230146.
    KEGGimlo:mlr7107.
    PATRICi22485579. VBIMesLot2464_5669.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB53277.1 .
    RefSeqi NP_107491.1. NC_002678.2.

    3D structure databases

    ProteinModelPortali Q987C6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266835.mlr7107.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB53277 ; BAB53277 ; BAB53277 .
    GeneIDi 1230146.
    KEGGi mlo:mlr7107.
    PATRICi 22485579. VBIMesLot2464_5669.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YEGFSSH.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci MLOT266835:GJ9L-5642-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MAFF303099.

    Entry informationi

    Entry nameiHISX3_RHILO
    AccessioniPrimary (citable) accession number: Q987C6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    The conserved zinc-binding site Asp residue in position 367 is replaced by an Asn.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3