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Q987C6

- HISX3_RHILO

UniProt

Q987C6 - HISX3_RHILO

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Protein

Histidinol dehydrogenase 3

Gene

hisD3

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi262 – 2621ZincBy similarity
Metal bindingi265 – 2651ZincBy similarity
Active sitei333 – 3331Proton acceptorBy similarity
Active sitei334 – 3341Proton acceptorBy similarity
Metal bindingi426 – 4261ZincBy similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciMLOT266835:GJ9L-5642-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase 3 (EC:1.1.1.23)
Short name:
HDH 3
Gene namesi
Name:hisD3
Ordered Locus Names:mlr7107
OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
ProteomesiUP000000552: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 440440Histidinol dehydrogenase 3PRO_0000135831Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266835.mlr7107.

Structurei

3D structure databases

ProteinModelPortaliQ987C6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYEGFSSH.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q987C6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDVSFHDLS SLDATQRSSL LKRAEADLSV FVEKVRPIIQ AVKDEGDAAL
60 70 80 90 100
IRFARELDKA NVAEGGLQVS EAEFDAAFDK VEKDVVESIG FGIDNIRRFH
110 120 130 140 150
EEQKPETMWL KEVRPGAYAG DRYTPIASVA LYVPRGKGAF PSVTMMTSVP
160 170 180 190 200
AVIAGVPQIA IVTPPTSDGS VDAATLVAAR LAGVHTVYKC GGAQAVAAVA
210 220 230 240 250
YGTETVKPAL KIVGPGSPWV VAAKSELSSI INTGLPAGPS EAIIFADDSV
260 270 280 290 300
DGGLAALDLL IEAEHGPDSS AYLVTHSRKV AEAALAALPQ HWSRMTEQRV
310 320 330 340 350
EFSRAVLTGK RGGIVLTASL EDSYRFINDY APEHLEILSK EPFAHLGHIT
360 370 380 390 400
EAAEILMGPH TPVTLANFVL GPNAVLPTSR WARTYGPLSV TDFVKRSSVG
410 420 430 440
YVTSAAYPEL AKHARRLARY EGFSSHENAV SEIRDRYLAG
Length:440
Mass (Da):47,089
Last modified:October 1, 2001 - v1
Checksum:i76FF8FD9E42CA90C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB53277.1.
RefSeqiNP_107491.1. NC_002678.2.
WP_010914584.1. NC_002678.2.

Genome annotation databases

EnsemblBacteriaiBAB53277; BAB53277; BAB53277.
GeneIDi1230146.
KEGGimlo:mlr7107.
PATRICi22485579. VBIMesLot2464_5669.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB53277.1 .
RefSeqi NP_107491.1. NC_002678.2.
WP_010914584.1. NC_002678.2.

3D structure databases

ProteinModelPortali Q987C6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266835.mlr7107.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB53277 ; BAB53277 ; BAB53277 .
GeneIDi 1230146.
KEGGi mlo:mlr7107.
PATRICi 22485579. VBIMesLot2464_5669.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YEGFSSH.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci MLOT266835:GJ9L-5642-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MAFF303099.

Entry informationi

Entry nameiHISX3_RHILO
AccessioniPrimary (citable) accession number: Q987C6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: October 1, 2001
Last modified: November 26, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

The conserved zinc-binding site Asp residue in position 367 is replaced by an Asn.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3