Reviewed, UniProtKB/Swiss-Prot Q987C6 (HISX3_RHILO)

Names and origin

Protein names

Recommended name:
    Histidinol dehydrogenase 3
      Short name=HDH 3
    EC=1.1.1.23

Gene names

Name:	hisD3
Ordered Locus Names:	mlr7107

Organism

Rhizobium loti (Mesorhizobium loti) [Complete proteome] [HAMAP]

Taxonomic identifier

381 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Mesorhizobium

Protein attributes

Sequence length	440 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.
Catalytic activity	L-histidinol + 2 NAD+ = L-histidine + 2 NADH. HAMAP MF_01024
Cofactor	Binds 1 zinc ion per subunit By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP MF_01024
Sequence similarities	Belongs to the histidinol dehydrogenase family.
Caution	The conserved zinc-binding site Asp residue in position 367 is replaced by an Asn.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro histidinol dehydrogenase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 440	440	Histidinol dehydrogenase 3 HAMAP MF_01024		PRO_0000135831
Sites
	Active site	333	1	Proton acceptor By similarity
	Active site	334	1	Proton acceptor By similarity
	Metal binding	262	1	Zinc By similarity
	Metal binding	265	1	Zinc By similarity
	Metal binding	426	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q987C6-1 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 76FF8FD9E42CA90C	FASTA	440	47,089
	10 20 30 40 50 60 MSDVSFHDLS SLDATQRSSL LKRAEADLSV FVEKVRPIIQ AVKDEGDAAL IRFARELDKA 70 80 90 100 110 120 NVAEGGLQVS EAEFDAAFDK VEKDVVESIG FGIDNIRRFH EEQKPETMWL KEVRPGAYAG 130 140 150 160 170 180 DRYTPIASVA LYVPRGKGAF PSVTMMTSVP AVIAGVPQIA IVTPPTSDGS VDAATLVAAR 190 200 210 220 230 240 LAGVHTVYKC GGAQAVAAVA YGTETVKPAL KIVGPGSPWV VAAKSELSSI INTGLPAGPS 250 260 270 280 290 300 EAIIFADDSV DGGLAALDLL IEAEHGPDSS AYLVTHSRKV AEAALAALPQ HWSRMTEQRV 310 320 330 340 350 360 EFSRAVLTGK RGGIVLTASL EDSYRFINDY APEHLEILSK EPFAHLGHIT EAAEILMGPH 370 380 390 400 410 420 TPVTLANFVL GPNAVLPTSR WARTYGPLSV TDFVKRSSVG YVTSAAYPEL AKHARRLARY 430 440 EGFSSHENAV SEIRDRYLAG

References

[1]

"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti." Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S. DNA Res. 7:331-338(2000) [PubMed: 11214968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MAFF303099.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000012 Genomic DNA. Translation: BAB53277.1.
RefSeq	NP_107491.1.
3D structure databases
HSSP	HSSP built from PDB template 1KAE based on UniProtKB P06988.
ModBase	Search...
Genome annotation databases
GeneID	1230146.
GenomeReviews	Gene locus mlr7107 in contig BA000012_GR.
KEGG	mlo:mlr7107.
NMPDR	fig|266835.1.peg.5592.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q987C6.
OMA	Q987C6. EAEHGPD.
Enzyme and pathway databases
BRENDA	1.1.1.23. 3315.
Family and domain databases
HAMAP	MF_01024. Divergent sequence. [Tree]
InterPro	IPR001692. Histidinol_DH_CS. IPR012131. Hstdl_DH_prok-type. [Graphical view]
PANTHER	PTHR21256:SF2. Hstdl_DH_prok. 1 hit.
Pfam	PF00815. Histidinol_dh. 1 hit. [Graphical view]
PRINTS	PR00083. HOLDHDRGNASE.
ProDom	PD002680. Histidinol_dh. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00069. hisD. 1 hit.
PROSITE	PS00611. HISOL_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HISX3_RHILO

Accession

Primary (citable) accession number: Q987C6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 25, 2003
Last sequence update:	October 1, 2001
Last modified:	June 16, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)