ID   Q98742_9GEMI            Unreviewed;       134 AA.
AC   Q98742;
DT   01-FEB-1997, integrated into UniProtKB/TrEMBL.
DT   01-FEB-1997, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   RecName: Full=Transcriptional activator protein {ECO:0000256|ARBA:ARBA00014388, ECO:0000256|RuleBase:RU363028};
DE            Short=TrAP {ECO:0000256|RuleBase:RU363028};
GN   Name=C2 {ECO:0000313|EMBL:AAB08931.1};
OS   Tomato leaf curl Karnataka virus.
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Repensiviricetes;
OC   Geplafuvirales; Geminiviridae; Begomovirus.
OX   NCBI_TaxID=220932 {ECO:0000313|EMBL:AAB08931.1};
RN   [1] {ECO:0000313|EMBL:AAB08931.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bangalore II {ECO:0000313|EMBL:AAB08931.1};
RA   Chatchawankanphanich O., Chiang B.-T., Green S.K., Singh S.J., Mehta P.,
RA   Maxwell D.P.;
RT   "Tomato leaf curl virus from Southern India: A monopartite whitefly-
RT   transmitted geminivirus.";
RL   Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AJW80925.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=TC120 {ECO:0000313|EMBL:AJW80925.1};
RA   Swarnalatha P., Venkatravanappa V., Jalali S., Krishna Reddy M.;
RT   "Molecular characterization of Tomato leaf curl Karnataka virus infecting
RT   tomato in India.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Strong activator of the late viral genes promoters. Acts as a
CC       suppressor of RNA-mediated gene silencing, also known as post-
CC       transcriptional gene silencing (PTGS), a mechanism of plant viral
CC       defense that limits the accumulation of viral RNAs. Also suppresses the
CC       host basal defense by interacting with and inhibiting SNF1 kinase, a
CC       key regulator of cell metabolism implicated in innate antiviral
CC       defense. Determines pathogenicity. {ECO:0000256|RuleBase:RU363028}.
CC   -!- SUBUNIT: Monomer. Homodimer. Homooligomer. Self-interaction correlates
CC       with nuclear localization and efficient activation of transcription.
CC       {ECO:0000256|RuleBase:RU363028}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC       cytoplasm {ECO:0000256|ARBA:ARBA00004192,
CC       ECO:0000256|RuleBase:RU363028}. Host nucleus
CC       {ECO:0000256|ARBA:ARBA00004147, ECO:0000256|RuleBase:RU363028}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- DOMAIN: The zinc finger and the transactivation region are involved in
CC       PTGS suppression. {ECO:0000256|RuleBase:RU363028}.
CC   -!- SIMILARITY: Belongs to the geminiviridae transcriptional activator
CC       protein family. {ECO:0000256|ARBA:ARBA00007672,
CC       ECO:0000256|RuleBase:RU363028}.
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DR   EMBL; U38239; AAB08931.1; -; Genomic_DNA.
DR   EMBL; KP178731; AJW80925.1; -; Genomic_DNA.
DR   RefSeq; NP_632011.1; NC_003897.1.
DR   GeneID; 944511; -.
DR   KEGG; vg:944511; -.
DR   OrthoDB; 11041at10239; -.
DR   Proteomes; UP000204375; Genome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR000942; Gemini_AL2.
DR   Pfam; PF01440; Gemini_AL2; 1.
DR   PRINTS; PR00230; GEMCOATAL2.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU363028};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU363028};
KW   Host cytoplasm {ECO:0000256|RuleBase:RU363028};
KW   Host nucleus {ECO:0000256|ARBA:ARBA00022562,
KW   ECO:0000256|RuleBase:RU363028};
KW   Host-virus interaction {ECO:0000256|RuleBase:RU363028};
KW   Inhibition of host innate immune response by virus
KW   {ECO:0000256|ARBA:ARBA00022463, ECO:0000256|RuleBase:RU363028};
KW   Metal-binding {ECO:0000256|RuleBase:RU363028};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Suppressor of RNA silencing {ECO:0000256|ARBA:ARBA00022463,
KW   ECO:0000256|RuleBase:RU363028};
KW   Viral immunoevasion {ECO:0000256|ARBA:ARBA00022463,
KW   ECO:0000256|RuleBase:RU363028}; Zinc {ECO:0000256|RuleBase:RU363028};
KW   Zinc-finger {ECO:0000256|RuleBase:RU363028}.
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          75..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        86..100
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        101..120
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   134 AA;  15174 MW;  7D46F3F0E6F36AD0 CRC64;
     MRPSSPPRAH STQVPIKVQH RLAKKGTRRR RVDLPCGCSY FIALACHDHG FTHRGTHHCS
     SSREWRVYLG DSKSPIFQDN RASQPAIPDE PRHHHRPSTV QSQPEESVGD TQMFPSLPNL
     DDLTASDWSF LKGI
//